Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 7 October 1988:
Vol. 242. no. 4875, pp. 74 - 77
DOI: 10.1126/science.2902687
Prev | Table of Contents | Next

Articles

Science, Vol 242, Issue 4875, 74-77
Copyright © 1988 by American Association for the Advancement of Science

articles

Pharmacological induction of use-dependent receptive field modifications in the visual cortex

JM Greuel, HJ Luhmann, and W Singer

Troponwerke, Department of Neurobiology, Koln, Federal Republic of Germany.

Lasting modifications of the receptive fields of neurons in the visual cortex can be induced by pairing visual stimuli with iontophoretic application of the neuromodulators acetylcholine and noradrenaline or the excitatory amino acids N-methyl-D-aspartate (NMDA) and L-glutamate. The modifications are obtained in less than 1 hour and persist for more than 40 minutes. Thus, acetylcholine and norepinephrine have a permissive role in use-dependent neuronal plasticity. These results support the notion of a postsynaptic threshold for neuronal malleability that differs from that of sodium-dependent action potentials.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Cholinergic Modulation of Spindle Bursts in the Neonatal Rat Visual Cortex In Vivo.
I. L. Hanganu, J. F. Staiger, Y. Ben-Ari, and R. Khazipov (2007)
J. Neurosci. 27, 5694-5705
   Abstract »    Full Text »    PDF »
Heterosynaptic Facilitation of In Vivo Thalamocortical Long-Term Potentiation in the Adult Rat Visual Cortex by Acetylcholine.
H. C. Dringenberg, B. Hamze, A. Wilson, W. Speechley, and M.-C. Kuo (2007)
Cereb Cortex 17, 839-848
   Abstract »    Full Text »    PDF »
Acetylcholine-Dependent Induction and Expression of Functional Plasticity in the Barrel Cortex of the Adult Rat.
V. Ego-Stengel, D. E. Shulz, S. Haidarliu, R. Sosnik, and E. Ahissar (2001)
J Neurophysiol 86, 422-437
   Abstract »    Full Text »    PDF »
Development and Plasticity of Cortical Processing Architectures.
W. Singer (1995)
Science 270, 758-764
   Abstract »    PDF »
Neuronal plasticity that underlies improvement in perceptual performance.
E Zohary, S Celebrini, K. Britten, and W. Newsome (1994)
Science 263, 1289-1292
   Abstract »    PDF »
Dependence of cortical plasticity on correlated activity of single neurons and on behavioral context.
E Ahissar, E Vaadia, M Ahissar, H Bergman, A Arieli, and M Abeles (1992)
Science 257, 1412-1415
   Abstract »    PDF »
Formation of Cortical Cell Assemblies.
W. Singer, C. Gray, A. Engel, P. Konig, A. Artola, and S. Brocher (1990)
Cold Spring Harb Symp Quant Biol 55, 939-952
   Abstract »    PDF »
Synaptic connections in vitro: modulation of number and efficacy by electrical activity.
P. Nelson, C Yu, R. Fields, and E. Neale (1989)
Science 244, 585-587
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)