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Science 16 September 1988:
Vol. 241. no. 4872, pp. 1501 - 1503
DOI: 10.1126/science.3138754
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Articles

Science, Vol 241, Issue 4872, 1501-1503
Copyright © 1988 by American Association for the Advancement of Science

articles

Antiproliferative activity of a hybrid protein between interferon-gamma and tumor necrosis factor-beta

GS Feng, PW Gray, HM Shepard, and MW Taylor

Department of Biology, Indiana University, Bloomington 47405.

A hybrid protein between interferon-gamma and tumor necrosis factor-beta was made by ligating the respective genes and expressing the fused genes under the control of the trp promoter in Escherichia coli. The antiproliferative activity of the hybrid protein in vitro was greatly increased compared with either interferon-gamma or tumor necrosis factor-beta alone, and both antiviral activity and cytotoxic effect were retained in the hybrid protein. The hybrid protein may have potential clinical application.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)