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Science 9 September 1988:
Vol. 241. no. 4871, pp. 1342 - 1345
DOI: 10.1126/science.3137660
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Articles

Science, Vol 241, Issue 4871, 1342-1345
Copyright © 1988 by American Association for the Advancement of Science

articles

Clonally related cortical cells show several migration patterns

C Walsh and CL Cepko

Department of Genetics, Harvard Medical School, Boston, MA 02115.

The mammalian cerebral cortex is organized into columns of cells with common functional properties. During embryogenesis, cortical neurons are formed deep, near the lateral ventricles, and migrate radially to their final position. This observation led to the suggestion that the cortex consists of radial, ontogenetic units of clonally related neurons. In the experiments reported here, this hypothesis was tested by studying cell lineage in the rat cortex with a retroviral vector carrying the Escherichia coli beta-galactosidase gene, which can be easily visualized. Labeled, clonally related cortical neurons did not occur in simple columnar arrays. Instead, clonally related neurons entered several different radial columns, apparently by migrating along different radial glial fibers.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)