Science 9 September 1988: Vol. 241. no. 4871, pp. 1331 - 1335 DOI: 10.1126/science.2842867

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Articles

Human Cdc34 Employs Distinct Sites To Coordinate Attachment of Ubiquitin to a Substrate and Assembly of Polyubiquitin Chains.

S. Gazdoiu, K. Yamoah, K. Wu, and Z.-Q. Pan (2007)
Mol. Cell. Biol. 27, 7041-7052
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitin proteasome pathway gene expression varies in rhesus monkey oocytes and embryos of different developmental potential.

N. R. Mtango and K. E. Latham (2007)
Physiol Genomics 31, 1-14
 |  Abstract »  |  Full Text »  |  PDF »

A Process Independent of the Anaphase-promoting Complex Contributes to Instability of the Yeast S Phase Cyclin Clb5.

F. Sari, G. H. Braus, and S. Irniger (2007)
J. Biol. Chem. 282, 26614-26622
 |  Abstract »  |  Full Text »  |  PDF »

SCF E3-Mediated Autoubiquitination Negatively Regulates Activity of Cdc34 E2 but Plays a Nonessential Role in the Catalytic Cycle In Vitro and In Vivo.

K. M. Scaglione, P. K. Bansal, A. E. Deffenbaugh, A. Kiss, J. M. Moore, S. Korolev, R. Cocklin, M. Goebl, K. Kitagawa, and D. Skowyra (2007)
Mol. Cell. Biol. 27, 5860-5870
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Analysis of Human Immunodeficiency Virus Type 1-Infected CD4+ Cell Proteome: Dysregulated Cell Cycle Progression and Nuclear Transport Coincide with Robust Virus Production.

E. Y. Chan, W.-J. Qian, D. L. Diamond, T. Liu, M. A. Gritsenko, M. E. Monroe, D. G. Camp II, R. D. Smith, and M. G. Katze (2007)
J. Virol. 81, 7571-7583
 |  Abstract »  |  Full Text »  |  PDF »

The early history of the ubiquitin field..

A. Varshavsky (2006)
Protein Sci. 15, 647-654
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Proteasome inhibitor therapy in multiple myeloma.

D. Chauhan, T. Hideshima, C. Mitsiades, P. Richardson, and K. C. Anderson (2005)
Mol. Cancer Ther. 4, 686-692
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of polarized growth initiation and termination cycles by the polarisome and Cdc42 regulators.

S. Bidlingmaier and M. Snyder (2004)
J. Cell Biol. 164, 207-218
 |  Abstract »  |  Full Text »  |  PDF »

Structural Control of Endoplasmic Reticulum-associated Degradation: EFFECT OF CHEMICAL CHAPERONES ON 3-HYDROXY-3-METHYLGLUTARYL-CoA REDUCTASE.

A. G. Shearer and R. Y. Hampton (2004)
J. Biol. Chem. 279, 188-196
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional regulation by histone ubiquitination and deubiquitination.

Y. Zhang (2003)
Genes & Dev. 17, 2733-2740
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Cdc34 Self-Association Is Facilitated by Ubiquitin Thiolester Formation and Is Required for Its Catalytic Activity.

X. Varelas, C. Ptak, and M. J. Ellison (2003)
Mol. Cell. Biol. 23, 5388-5400
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Multifunctional Binding Site on Ubc9p Required for Smt3p Conjugation.

K. P. Bencsath, M. S. Podgorski, V. R. Pagala, C. A. Slaughter, and B. A. Schulman (2002)
J. Biol. Chem. 277, 47938-47945
 |  Abstract »  |  Full Text »  |  PDF »

Rad6 Overexpression Induces Multinucleation, Centrosome Amplification, Abnormal Mitosis, Aneuploidy, and Transformation.

M. P. V. Shekhar, A. Lyakhovich, D. W. Visscher, H. Heng, and N. Kondrat (2002)
Cancer Res. 62, 2115-2124
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of the Ubiquitin-Conjugating Enzyme Cdc34 Confers Resistance to Methylmercury in Saccharomyces cerevisiae.

T. Furuchi, G.-W. Hwang, and A. Naganuma (2002)
Mol. Pharmacol. 61, 738-741
 |  Abstract »  |  Full Text »  |  PDF »

The Nedd8-conjugated ROC1-CUL1 Core Ubiquitin Ligase Utilizes Nedd8 Charged Surface Residues for Efficient Polyubiquitin Chain Assembly Catalyzed by Cdc34.

K. Wu, A. Chen, P. Tan, and Z.-Q. Pan (2002)
J. Biol. Chem. 277, 516-527
 |  Abstract »  |  Full Text »

Creation of a Pluripotent Ubiquitin-Conjugating Enzyme.

C. Ptak, C. Gwozd, J. T. Huzil, T. J. Gwozd, G. Garen, and M. J. Ellison (2001)
Mol. Cell. Biol. 21, 6537-6548
 |  Abstract »  |  Full Text »  |  PDF »

The Cbk1p Pathway Is Important for Polarized Cell Growth and Cell Separation in Saccharomyces cerevisiae.

S. Bidlingmaier, E. L. Weiss, C. Seidel, D. G. Drubin, and M. Snyder (2001)
Mol. Cell. Biol. 21, 2449-2462
 |  Abstract »  |  Full Text »

Functions of the DNA damage response pathway target Ho endonuclease of yeast for degradation via the ubiquitin-26S proteasome system.

L. Kaplun, Y. Ivantsiv, D. Kornitzer, and D. Raveh (2000)
PNAS 97, 10077-10082
 |  Abstract »  |  Full Text »  |  PDF »

Polarized Growth Controls Cell Shape and Bipolar Bud Site Selection in Saccharomyces cerevisiae.

Y.-J. Sheu, Y. Barral, and M. Snyder (2000)
Mol. Cell. Biol. 20, 5235-5247
 |  Abstract »  |  Full Text »

Isolation and Characterization of HRT1 Using a Genetic Screen for Mutants Unable to Degrade Gic2p in Saccharomyces cerevisiae.

M. Blondel, J.-M. Galan, and M. Peter (2000)
Genetics 155, 1033-1044
 |  Abstract »  |  Full Text »

Posttranslational Phosphorylation and Ubiquitination of the Saccharomyces cerevisiae Poly(A) Polymerase at the S/G2 Stage of the Cell Cycle.

N. Mizrahi and C. Moore (2000)
Mol. Cell. Biol. 20, 2794-2802
 |  Abstract »  |  Full Text »

Rad6-Dependent Ubiquitination of Histone H2B in Yeast.

K. Robzyk, J. Recht, and M. A. Osley (2000)
Science 287, 501-504
 |  Abstract »  |  Full Text »

Association of human ubiquitin-conjugating enzyme CDC34 with the mitotic spindle in anaphase.

F Reymond, C Wirbelauer, and W Krek (2000)
J. Cell Sci. 113, 1687-1694
 |  Abstract »  |  PDF »

Ubiquitin-dependent degradation of multiple F-box proteins by an autocatalytic mechanism.

J.-M. Galan and M. Peter (1999)
PNAS 96, 9124-9129
 |  Abstract »  |  Full Text »  |  PDF »

Human Cdc34 and Rad6B Ubiquitin-Conjugating Enzymes Target Repressors of Cyclic AMP-Induced Transcription for Proteolysis.

D. Pati, M. L. Meistrich, and S. E. Plon (1999)
Mol. Cell. Biol. 19, 5001-5013
 |  Abstract »  |  Full Text »  |  PDF »

An essential function of Grr1 for the degradation of Cln2 is to act as a binding core that links Cln2 to Skp1.

T Kishi and F Yamao (1999)
J. Cell Sci. 111, 3655-3661
 |  Abstract »  |  PDF »

Identification of the Ubiquitin Carrier Proteins, E2s, Involved in Signal-induced Conjugation and Subsequent Degradation of Ikappa Balpha.

H. Gonen, B. Bercovich, A. Orian, A. Carrano, C. Takizawa, K. Yamanaka, M. Pagano, K. Iwai, and A. Ciechanover (1999)
J. Biol. Chem. 274, 14823-14830
 |  Abstract »  |  Full Text »  |  PDF »

The Genetic Locus NRC-1 within Chromosome 3p12 Mediates Tumor Suppression in Renal Cell Carcinoma Independently of Histological Type, Tumor Microenvironment, and VHL Mutation.

M. Lovell, S. T. Lott, P. Wong, A. El-Naggar, S. Tucker, and A. M. Killary (1999)
Cancer Res. 59, 2182-2189
 |  Abstract »  |  Full Text »  |  PDF »

The Cdc6 Protein Is Ubiquitinated in Vivo for Proteolysis in Saccharomyces cerevisiae.

M. Sanchez, A. Calzada, and A. Bueno (1999)
J. Biol. Chem. 274, 9092-9097
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Determinants in E2 Ubiquitin-conjugating Enzymes Required for hect E3 Ubiquitin-Protein Ligase Interaction.

U. Nuber and M. Scheffner (1999)
J. Biol. Chem. 274, 7576-7582
 |  Abstract »  |  Full Text »  |  PDF »

The Abundance of Cell Cycle Regulatory Protein Cdc4p Is Controlled by Interactions between Its F Box and Skp1p.

N. Mathias, S. Johnson, B. Byers, and M. Goebl (1999)
Mol. Cell. Biol. 19, 1759-1767
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Ubiquitin Conjugation in Glucose-induced Proteolysis of Saccharomyces Maltose Permease.

I. Medintz, H. Jiang, and C. A. Michels (1998)
J. Biol. Chem. 273, 34454-34462
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Cdc28 Cyclin-Dependent Protein Kinase Activity during the Cell Cycle of the Yeast Saccharomyces cerevisiae.

M. D. Mendenhall and A. E. Hodge (1998)
Microbiol. Mol. Biol. Rev. 62, 1191-1243
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle- and Cln2p-Cdc28p-dependent Phosphorylation of the Yeast Ste20p Protein Kinase.

C. Wu, T. Leeuw, E. Leberer, D. Y. Thomas, and M. Whiteway (1998)
J. Biol. Chem. 273, 28107-28115
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Nuclear MyoD Is Required for Its Rapid Degradation.

A. Song, Q. Wang, M. G. Goebl, and M. A. Harrington (1998)
Mol. Cell. Biol. 18, 4994-4999
 |  Abstract »  |  Full Text »

Identification of Amino Acid Residues in a Class I Ubiquitin-conjugating Enzyme Involved in Determining Specificity of Conjugation of Ubiquitin to Proteins.

R. Oughtred, N. Bedard, A. Vrielink, and S. S. Wing (1998)
J. Biol. Chem. 273, 18435-18442
 |  Abstract »  |  Full Text »  |  PDF »

sud1+ targets cyclin-dependent kinase-phosphorylated Cdc18 and Rum1 proteins for degradation and stops unwanted diploidization in fission yeast.

P. V. Jallepalli, D. Tien, and T. J. Kelly (1998)
PNAS 95, 8159-8164
 |  Abstract »  |  Full Text »  |  PDF »

MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway.

S. Broomfield, B. L. Chow, and W. Xiao (1998)
PNAS 95, 5678-5683
 |  Abstract »  |  Full Text »  |  PDF »

Modification of yeast Cdc53p by the ubiquitin-related protein Rub1p affects function of the SCFCdc4 complex.

D. Lammer, N. Mathias, J. M. Laplaza, W. Jiang, Y. Liu, J. Callis, M. Goebl, and M. Estelle (1998)
Genes & Dev. 12, 914-926
 |  Abstract »  |  Full Text »

Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast.

E. E. Patton, A. R. Willems, D. Sa, L. Kuras, D. Thomas, K. L. Craig, and M. Tyers (1998)
Genes & Dev. 12, 692-705
 |  Abstract »  |  Full Text »

An Essential Domain within Cdc34p Is Required for Binding to a Complex Containing Cdc4p and Cdc53p in Saccharomyces cerevisiae.

N. Mathias, C. N. Steussy, and M. G. Goebl (1998)
J. Biol. Chem. 273, 4040-4045
 |  Abstract »  |  Full Text »  |  PDF »

The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal.

A. Pause, S. Lee, K. M. Lonergan, and R. D. Klausner (1998)
PNAS 95, 993-998
 |  Abstract »  |  Full Text »  |  PDF »

NF-kappa B p105 Processing via the Ubiquitin-Proteasome Pathway.

C. Sears, J. Olesen, D. Rubin, D. Finley, and T. Maniatis (1998)
J. Biol. Chem. 273, 1409-1419
 |  Abstract »  |  Full Text »  |  PDF »

slimb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development.

N. Theodosiou, S Zhang, W. Wang, and T Xu (1998)
Development 125, 3411-3416
 |  Abstract »  |  PDF »

The Cdk inhibitors p25rum1 and p40SIC1 are functional homologues that play similar roles in the regulation of the cell cycle in fission and budding yeast.

A Sanchez-Diaz, I Gonzalez, M Arellano, and S Moreno (1998)
J. Cell Sci. 111, 843-851
 |  Abstract »  |  PDF »

Cln3-Associated Kinase Activity in Saccharomyces cerevisiae Is Regulated by the Mating Factor Pathway.

D.-I. Jeoung, L. J. W. M. Oehlen, and F. R. Cross (1998)
Mol. Cell. Biol. 18, 433-441
 |  Abstract »  |  Full Text »

sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.

E. J. A. Hubbard, G. Wu, J. Kitajewski, and I. Greenwald (1997)
Genes & Dev. 11, 3182-3193
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast.

S. Henchoz, Y. Chi, B. Catarin, I. Herskowitz, R. J. Deshaies, and M. Peter (1997)
Genes & Dev. 11, 3046-3060
 |  Abstract »  |  Full Text »  |  PDF »

Activity of Ubiquitin-dependent Pathway in Response to Oxidative Stress. UBIQUITIN-ACTIVATING ENZYME IS TRANSIENTLY UP-REGULATED.

F. Shang, X. Gong, and A. Taylor (1997)
J. Biol. Chem. 272, 23086-23093
 |  Abstract »  |  Full Text »  |  PDF »

Fission yeast WD-repeat protein pop1 regulates genome ploidy through ubiquitin-proteasome-mediated degradation of the CDK inhibitor Rum1 and the S-phase initiator Cdc18..

K Kominami and T Toda (1997)
Genes & Dev. 11, 1548-1560
 |  Abstract »  |  PDF »

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins.

A. Pause, S. Lee, R. A. Worrell, D. Y. T. Chen, W. H. Burgess, W. M. Linehan, and R. D. Klausner (1997)
PNAS 94, 2156-2161
 |  Abstract »  |  Full Text »  |  PDF »

The Yeast CDC37 Gene Interacts with MPS1 and Is Required for Proper Execution of Spindle Pole Body Duplication.

A. R. Schutz, T. H. Giddings Jr., E. Steiner, and M. Winey (1997)
J. Cell Biol. 136, 969-982
 |  Abstract »  |  Full Text »  |  PDF »

The SAR1 gene of Arabidopsis acts downstream of the AXR1 gene in auxin response.

A Cernac, C Lincoln, D Lammer, and M Estelle (1997)
Development 124, 1583-1591
 |  Abstract »  |  PDF »

Cdc6p establishes and maintains a state of replication competence during G1 phase.

C. Detweiler and J. Li (1997)
J. Cell Sci. 110, 753-763
 |  Abstract »  |  PDF »

A Yeast Ubc9 Mutant Protein with Temperature-sensitive in Vivo Function Is Subject to Conditional Proteolysis by a Ubiquitin- and Proteasome-dependent Pathway.

J. Betting and W. Seufert (1996)
J. Biol. Chem. 271, 25790-25796
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitin-activating Enzyme E1 Is Phosphorylated and Localized to the Nucleus in a Cell Cycle-dependent Manner.

A. G. Stephen, J. S. Trausch-Azar, A. Ciechanover, and A. L. Schwartz (1996)
J. Biol. Chem. 271, 15608-15614
 |  Abstract »  |  Full Text »  |  PDF »

The Arabidopsis thaliana UBC7/13/14 Genes Encode a Family of Multiubiquitin Chain-forming E2 Enzymes.

S. van Nocker, J. M. Walker, and R. D. Vierstra (1996)
J. Biol. Chem. 271, 12150-12158
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Family of Ubiquitin-conjugating Enzymes with Distinct Amino-terminal Extensions.

K. Matuschewski, H.-P. Hauser, M. Treier, and S. Jentsch (1996)
J. Biol. Chem. 271, 2789-2794
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Novel Keratinocyte Ubiquitin Carrier Protein.

Z. Liu, A. L. Haas, L. A. Diaz, C. A. Conrad, and G. J. Giudice (1996)
J. Biol. Chem. 271, 2817-2822
 |  Abstract »  |  Full Text »  |  PDF »

Coordination of cellular events that precede reproductive onset in Acetabularia acetabulum: evidence for a 'loop' in development.

L. Runft and D. Mandoli (1996)
Development 122, 1187-1194
 |  Abstract »  |  PDF »

Characterization of a Dominant Negative Mutant of the Cell Cycle Ubiquitin-conjugating Enzyme Cdc34.

A. Banerjee, R. J. Deshaies, and V. Chau (1995)
J. Biol. Chem. 270, 26209-26215
 |  Abstract »  |  Full Text »  |  PDF »

Catabolite Inactivation of Fructose-1,6-bisphosphatase of Saccharomyces cerevisiae.

S. M. Schork, M. Thumm, and D. H. Wolf (1995)
J. Biol. Chem. 270, 26446-26450
 |  Abstract »  |  Full Text »  |  PDF »

Increased Ubiquitin Expression Suppresses the Cell Cycle Defect Associated with the Yeast Ubiquitin Conjugating Enzyme, CDC34 (UBC3).

J. A. Prendergast, C. Ptak, T. G. Arnason, and M. J. Ellison (1995)
J. Biol. Chem. 270, 9347-9352
 |  Abstract »  |  Full Text »  |  PDF »

Developmental Changes of the 26 S Proteasome in Abdominal Intersegmental Muscles of Manduca sexta during Programmed Cell Death.

S. P. Dawson, J. E. Arnold, N. J. Mayer, S. E. Reynolds, M. A. Billett, C. Gordon, L. Colleaux, P. M. Kloetzel, K. Tanaka, and R. J. Mayer (1995)
J. Biol. Chem. 270, 1850-1858
 |  Abstract »  |  Full Text »  |  PDF »

Ubiquitin-activating enzyme, E1, is phosphorylated in mammalian cells by the protein kinase Cdc2.

Y Nagai, S Kaneda, K Nomura, H Yasuda, T Seno, and F Yamao (1995)
J. Cell Sci. 108, 2145-2152
 |  Abstract »  |  PDF »

The levels of ubiquitinated histone H2A are highly upregulated in transformed human cells: partial colocalization of uH2A clusters and PCNA/cyclin foci in a fraction of cells in S-phase.

A. Vassilev, H. Rasmussen, E. Christensen, S Nielsen, and J. Celis (1995)
J. Cell Sci. 108, 1205-1215
 |  Abstract »  |  PDF »

P40SDB25, a putative CDK inhibitor, has a role in the M/G1 transition in Saccharomyces cerevisiae..

J D Donovan, J H Toyn, A L Johnson, and L H Johnston (1994)
Genes & Dev. 8, 1640-1653
 |  Abstract »  |  PDF »

Negative regulation of FAR1 at the Start of the yeast cell cycle..

J D McKinney, F Chang, N Heintz, and F R Cross (1993)
Genes & Dev. 7, 833-843
 |  Abstract »  |  PDF »

The extremely conserved amino terminus of RAD6 ubiquitin-conjugating enzyme is essential for amino-end rule-dependent protein degradation..

J F Watkins, P Sung, S Prakash, and L Prakash (1993)
Genes & Dev. 7, 250-261
 |  Abstract »  |  PDF »

Heat shock results in cell cycle delay and synchronisation of mitotic domains in cellularised Drosophila melanogaster embryos.

G Maldonado-Codina, S Llamazares, and D. Glover (1993)
J. Cell Sci. 105, 711-720
 |  Abstract »  |  PDF »

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein.

V Chau, J. Tobias, A Bachmair, D Marriott, D. Ecker, D. Gonda, and A Varshavsky (1989)
Science 243, 1576-1583
 |  Abstract »  |  PDF »

The RAD6 protein of Saccharomyces cerevisiae polyubiquitinates histones, and its acidic domain mediates this activity..

P Sung, S Prakash, and L Prakash (1988)
Genes & Dev. 2, 1476-1485
 |  Abstract »  |  PDF »

Regulation of Nuclear Transport and Degradation of the Xenopus Cyclin-dependent Kinase Inhibitor, p27Xic1.

L.-C. Chuang and P. R. Yew (2001)
J. Biol. Chem. 276, 1610-1617
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of the Human Ubiquitin-conjugating Enzyme, CDC34, by Casein Kinase 2.

K. Block, T. G. Boyer, and P. R. Yew (2001)
J. Biol. Chem. 276, 41049-41058
 |  Abstract »  |  Full Text »  |  PDF »

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