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Science 2 September 1988:
Vol. 241. no. 4870, pp. 1228 - 1229
DOI: 10.1126/science.2970671
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Articles
Science, Vol 241, Issue 4870, 1228-1229
Copyright © 1988 by American Association for the Advancement of Science
The human laminin receptor is a member of the integrin family of cell adhesion receptors
KR Gehlsen,
L Dillner,
E Engvall,
and
E Ruoslahti
Cancer Research Center, La Jolla Cancer Research Foundation, CA 92037.
A receptor for the adhesive basement membrane protein, laminin, was isolated from human glioblastoma cells by affinity chromatography on laminin. This receptor has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as fibronectin and vitronectin. Incorporation of the laminin receptor into liposomal membranes makes it possible for liposomes to attach to surfaces coated with laminin. The receptor liposomes also attached to some extent to surfaces coated with fibronectin, but not with other matrix proteins. These properties identify the laminin receptor as a member of the integrin family of cell adhesion receptors.
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