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Science 19 August 1988:
Vol. 241. no. 4868, pp. 968 - 970
DOI: 10.1126/science.2457254
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Articles

Science, Vol 241, Issue 4868, 968-970
Copyright © 1988 by American Association for the Advancement of Science

articles

Antiphosphotyrosine recovery of phospholipase C activity after EGF treatment of A-431 cells

MI Wahl, TO Daniel, and G Carpenter

Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232.

A tenfold increase in phospholipase C activity specific for phosphatidylinositol 4,5-bisphosphate (PIP2) was immunopurified from extracts of A-431 epidermoid carcinoma cells stimulated with epidermal growth factor. This finding suggests a biochemical link between growth factor-stimulated tyrosine kinase activity and PIP2 hydrolysis.


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