Science 12 August 1988: Vol. 241. no. 4867, pp. 825 - 828 DOI: 10.1126/science.3136546

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Characterization of the Interleukin (IL)-6 Inhibitor IL-6-RFP: FUSED RECEPTOR DOMAINS ACT AS HIGH AFFINITY CYTOKINE-BINDING PROTEINS.

S. Metz, M. Wiesinger, M. Vogt, H. Lauks, G. Schmalzing, P. C. Heinrich, and G. Muller-Newen (2007)
J. Biol. Chem. 282, 1238-1248
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 in aging and chronic disease: a magnificent pathway..

M. Maggio, J. M. Guralnik, D. L. Longo, and L. Ferrucci (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 575-584
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Dynamics of the gp130 cytokine complex: A model for assembly on the cellular membrane.

A. Schroers, O. Hecht, K.-J. Kallen, M. Pachta, S. Rose-John, and J. Grotzinger (2005)
Protein Sci. 14, 783-790
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Variation in the Interleukin-6 Receptor Gene Associates With Type 2 Diabetes in Danish Whites.

Y. H. Hamid, S. A. Urhammer, D. P. Jensen, C. Glumer, K. Borch-Johnsen, T. Jorgensen, T. Hansen, and O. Pedersen (2004)
Diabetes 53, 3342-3345
 |  Abstract »  |  Full Text »  |  PDF »

Two Different Contact Sites Are Recruited by Cardiotrophin-like Cytokine (CLC) to Generate the CLC/CLF and CLC/sCNTFR{alpha} Composite Cytokines.

D. Perret, C. Guillet, G. Elson, J. Froger, H. Plun-Favreau, F. Rousseau, M. Chabbert, J.-F. Gauchat, and H. Gascan (2004)
J. Biol. Chem. 279, 43961-43970
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Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow.

A. Bernardo, C. Ball, L. Nolasco, J. F. Moake, and J.-f. Dong (2004)
Blood 104, 100-106
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Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs.

S. W. Lindemann, C. C. Yost, M. M. Denis, T. M. McIntyre, A. S. Weyrich, and G. A. Zimmerman (2004)
PNAS 101, 7076-7081
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Functional Characterization of W147A: A High-Affinity Interleukin-11 Antagonist.

N. Underhill-Day, L. A. McGovern, N. Karpovich, H. J. Mardon, V. A. Barton, and J. K. Heath (2003)
Endocrinology 144, 3406-3414
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Leukemia Inhibitory Factor (LIF), Cardiotrophin-1, and Oncostatin M Share Structural Binding Determinants in the Immunoglobulin-like Domain of LIF Receptor.

H. Plun-Favreau, D. Perret, C. Diveu, J. Froger, S. Chevalier, E. Lelievre, H. Gascan, and M. Chabbert (2003)
J. Biol. Chem. 278, 27169-27179
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MIF Signal Transduction Initiated by Binding to CD74.

L. Leng, C. N. Metz, Y. Fang, J. Xu, S. Donnelly, J. Baugh, T. Delohery, Y. Chen, R. A. Mitchell, and R. Bucala (2003)
J. Exp. Med. 197, 1467-1476
 |  Abstract »  |  Full Text »  |  PDF »

A Fusion Protein of the gp130 and Interleukin-6Ralpha Ligand-binding Domains Acts as a Potent Interleukin-6 Inhibitor.

C. Ancey, A. Kuster, S. Haan, A. Herrmann, P. C. Heinrich, and G. Muller-Newen (2003)
J. Biol. Chem. 278, 16968-16972
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Activation of Nuclear Factor {kappa}B p50/p65 and Fra-1 and JunD Is Essential for Deregulated Interleukin 6 Expression in Prostate Cancer.

L. F. Zerbini, Y. Wang, J.-Y. Cho, and T. A Libermann (2003)
Cancer Res. 63, 2206-2215
 |  Abstract »  |  Full Text »  |  PDF »

SHP2 and SOCS3 Contribute to Tyr-759-dependent Attenuation of Interleukin-6 Signaling through gp130.

U. Lehmann, J. Schmitz, M. Weissenbach, R. M. Sobota, M. Hortner, K. Friederichs, I. Behrmann, W. Tsiaris, A. Sasaki, J. Schneider-Mergener, et al. (2003)
J. Biol. Chem. 278, 661-671
 |  Abstract »  |  Full Text »  |  PDF »

Protective Effects of IL-6 Blockade in Sepsis Are Linked to Reduced C5a Receptor Expression.

N. C. Riedemann, T. A. Neff, R.-F. Guo, K. D. Bernacki, I. J. Laudes, J. V. Sarma, J. D. Lambris, and P. A. Ward (2003)
J. Immunol. 170, 503-507
 |  Abstract »  |  Full Text »  |  PDF »

Structure of the extracellular domains of the human interleukin-6 receptor alpha -chain.

J. N. Varghese, R. L. Moritz, M.-Z. Lou, A. van Donkelaar, H. Ji, N. Ivancic, K. M. Branson, N. E. Hall, and R. J. Simpson (2002)
PNAS 99, 15959-15964
 |  Abstract »  |  Full Text »  |  PDF »

A molecular compendium of genes expressed in multiple myeloma.

J. O. Claudio, E. Masih-Khan, H. Tang, J. Goncalves, M. Voralia, Z. H. Li, V. Nadeem, E. Cukerman, O. Francisco-Pabalan, C. C. Liew, et al. (2002)
Blood 100, 2175-2186
 |  Abstract »  |  Full Text »  |  PDF »

Erythropoietin in Human Milk: Physiology and Role in Infant Health.

R. D. Semba and S. E. Juul (2002)
J Hum Lact 18, 252-261
 |  Abstract »  |  PDF »

Reproductive Hormone-Induced, STAT3-Mediated Interleukin 6 Action in Normal and Malignant Human Ovarian Surface Epithelial Cells.

V. Syed, G. Ulinski, S. C. Mok, and S.-M. Ho (2002)
J Natl Cancer Inst 94, 617-629
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Androgen Receptor N-terminal Domain by Interleukin-6 via MAPK and STAT3 Signal Transduction Pathways.

T. Ueda, N. Bruchovsky, and M. D. Sadar (2002)
J. Biol. Chem. 277, 7076-7085
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Autocrine Production of Interleukin 6 Causes Multidrug Resistance in Breast Cancer Cells.

D. Conze, L. Weiss, P. S. Regen, A. Bhushan, D. Weaver, P. Johnson, and M. Rincon (2001)
Cancer Res. 61, 8851-8858
 |  Abstract »  |  Full Text »  |  PDF »

The soluble interleukin 6 receptor: mechanisms of production and implications in disease.

S. A. JONES, S. HORIUCHI, N. TOPLEY, N. YAMAMOTO, and G. M. FULLER (2001)
FASEB J 15, 43-58
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Heparin-Binding Properties of IL-6.

R. S. Mummery and C. C. Rider (2000)
J. Immunol. 165, 5671-5679
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Constitutive Stat3, Tyr705, and Ser727 phosphorylation in acute myeloid leukemia cells caused by the autocrine secretion of interleukin-6.

J.-J. Schuringa, A. T. J. Wierenga, W. Kruijer, and E. Vellenga (2000)
Blood 95, 3765-3770
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a gp130 Cytokine Receptor Critical Site Involved in Oncostatin M Response.

C. Olivier, P. Auguste, M. Chabbert, E. Lelievre, S. Chevalier, and H. Gascan (2000)
J. Biol. Chem. 275, 5648-5656
 |  Abstract »  |  Full Text »  |  PDF »

Studies on the Interleukin-6-type Cytokine Signal Transducer gp130 Reveal a Novel Mechanism of Receptor Activation by Monoclonal Antibodies.

G. Muller-Newen, A. Kuster, J. Wijdenes, F. Schaper, and P. C. Heinrich (2000)
J. Biol. Chem. 275, 4579-4586
 |  Abstract »  |  Full Text »  |  PDF »

The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized madin-darby canine kidney cells.

A. Martens, J. Bode, P. Heinrich, and L Graeve (2000)
J. Cell Sci. 113, 3593-3602
 |  Abstract »  |  PDF »

Effects of interleukin-6 (IL-6) on cytotrophoblastic cells.

A. Meisser, P. Cameo, D. Islami, A. Campana, and P. Bischof (1999)
Mol. Hum. Reprod. 5, 1055-1058
 |  Abstract »  |  Full Text »  |  PDF »

Novel Path to Activation of Vascular Smooth Muscle Cells: Up-Regulation of gp130 Creates an Autocrine Activation Loop by IL-6 and Its Soluble Receptor.

M. Klouche, S. Bhakdi, M. Hemmes, and S. Rose-John (1999)
J. Immunol. 163, 4583-4589
 |  Abstract »  |  Full Text »  |  PDF »

Novel neurotrophin-1/B cell-stimulating factor-3: A cytokine of the IL-6 family.

G. Senaldi, B. C. Varnum, U. Sarmiento, C. Starnes, J. Lile, S. Scully, J. Guo, G. Elliott, J. McNinch, C. L. Shaklee, et al. (1999)
PNAS 96, 11458-11463
 |  Abstract »  |  Full Text »  |  PDF »

Growth Inhibition of a Human Myeloma Cell Line by All-trans Retinoic Acid Is Not Mediated Through Downregulation of Interleukin-6 Receptors but Through Upregulation of p21WAF1.

Y.-H. Chen, D. Lavelle, J. DeSimone, S. Uddin, L. C. Platanias, and M. Hankewych (1999)
Blood 94, 251-259
 |  Abstract »  |  Full Text »  |  PDF »

The STAT3-independent Signaling Pathway by Glycoprotein 130 in Hepatic Cells.

C.-f. Lai, J. Ripperger, Y. Wang, H. Kim, R. B. Hawley, and H. Baumann (1999)
J. Biol. Chem. 274, 7793-7802
 |  Abstract »  |  Full Text »  |  PDF »

Disulfide Bond Structure and N-Glycosylation Sites of the Extracellular Domain of the Human Interleukin-6 Receptor.

A. R. Cole, N. E. Hall, H. R. Treutlein, J. S. Eddes, G. E. Reid, R. L. Moritz, and R. J. Simpson (1999)
J. Biol. Chem. 274, 7207-7215
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Three Distinct Receptor Binding Sites of Murine Interleukin-11.

V. A. Barton, K. R. Hudson, and J. K. Heath (1999)
J. Biol. Chem. 274, 5755-5761
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Signal Transducer Glycoprotein 130 by Both IL-6 and IL-11 Requires Two Distinct Binding Epitopes.

I. Kurth, U. Horsten, S. Pflanz, H. Dahmen, A. Kuster, J. Grotzinger, P. C. Heinrich, and G. Muller-Newen (1999)
J. Immunol. 162, 1480-1487
 |  Abstract »  |  Full Text »  |  PDF »

Fyn Associates with Cbl and Phosphorylates Tyrosine 731 in Cbl, A Binding Site for Phosphatidylinositol 3-Kinase.

S. Hunter, E. A. Burton, S. C. Wu, and S. M. Anderson (1999)
J. Biol. Chem. 274, 2097-2106
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 and Soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis.

M. Peters, A. M. Muller, and S. Rose-John (1998)
Blood 92, 3495-3504
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T-Lymphocyte Interleukin 6 Receptor Binding in Patients With Dementia of Alzheimer Type.

P. Bongioanni, B. Boccardi, M. Borgna, and B. Rossi (1998)
Arch Neurol 55, 1305-1308
 |  Abstract »  |  Full Text »  |  PDF »

Upregulation of Interleukin 6 and Granulocyte Colony-Stimulating Factor Receptors by Transcription Factor CCAAT Enhancer Binding Protein alpha  (C/EBPalpha ) Is Critical for Granulopoiesis.

P. Zhang, A. Iwama, M. W. Datta, G. J. Darlington, D. C. Link, and D. G. Tenen (1998)
J. Exp. Med. 188, 1173-1184
 |  Abstract »  |  Full Text »  |  PDF »

The Membrane Proximal Cytokine Receptor Domain of the Human Interleukin-6 Receptor Is Sufficient for Ligand Binding but Not for gp130 Association.

S. Ozbek, J. Grotzinger, B. Krebs, M. Fischer, A. Wollmer, T. Jostock, J. Mullberg, and S. Rose-John (1998)
J. Biol. Chem. 273, 21374-21379
 |  Abstract »  |  Full Text »  |  PDF »

A New Cytokine-Dependent Monoblastic Cell Line With t(9;11)(p22;q23) Differentiates to Macrophages With Macrophage Colony-Stimulating Factor (M-CSF) and to Osteoclast-Like Cells With M-CSF and Interleukin-4.

T. Ikeda, K. Sasaki, K. Ikeda, G. Yamaoka, K. Kawanishi, Y. Kawachi, T. Uchida, J. Takahara, and S. Irino (1998)
Blood 91, 4543-4553
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Modeling-guided Mutagenesis of the Extracellular Part of gp130 Leads to the Identification of Contact Sites in the Interleukin-6 (IL-6)·IL-6 receptor·gp130 Complex.

U. Horsten, G. Muller-Newen, C. Gerhartz, A. Wollmer, J. Wijdenes, P. C. Heinrich, and J. Grotzinger (1997)
J. Biol. Chem. 272, 23748-23757
 |  Abstract »  |  Full Text »  |  PDF »

Signaling of the Cardiotrophin-1 Receptor. EVIDENCE FOR A THIRD RECEPTOR COMPONENT.

O. Robledo, M. Fourcin, S. Chevalier, C. Guillet, P. Auguste, A. Pouplard-Barthelaix, D. Pennica, and H. Gascan (1997)
J. Biol. Chem. 272, 4855-4863
 |  Abstract »  |  Full Text »  |  PDF »

Extramedullary Expansion of Hematopoietic Progenitor Cells in Interleukin (IL)-6-sIL-6R Double Transgenic Mice.

M. Peters, P. Schirmacher, J. Goldschmitt, M. Odenthal, C. Peschel, E. Fattori, G. Ciliberto, H.-P. Dienes, K.-H. M. z. Buschenfelde, and S. Rose-John (1997)
J. Exp. Med. 185, 755-766
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin (IL)-6 Directs the Differentiation of IL-4-producing CD4+ T Cells.

M. Rincon, J. Anguita, T. Nakamura, E. Fikrig, and R. A. Flavell (1997)
J. Exp. Med. 185, 461-470
 |  Abstract »  |  Full Text »  |  PDF »

Functional Expression of Soluble Human Interleukin-11 (IL-11) Receptor alpha and Stoichiometry of in Vitro IL-11 Receptor Complexes with gp130.

P. Neddermann, R. Graziani, G. Ciliberto, and G. Paonessa (1996)
J. Biol. Chem. 271, 30986-30991
 |  Abstract »  |  Full Text »  |  PDF »

A Single Tyrosine Residue in the Membrane-proximal Domain of the Granulocyte-Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 Receptor Common beta -Chain Is Necessary and Sufficient for High Affinity Binding and Signaling by All Three Ligands.

J. M. Woodcock, C. J. Bagley, B. Zacharakis, and A. F. Lopez (1996)
J. Biol. Chem. 271, 25999-26006
 |  Abstract »  |  Full Text »  |  PDF »

Alanine Substitution for Thr268 and Asp269 of Soluble Ciliary Neurotrophic Factor (CNTF) Receptor alpha Component Defines a Specific Antagonist for the CNTF Response.

P. Auguste, O. Robledo, C. Olivier, J. Froger, V. Praloran, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 26049-26056
 |  Abstract »  |  Full Text »  |  PDF »

Influence of Interleukin-6 (IL-6) Dimerization on Formation of the High Affinity Hexameric IL-6·Receptor Complex.

L. D. Ward, A. Hammacher, G. J. Howlett, J. M. Matthews, L. Fabri, R. L. Moritz, E. C. Nice, J. Weinstock, and R. J. Simpson (1996)
J. Biol. Chem. 271, 20138-20144
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130. I. DEFINITION OF A NOVEL PHOSPHOTYROSINE MOTIF MEDIATING STAT1 ACTIVATION.

C. Gerhartz, B. Heesel, J. Sasse, U. Hemmann, C. Landgraf, J. Schneider-Mergener, F. Horn, P. C. Heinrich, and L. Graeve (1996)
J. Biol. Chem. 271, 12991-12998
 |  Abstract »  |  Full Text »  |  PDF »

Differential Activation of Acute Phase Response Factor/Stat3 and Stat1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130. II. Src HOMOLOGY SH2 DOMAINS DEFINE THE SPECIFICITY OF STAT FACTOR ACTIVATION.

U. Hemmann, C. Gerhartz, B. Heesel, J. Sasse, G. Kurapkat, J. Grotzinger, A. Wollmer, Z. Zhong, J. E. Darnell Jr., L. Graeve, et al. (1996)
J. Biol. Chem. 271, 12999-13007
 |  Abstract »  |  Full Text »  |  PDF »

gp130 Transducing Receptor Cross-linking Is Sufficient to Induce Interleukin-6 Type Responses.

M. Fourcin, S. Chevalier, C. Guillet, O. Robledo, J. Froger, A. Pouplard-Barthelaix, and H. Gascan (1996)
J. Biol. Chem. 271, 11756-11760
 |  Abstract »  |  Full Text »  |  PDF »

Cardiotrophin-1 Activates a Distinct Form of Cardiac Muscle Cell Hypertrophy.

K. C. Wollert, T. Taga, M. Saito, M. Narazaki, T. Kishimoto, C. C. Glembotski, A. B. Vernallis, J. K. Heath, D. Pennica, W. I. Wood, et al. (1996)
J. Biol. Chem. 271, 9535-9545
 |  Abstract »  |  Full Text »  |  PDF »

The Interleukin-6 (IL-6) Partial Antagonist (Q159E,T162P)IL-6 Interacts with the IL-6 Receptor and gp130 but Fails to Induce a Stable Hexameric Receptor Complex.

A. Hammacher, R. J. Simpson, and E. C. Nice (1996)
J. Biol. Chem. 271, 5464-5473
 |  Abstract »  |  Full Text »  |  PDF »

Designer Cytokines: Targeting Actions to Cells of Choice.

A. N. Economides, J. V. Ravetch, G. D. Yancopoulos, and N. Stahl (1995)
Science 270, 1351-1353
 |  Abstract »  |  PDF »

Requirement for the Immunoglobulin-like Domain of Granulocyte Colony-stimulating Factor Receptor in Formation of a 2:1 Receptor-Ligand Complex.

O. Hiraoka, H. Anaguchi, A. Asakura, and Y. Ota (1995)
J. Biol. Chem. 270, 25928-25934
 |  Abstract »  |  Full Text »  |  PDF »

Separate Signaling Mechanisms Are Involved in the Control of STAT Protein Activation and Gene Regulation via the Interleukin 6 Response Element by the Box 3 Motif of gp130.

C.-F. Lai, J. Ripperger, K. K. Morella, Y. Wang, D. P. Gearing, G. H. Fey, and H. Baumann (1995)
J. Biol. Chem. 270, 14847-14850
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-6 (IL-6) Antagonism by Soluble IL-6 Receptor [IMAGE] Mutated in the Predicted gp130-binding Interface.

A. L. Salvati, A. Lahm, G. Paonessa, G. Ciliberto, and C. Toniatti (1995)
J. Biol. Chem. 270, 12242-12249
 |  Abstract »  |  Full Text »  |  PDF »

Structure-Function Relationships in Human Interleukin-11.

M. J. Czupryn, J. M. McCoy, and H. A. Scoble (1995)
J. Biol. Chem. 270, 978-985
 |  Abstract »  |  Full Text »  |  PDF »

Functional isolation and characterization of human hematopoietic stem cells.

A. Berardi, A Wang, J. Levine, P Lopez, and D. Scadden (1995)
Science 267, 104-108
 |  Abstract »  |  PDF »

LIFR beta and gp130 as heterodimerizing signal transducers of the tripartite CNTF receptor.

S Davis, T. Aldrich, N Stahl, L Pan, T Taga, T Kishimoto, N. Ip, and G. Yancopoulos (1993)
Science 260, 1805-1808
 |  Abstract »  |  PDF »

Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses.

S Davis, T. Aldrich, N. Ip, N Stahl, S Scherer, T Farruggella, P. DiStefano, R Curtis, N Panayotatos, H Gascan, et al. (1993)
Science 259, 1736-1739
 |  Abstract »  |  PDF »

Interleukin-6 and its receptor: a paradigm for cytokines.

T Kishimoto, S Akira, and T Taga (1992)
Science 258, 593-597
 |  Abstract »  |  PDF »

Cloning of the gamma chain of the human IL-2 receptor.

T Takeshita, H Asao, K Ohtani, N Ishii, S Kumaki, N Tanaka, H Munakata, M Nakamura, and K Sugamura (1992)
Science 257, 379-382
 |  Abstract »  |  PDF »

The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor.

D. Gearing, M. Comeau, D. Friend, S. Gimpel, C. Thut, J McGourty, K. Brasher, J. King, S Gillis, B Mosley, et al. (1992)
Science 255, 1434-1437
 |  Abstract »  |  PDF »

The receptor for ciliary neurotrophic factor.

S Davis, T. Aldrich, D. Valenzuela, V. Wong, M. Furth, S. Squinto, and G. Yancopoulos (1991)
Science 253, 59-63
 |  Abstract »  |  PDF »

Glycosylphosphatidylinositol: a candidate system for interleukin-2 signal transduction.

D. Eardley and M. Koshland (1991)
Science 251, 78-81
 |  Abstract »  |  PDF »

A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins.

C. Smith, T Davis, D Anderson, L Solam, M. Beckmann, R Jerzy, S. Dower, D Cosman, and R. Goodwin (1990)
Science 248, 1019-1023
 |  Abstract »  |  PDF »

Cloning of an interleukin-3 receptor gene: a member of a distinct receptor gene family.

N Itoh, S Yonehara, J Schreurs, D. Gorman, K Maruyama, A Ishii, I Yahara, K Arai, and A Miyajima (1990)
Science 247, 324-327
 |  Abstract »  |  PDF »

Signal transduction by the platelet-derived growth factor receptor.

L. Williams (1989)
Science 243, 1564-1570
 |  Abstract »  |  PDF »

Interleukin-11 Signals through the Formation of a Hexameric Receptor Complex.

V. A. Barton, M. A. Hall, K. R. Hudson, and J. K. Heath (2000)
J. Biol. Chem. 275, 36197-36203
 |  Abstract »  |  Full Text »  |  PDF »

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