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Science 8 July 1988:
Vol. 241. no. 4862, pp. 223 - 226
DOI: 10.1126/science.2968652
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Articles

Science, Vol 241, Issue 4862, 223-226
Copyright © 1988 by American Association for the Advancement of Science

articles

Amyloid beta protein precursor is possibly a heparan sulfate proteoglycan core protein

D Schubert, R Schroeder, M LaCorbiere, T Saitoh, and G Cole

Salk Institute for Biological Studies, San Diego, CA 92138.

The amyloid beta protein peptide is a major constituent of amyloid plaque cores in Alzheimer's disease and is apparently derived from a higher molecular weight precursor. It is now shown that the core protein of a heparan sulfate proteoglycan secreted from a nerve cell line (PC12) has an amino acid sequence and a size very similar to those of the amyloid beta protein precursor and that these molecules are antigenically related. This amyloid beta protein precursor-related protein is not found in the conditioned medium of a variant cell line (F3 PC12) that does not secrete heparan sulfate proteoglycan. The synaptic localization and metabolism of this class of proteoglycans are consistent with its potential involvement in central nervous system dysfunction.


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