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Science 8 July 1988: Vol. 241. no. 4862, pp. 215 - 218 DOI: 10.1126/science.2455346
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Articles
Science, Vol 241, Issue 4862, 215-218
Copyright © 1988 by American Association for the Advancement of Science
Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable hyperlipidemic rabbits
ME Haberland,
D Fong,
and
L Cheng
Department of Medicine, UCLA School of Medicine 90024.
It has been proposed that chemically reactive lipids released during lipid peroxidation convert low density lipoprotein (LDL), the major carrier of plasma cholesterol, to an abnormal form and that receptor-mediated clearance of this altered LDL produces cholesteryl ester deposition in macrophage-derived foam cells of atheroma. Immuno-cytochemical analyses now reveal the presence of protein modified by malondialdehyde, a peroxidative end product, which colocalizes with the extracellular deposition of apolipoprotein B-100 protein of LDL in atheroma from Watanabe heritable hyperlipidemic rabbits. These findings provide direct evidence for the existence in vivo of protein modified by a physiological product of lipid peroxidation within arterial lesions.
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Circulation
93, 672-682
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- Isolation and Characterization of Human Antioxidized LDL Autoantibodies.
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Arterioscler Thromb Vasc Biol
16, 222-229
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- Reduction of Serum Cholesterol Levels Alters Lesional Composition of Atherosclerotic Plaques : Effect of Pravastatin Sodium on Atherosclerosis in Mature WHHL Rabbits.
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Arterioscler Thromb Vasc Biol
15, 1938-1944
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- Increased Autoantibody Titers Against Epitopes of Oxidized LDL in LDL Receptor–Deficient Mice With Increased Atherosclerosis.
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Arterioscler Thromb Vasc Biol
15, 1569-1576
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- Inhibition of Lecithin-Cholesterol Acyltransferase and Modification of HDL Apolipoproteins by Aldehydes.
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Arterioscler Thromb Vasc Biol
15, 1599-1606
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- Effect of the Antioxidant N,N'-Diphenyl 1,4-Phenylenediamine (DPPD) on Atherosclerosis in ApoE-Deficient Mice.
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Arterioscler Thromb Vasc Biol
15, 1625-1630
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- Tissue Factor Pathway Inhibitor Activity Associated With LDL Is Inactivated by Cell- and Copper-Mediated Oxidation.
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Arterioscler Thromb Vasc Biol
15, 1121-1130
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- Immunologic Detection and Measurement of Hypochlorite-Modified LDL With Specific Monoclonal Antibodies.
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Arterioscler Thromb Vasc Biol
15, 982-989
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- The Response-to-Retention Hypothesis of Early Atherogenesis.
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Arterioscler Thromb Vasc Biol
15, 571-582
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- Generation, Characterization, and Histochemical Application of Monoclonal Antibodies Selectively Recognizing Oxidatively Modified ApoB-Containing Serum Lipoproteins.
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Arterioscler Thromb Vasc Biol
15, 704-713
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- Prevention of Tocopherol-mediated Peroxidation in Ubiquinol-10-free Human Low Density Lipoprotein.
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- Lysine Modification of LDL or Lipoprotein(a) by 4-Hydroxynonenal or Malondialdehyde Decreases Platelet Serotonin Secretion Without Affecting Platelet Aggregability and Eicosanoid Formation.
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Arch Intern Med
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Arterioscler Thromb Vasc Biol
15, 190-198
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- Vitamin E and Fatty Acid Intervention Does Not Attenuate the Progression of Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits.
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Arterioscler Thromb Vasc Biol
15, 290-297
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- Molecular studies on phospholipid-binding sites and cryptic epitopes appearing on {beta} 2-glycoprotein I structure recognized by anticardiolipin antibodies.
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Lupus
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- Oxidized Low Density Lipoprotein Decreases Macrophage Expression of Scavenger Receptor B-I.
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- Inhibition of Oxidized Low-density Lipoprotein-induced Apoptosis in Endothelial Cells by Nitric Oxide. PEROXYL RADICAL SCAVENGING AS AN ANTIAPOPTOTIC MECHANISM.
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