Science 8 July 1988: Vol. 241. no. 4862, pp. 202 - 205 DOI: 10.1126/science.3260404

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Articles

An update on nuclear calcium signalling.

M. D. Bootman, C. Fearnley, I. Smyrnias, F. MacDonald, and H. L. Roderick (2009)
J. Cell Sci. 122, 2337-2350
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the transcriptional regulation of the human MT1-MMP gene and association of risk reduction for focal-segmental glomerulosclerosis with two functional promoter SNPs.

A. Munkert, U. Helmchen, M. J. Kemper, M. Bubenheim, R. A. K. Stahl, and S. Harendza (2009)
Nephrol. Dial. Transplant. 24, 735-742
 |  Abstract »  |  Full Text »  |  PDF »

A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.

V. Orru, S. J. Tsai, B. Rueda, E. Fiorillo, S. M. Stanford, J. Dasgupta, J. Hartiala, L. Zhao, N. Ortego-Centeno, S. D'Alfonso, et al. (2009)
Hum. Mol. Genet. 18, 569-579
 |  Abstract »  |  Full Text »  |  PDF »

Calcineurin/NFAT Signaling Is Required for Neuregulin-Regulated Schwann Cell Differentiation.

S.-C. Kao, H. Wu, J. Xie, C.-P. Chang, J. A. Ranish, I. A. Graef, and G. R. Crabtree (2009)
Science 323, 651-654
 |  Abstract »  |  Full Text »  |  PDF »

Bursting into the Nucleus.

G. R. Crabtree and I. A. Graef (2008)
Science Signaling 1, pe54
 |  Abstract »  |  Full Text »  |  PDF »

Evolutionary computation for discovery of composite transcription factor binding sites.

G. B. Fogel, V. W. Porto, G. Varga, E. R. Dow, A. M. Craven, D. M. Powers, H. B. Harlow, E. W. Su, J. E. Onyia, and C. Su (2008)
Nucleic Acids Res. 36, e142
 |  Abstract »  |  Full Text »  |  PDF »

NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure.

R. J. Flockhart, B. L. Diffey, P. M. Farr, J. Lloyd, and N. J. Reynolds (2008)
FASEB J 22, 4218-4227
 |  Abstract »  |  Full Text »  |  PDF »

Immunosuppressive Effect of Isopropanol: Down-Regulation of Cytokine Production Results from the Alteration of Discrete Transcriptional Pathways in Activated Lymphocytes.

O. Desy, D. Carignan, M. Caruso, and P. O. de Campos-Lima (2008)
J. Immunol. 181, 2348-2355
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Transcription Factor NFAT by ADP-Ribosylation.

O. A. Olabisi, N. Soto-Nieves, E. Nieves, T. T. C. Yang, X. Yang, R. Y. L. Yu, H. Y. Suk, F. Macian, and C.-W. Chow (2008)
Mol. Cell. Biol. 28, 2860-2871
 |  Abstract »  |  Full Text »  |  PDF »

Cholecystokinin Activates Pancreatic Calcineurin-NFAT Signaling In Vitro and In Vivo.

G. T. Gurda, L. Guo, S.-H. Lee, J. D. Molkentin, and J. A. Williams (2008)
Mol. Biol. Cell 19, 198-206
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of NFAT-dependent gene expression by the RhoA signaling pathway in T cells.

W. S. Helms, J. L. Jeffrey, D. A. Holmes, M. B. Townsend, N. A. Clipstone, and L. Su (2007)
J. Leukoc. Biol. 82, 361-369
 |  Abstract »  |  Full Text »  |  PDF »

Selective Role of NFATc3 in Positive Selection of Thymocytes.

K. Cante-Barrett, M. M. Winslow, and G. R. Crabtree (2007)
J. Immunol. 179, 103-110
 |  Abstract »  |  Full Text »  |  PDF »

NF90 regulates inducible IL-2 gene expression in T cells.

L. Shi, W. R. Godfrey, J. Lin, G. Zhao, and P. N. Kao (2007)
J. Exp. Med. 204, 971-977
 |  Abstract »  |  Full Text »  |  PDF »

Accumulation of NFAT mediates IL-2 expression in memory, but not naive, CD4+ T cells.

O. Dienz, S. M. Eaton, T. J. Krahl, S. Diehl, C. Charland, J. Dodge, S. L. Swain, R. C. Budd, L. Haynes, and M. Rincon (2007)
PNAS 104, 7175-7180
 |  Abstract »  |  Full Text »  |  PDF »

Dynamic binding of Ku80, Ku70 and NF90 to the IL-2 promoter in vivo in activated T-cells.

L. Shi, D. Qiu, G. Zhao, B. Corthesy, S. Lees-Miller, W. H. Reeves, and P. N. Kao (2007)
Nucleic Acids Res. 35, 2302-2310
 |  Abstract »  |  Full Text »  |  PDF »

RSK2 Mediates Muscle Cell Differentiation through Regulation of NFAT3.

Y.-Y. Cho, K. Yao, A. M. Bode, H. R. Bergen III, B. J. Madden, S.-M. Oh, S. Ermakova, B. S. Kang, H. S. Choi, J.-H. Shim, et al. (2007)
J. Biol. Chem. 282, 8380-8392
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the nuclear export of the transcription factor NFATc1 by protein kinases after slow fibre type electrical stimulation of adult mouse skeletal muscle fibres.

T. Shen, Z. Cseresnyes, Y. Liu, W. R. Randall, and M. F. Schneider (2007)
J. Physiol. 579, 535-551
 |  Abstract »  |  Full Text »  |  PDF »

Basiliolides, a Class of Tetracyclic C19 Dilactones from Thapsia garganica, Release Ca2+ from the Endoplasmic Reticulum and Regulate the Activity of the Transcription Factors Nuclear Factor of Activated T Cells, Nuclear Factor-{kappa}B, and Activator Protein 1 in T Lymphocytes.

C. Navarrete, R. Sancho, F. J. Caballero, F. Pollastro, B. L. Fiebich, O. Sterner, G. Appendino, and E. Munoz (2006)
J. Pharmacol. Exp. Ther. 319, 422-430
 |  Abstract »  |  Full Text »  |  PDF »

Human immunodeficiency virus type 1 Tat increases cooperation between AP-1 and NFAT transcription factors in T cells.

A. M. Hidalgo-Estevez, E. Gonzalez, C. Punzon, and M. Fresno (2006)
J. Gen. Virol. 87, 1603-1612
 |  Abstract »  |  Full Text »  |  PDF »

NFAT Induces Breast Cancer Cell Invasion by Promoting the Induction of Cyclooxygenase-2.

G. K. Yiu and A. Toker (2006)
J. Biol. Chem. 281, 12210-12217
 |  Abstract »  |  Full Text »  |  PDF »

Activity- and Calcineurin-independent Nuclear Shuttling of NFATc1, but Not NFATc3, in Adult Skeletal Muscle Fibers.

T. Shen, Y. Liu, Z. Cseresnyes, A. Hawkins, W. R. Randall, and M. F. Schneider (2006)
Mol. Biol. Cell 17, 1570-1582
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of NFAT Activation by the Second Calcineurin Binding Site.

S. Martinez-Martinez, A. Rodriguez, M. D. Lopez-Maderuelo, I. Ortega-Perez, J. Vazquez, and J. M. Redondo (2006)
J. Biol. Chem. 281, 6227-6235
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Drosophila Genes Modulating Janus Kinase/Signal Transducer and Activator of Transcription Signal Transduction.

T. Mukherjee, U. Schafer, and M. P. Zeidler (2006)
Genetics 172, 1683-1697
 |  Abstract »  |  Full Text »  |  PDF »

The intracellular domain of CD44 promotes the fusion of macrophages.

W. Cui, J. Z. Ke, Q. Zhang, H.-Z. Ke, C. Chalouni, and A. Vignery (2006)
Blood 107, 796-805
 |  Abstract »  |  Full Text »  |  PDF »

Constrictor-induced translocation of NFAT3 in human and rat pulmonary artery smooth muscle.

A. Yaghi and S. M. Sims (2005)
Am J Physiol Lung Cell Mol Physiol 289, L1061-L1074
 |  Abstract »  |  Full Text »  |  PDF »

Kruppel-Like Factor 2, a Novel Immediate-Early Transcriptional Factor, Regulates IL-2 Expression in T Lymphocyte Activation.

J. Wu and J. B. Lingrel (2005)
J. Immunol. 175, 3060-3066
 |  Abstract »  |  Full Text »  |  PDF »

Calcium-dependent Activation of Interleukin-21 Gene Expression in T Cells.

H.-P. Kim, L. L. Korn, A. M. Gamero, and W. J. Leonard (2005)
J. Biol. Chem. 280, 25291-25297
 |  Abstract »  |  Full Text »  |  PDF »

Heat Shock Protein 60 Inhibits Th1-Mediated Hepatitis Model via Innate Regulation of Th1/Th2 Transcription Factors and Cytokines.

A. Zanin-Zhorov, R. Bruck, G. Tal, S. Oren, H. Aeed, R. Hershkoviz, I. R. Cohen, and O. Lider (2005)
J. Immunol. 174, 3227-3236
 |  Abstract »  |  Full Text »  |  PDF »

Cyclosporin A Inhibits Calcineurin/Nuclear Factor of Activated T-Cells Signaling and Induces Apoptosis in Retinoblastoma Cells.

L. A. Eckstein, K. R. Van Quill, S. K. Bui, M. S. Uusitalo, and J. M. O'Brien (2005)
Invest. Ophthalmol. Vis. Sci. 46, 782-790
 |  Abstract »  |  Full Text »  |  PDF »

Expression and regulation of NFAT (nuclear factors of activated T cells) in human CD34+ cells: down-regulation upon myeloid differentiation.

A. Kiani, I. Habermann, M. Haase, S. Feldmann, S. Boxberger, M. A. Sanchez-Fernandez, C. Thiede, M. Bornhauser, and G. Ehninger (2004)
J. Leukoc. Biol. 76, 1057-1065
 |  Abstract »  |  Full Text »  |  PDF »

Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes.

B. Fiedler and K. C Wollert (2004)
Cardiovasc Res 63, 450-457
 |  Abstract »  |  Full Text »  |  PDF »

Vav1: an oncogene that regulates specific transcriptional activation of T cells.

S. Katzav (2004)
Blood 103, 2443-2451
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of NFAT Specifically in T Cells Prevents Allergic Pulmonary Inflammation.

S. Diehl, T. Krahl, L. Rinaldi, R. Norton, C. G. Irvin, and M. Rincon (2004)
J. Immunol. 172, 3597-3603
 |  Abstract »  |  Full Text »  |  PDF »

Caffeic Acid Phenethyl Ester Inhibits T-Cell Activation by Targeting Both Nuclear Factor of Activated T-Cells and NF-{kappa}B Transcription Factors.

N. Marquez, R. Sancho, A. Macho, M. A. Calzado, B. L. Fiebich, and E. Munoz (2004)
J. Pharmacol. Exp. Ther. 308, 993-1001
 |  Abstract »  |  Full Text »  |  PDF »

Immunosuppressive Activity of Endovanilloids: N-Arachidonoyl-Dopamine Inhibits Activation of the NF-{kappa}B, NFAT, and Activator Protein 1 Signaling Pathways.

R. Sancho, A. Macho, L. de La Vega, M. A. Calzado, B. L. Fiebich, G. Appendino, and E. Munoz (2004)
J. Immunol. 172, 2341-2351
 |  Abstract »  |  Full Text »  |  PDF »

A mechanism underlying STAT4-mediated up-regulation of IFN-{gamma} induction inTCR-triggered T cells.

W.-R. Park, M. Nakahira, N. Sugimoto, Y. Bian, Y. Yashiro-Ohtani, X.-Y. Zhou, Y.-F. Yang, T. Hamaoka, and H. Fujiwara (2004)
Int. Immunol. 16, 295-302
 |  Abstract »  |  Full Text »  |  PDF »

Normal B-1a cell development requires B cell-intrinsic NFATc1 activity.

R. Berland and H. H. Wortis (2003)
PNAS 100, 13459-13464
 |  Abstract »  |  Full Text »  |  PDF »

Brain-Derived Neurotrophic Factor Activation of NFAT (Nuclear Factor of Activated T-Cells)-Dependent Transcription: A Role for the Transcription Factor NFATc4 in Neurotrophin-Mediated Gene Expression.

R. D. Groth and P. G. Mermelstein (2003)
J. Neurosci. 23, 8125-8134
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Factor of Activated T Cells 2 Transactivation in Mast Cells: A NOVEL ISOFORM-SPECIFIC TRANSACTIVATION DOMAIN CONFERS UNIQUE Fc{epsilon}RI RESPONSIVENESS.

M. B. Hock and M. A. Brown (2003)
J. Biol. Chem. 278, 26695-26703
 |  Abstract »  |  Full Text »  |  PDF »

A Constitutively Active NFATc1 Mutant Induces a Transformed Phenotype in 3T3-L1 Fibroblasts.

J. W. Neal and N. A. Clipstone (2003)
J. Biol. Chem. 278, 17246-17254
 |  Abstract »  |  Full Text »  |  PDF »

NFATc1 Mediates Vascular Endothelial Growth Factor-induced Proliferation of Human Pulmonary Valve Endothelial Cells.

E. N. Johnson, Y. M. Lee, T. L. Sander, E. Rabkin, F. J. Schoen, S. Kaushal, and J. Bischoff (2003)
J. Biol. Chem. 278, 1686-1692
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C{gamma}2 Is Essential for Specific Functions of Fc{epsilon}R and Fc{gamma}R.

R. Wen, S.-T. Jou, Y. Chen, A. Hoffmeyer, and D. Wang (2002)
J. Immunol. 169, 6743-6752
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase A Negatively Modulates the Nuclear Accumulation of NF-ATc1 by Priming for Subsequent Phosphorylation by Glycogen Synthase Kinase-3.

C. M. Sheridan, E. K. Heist, C. R. Beals, G. R. Crabtree, and P. Gardner (2002)
J. Biol. Chem. 277, 48664-48676
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Tat Protein-mediated Transactivation of the HIV-1 Long Terminal Repeat Promoter Is Potentiated by a Novel Nuclear Tat-interacting Protein of 110 kDa, Tip110.

Y. Liu, J. Li, B. O. Kim, B. S. Pace, and J. J. He (2002)
J. Biol. Chem. 277, 23854-23863
 |  Abstract »  |  Full Text »  |  PDF »

Grap Negatively Regulates T-Cell Receptor-Elicited Lymphocyte Proliferation and Interleukin-2 Induction.

R. Shen, Y.-B. Ouyang, C.-K. Qu, A. Alonso, L. Sperzel, T. Mustelin, M. H. Kaplan, and G.-S. Feng (2002)
Mol. Cell. Biol. 22, 3230-3236
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation.

X.-Y. Zhou, Y. Yashiro-Ohtani, M. Nakahira, W. R. Park, R. Abe, T. Hamaoka, M. Naramura, H. Gu, and H. Fujiwara (2002)
J. Immunol. 168, 3847-3854
 |  Abstract »  |  Full Text »  |  PDF »

Yin Yang 1, Oct1, and NFAT-4 Form Repeating, Cyclosporin-Sensitive Regulatory Modules Within the Murine CD21 Intronic Control Region.

M. D. Zabel, W. Wheeler, J. J. Weis, and J. H. Weis (2002)
J. Immunol. 168, 3341-3350
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Murine Nfatc1 Gene by NFATc2.

B. Zhou, R. Q. Cron, B. Wu, A. Genin, Z. Wang, S. Liu, P. Robson, and H. S. Baldwin (2002)
J. Biol. Chem. 277, 10704-10711
 |  Abstract »  |  Full Text »  |  PDF »

Calcineurin and hypertrophic heart disease: novel insights and remaining questions.

O. F Bueno, E. van Rooij, J. D Molkentin, P. A Doevendans, and L. J De Windt (2002)
Cardiovasc Res 53, 806-821
 |  Abstract »  |  Full Text »  |  PDF »

The IL-4 production capability of different strains of naive CD4+ T cells controls the direction of the Th cell response.

R. Yagi, W. Suzuki, N. Seki, M. Kohyama, T. Inoue, T. Arai, and M. Kubo (2002)
Int. Immunol. 14, 1-11
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of interferon-{gamma} gene expression by nuclear factor of activated T cells.

A. Kiani, F. J. Garcia-Cozar, I. Habermann, S. Laforsch, T. Aebischer, G. Ehninger, and A. Rao (2001)
Blood 98, 1480-1488
 |  Abstract »  |  Full Text »  |  PDF »

Evolutionary relationships among Rel domains indicate functional diversification by recombination.

I. A. Graef, J. M. Gastier, U. Francke, and G. R. Crabtree (2001)
PNAS 98, 5740-5745
 |  Abstract »  |  Full Text »  |  PDF »

Vav-Rac1-Mediated Activation of the c-Jun N-Terminal Kinase/c-Jun/AP-1 Pathway Plays a Major Role in Stimulation of the Distal NFAT Site in the Interleukin-2 Gene Promoter.

O. Kaminuma, M. Deckert, C. Elly, Y.-C. Liu, and A. Altman (2001)
Mol. Cell. Biol. 21, 3126-3136
 |  Abstract »  |  Full Text »

Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT).

A. Behrens, K. Sabapathy, I. Graef, M. Cleary, G. R. Crabtree, and E. F. Wagner (2001)
PNAS 98, 1769-1774
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Three nef-Defective Human Immunodeficiency Virus Type 1 Strains Associated with Long-Term Nonprogression.

D. I. Rhodes, L. Ashton, A. Solomon, A. Carr, D. Cooper, J. Kaldor, and N. Deacon (2000)
J. Virol. 74, 10581-10588
 |  Abstract »  |  Full Text »

Akt-dependent Cytokine Production in Mast Cells.

J. Kitaura, K. Asai, M. Maeda-Yamamoto, Y. Kawakami, U. Kikkawa, and T. Kawakami (2000)
J. Exp. Med. 192, 729-740
 |  Abstract »  |  Full Text »  |  PDF »

Lineage commitment in the immune system: the T helper lymphocyte grows up.

L. H. Glimcher and K. M. Murphy (2000)
Genes & Dev. 14, 1693-1711
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Involvement of Nuclear Factor of Activated T Cells Activation in UV Response. EVIDENCE FROM CELL CULTURE AND TRANSGENIC MICE.

C. Huang, P. Mattjus, W.-y. Ma, M. Rincon, N.-y. Chen, R. E. Brown, and Z. Dong (2000)
J. Biol. Chem. 275, 9143-9149
 |  Abstract »  |  Full Text »  |  PDF »

SURVEY AND SUMMARY A compilation of cellular transcription factor interactions with the HIV-1 LTR promoter.

L. A. Pereira, K. Bentley, A. Peeters, M. J Churchill, and N. J. Deacon (2000)
Nucleic Acids Res. 28, 663-668
 |  Abstract »  |  Full Text »  |  PDF »

Integration of Calcium and Cyclic AMP Signaling Pathways by 14-3-3.

C.-W. Chow and R. J. Davis (2000)
Mol. Cell. Biol. 20, 702-712
 |  Abstract »  |  Full Text »

The Nuclear Factor of Activated T Cells (NFAT) Transcription Factor NFATp (NFATc2) Is a Repressor of Chondrogenesis.

A. M. Ranger, L. C. Gerstenfeld, J. Wang, T. Kon, H. Bae, E. M. Gravallese, M. J. Glimcher, and L. H. Glimcher (2000)
J. Exp. Med. 191, 9-22
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Calcineurin Phosphatase Activity by a Calcineurin B Homologous Protein.

X. Lin, R. A. Sikkink, F. Rusnak, and D. L. Barber (1999)
J. Biol. Chem. 274, 36125-36131
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids.

A. Lepple-Wienhues, C. Belka, T. Laun, A. Jekle, B. Walter, U. Wieland, M. Welz, L. Heil, J. Kun, G. Busch, et al. (1999)
PNAS 96, 13795-13800
 |  Abstract »  |  Full Text »  |  PDF »

Multiple NF-ATc Isoforms with Individual Transcriptional Properties Are Synthesized in T Lymphocytes.

S. Chuvpilo, A. Avots, F. Berberich-Siebelt, J. Glockner, C. Fischer, A. Kerstan, C. Escher, I. Inashkina, F. Hlubek, E. Jankevics, et al. (1999)
J. Immunol. 162, 7294-7301
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Transcription Factor NFAT in Interleukin-2 Expression.

C.-W. Chow, M. Rincon, and R. J. Davis (1999)
Mol. Cell. Biol. 19, 2300-2307
 |  Abstract »  |  Full Text »  |  PDF »

NF-ATc Isoforms Are Differentially Expressed and Regulated in Murine T and Mast Cells.

M. A. Sherman, D. R. Powell, D. L. Weiss, and M. A. Brown (1999)
J. Immunol. 162, 2820-2828
 |  Abstract »  |  Full Text »  |  PDF »

An Essential Role for Nuclear Factor kappa B in Promoting Double Positive Thymocyte Apoptosis.

T. Hettmann, J. DiDonato, M. Karin, and J. M. Leiden (1999)
J. Exp. Med. 189, 145-158
 |  Abstract »  |  Full Text »  |  PDF »

Signaling through Calcium, Calcineurin, and NF-AT in Lymphocyte Activation and Development.

K. STANKUNAS, I.A. GRAEF, J.R. NEILSON, S.-H. PARK, and G.R. CRABTREE (1999)
Cold Spring Harb Symp Quant Biol 64, 505-516
 |  Abstract »  |  PDF »

Signal Integration by Transcription-factor Assemblies: Interactions of NF-AT1 and AP-1 on the IL-2 Promoter.

L. CHEN, A. RAO, and S.C. HARRISON (1999)
Cold Spring Harb Symp Quant Biol 64, 527-532
 |  Abstract »  |  PDF »

Tissue-specific Regulation of Cytokine Gene Expression.

I.-C. HO, J.I. KIM, S.J. SZABO, and L.H. GLIMCHER (1999)
Cold Spring Harb Symp Quant Biol 64, 573-584
 |  Abstract »  |  PDF »

The Roles of Nuclear Factor of Activated T Cells and Ying-Yang 1 in Activation-induced Expression of the Interferon-gamma Promoter in T Cells.

M. T. Sweetser, T. Hoey, Y.-L. Sun, W. M. Weaver, G. A. Price, and C. B. Wilson (1998)
J. Biol. Chem. 273, 34775-34783
 |  Abstract »  |  Full Text »  |  PDF »

A potential role for the nuclear factor of activated T cells family of transcriptional regulatory proteins in adipogenesis.

I-C. Ho, J. H.-J. Kim, J. W. Rooney, B. M. Spiegelman, and L. H. Glimcher (1998)
PNAS 95, 15537-15541
 |  Abstract »  |  Full Text »  |  PDF »

CsA-sensitive purine-box transcriptional regulator in bronchial epithelial cells contains NF45, NF90, and Ku.

Y. Aoki, G. Zhao, D. Qiu, L. Shi, and P. N. Kao (1998)
Am J Physiol Lung Cell Mol Physiol 275, L1164-L1172
 |  Abstract »  |  Full Text »  |  PDF »

Uncoupling Activation-Dependent HS1 Phosphorylation from Nuclear Factor of Activated T Cells Transcriptional Activation in Jurkat T Cells: Differential Signaling Through CD3 and the Costimulatory Receptors CD2 and CD28.

J. E. Hutchcroft, J. M. Slavik, H. Lin, T. Watanabe, and B. E. Bierer (1998)
J. Immunol. 161, 4506-4512
 |  Abstract »  |  Full Text »  |  PDF »

Carboxyl-Terminal 15-Amino Acid Sequence of NFATx1 Is Possibly Created by Tissue-Specific Splicing and Is Essential for Transactivation Activity in T Cells.

R. Imamura, E. S. Masuda, Y. Naito, S.-i. Imai, T. Fujino, T. Takano, K.-i. Arai, and N. Arai (1998)
J. Immunol. 161, 3455-3463
 |  Abstract »  |  Full Text »  |  PDF »

Naturally Occurring Human Immunodeficiency Virus Type 1 Long Terminal Repeats Have a Frequently Observed Duplication That Binds RBF-2 and Represses Transcription.

M. C. Estable, B. Bell, M. Hirst, and I. Sadowski (1998)
J. Virol. 72, 6465-6474
 |  Abstract »  |  Full Text »  |  PDF »

Th2-Specific Protein/DNA Interactions at the Proximal Nuclear Factor-AT Site Contribute to the Functional Activity of the Human IL-4 Promoter.

M. Li-Weber, P. Salgame, C. Hu, I. V. Davydov, O. Laur, S. Klevenz, and P. H. Krammer (1998)
J. Immunol. 161, 1380-1389
 |  Abstract »  |  Full Text »  |  PDF »

An NFAT-Dependent Enhancer Is Necessary for Anti-IgM-Mediated Induction of Murine CD5 Expression in Primary Splenic B Cells.

R. Berland and H. H. Wortis (1998)
J. Immunol. 161, 277-285
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Bruton's Tyrosine Kinase in Fcepsilon RI-dependent Mast Cell Degranulation and Cytokine Production.

D. Hata, Y. Kawakami, N. Inagaki, C. S. Lantz, T. Kitamura, W. N. Khan, M. Maeda-Yamamoto, T. Miura, W. Han, S. E. Hartman, et al. (1998)
J. Exp. Med. 187, 1235-1247
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of NF-kappa B and NFAT with the Interferon-gamma Promoter.

A. Sica, L. Dorman, V. Viggiano, M. Cippitelli, P. Ghosh, N. Rice, and H. A. Young (1997)
J. Biol. Chem. 272, 30412-30420
 |  Abstract »  |  Full Text »  |  PDF »

Selective Inhibition of Mitogen-induced Transactivation of the HIV Long Terminal Repeat by Carboxyamidotriazole. CALCIUM INFLUX BLOCKADE REPRESSES HIV-1 TRANSCRIPTIONAL ACTIVATION.

H. Yasui, W. Butscher, M. Cohen, N. Spriggs, R. Wersto, E. C. Kohn, L. Liotta, and K. Gardner (1997)
J. Biol. Chem. 272, 28762-28770
 |  Abstract »  |  Full Text »  |  PDF »

Cyclosporin A and FK506 Reduce Interleukin-5 mRNA Abundance by Inhibiting Gene Transcription.

F. G. Rolfe, J. E. Valentine, and W. A. Sewell (1997)
Am. J. Respir. Cell Mol. Biol. 17, 243-250
 |  Abstract »  |  Full Text »

Dual role of the nuclear factor of activated T cells insert region in DNA recognition and cooperative contacts to activator protein 1.

L. J. Sun, B. R. Peterson, and G. L. Verdine (1997)
PNAS 94, 4919-4924
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction..

C R Beals, N A Clipstone, S N Ho, and G R Crabtree (1997)
Genes & Dev. 11, 824-834
 |  Abstract »  |  PDF »

Constitutive Binding of the Transcription Factor Interleukin-2 (IL-2) Enhancer Binding Factor to the IL-2 Promoter.

A. Nirula, D. J. Moore, and R. B. Gaynor (1997)
J. Biol. Chem. 272, 7736-7745
 |  Abstract »  |  Full Text »  |  PDF »

A critical arginine residue mediates cooperativity in the contact interface between transcription factors NFAT and AP-1.

B. R. Peterson, L. J. Sun, and G. L. Verdine (1996)
PNAS 93, 13671-13676
 |  Abstract »  |  Full Text »  |  PDF »

Induction of NFAT-mediated Transcription by G(q)-coupled Receptors in Lymphoid and Non-lymphoid Cells.

V. Boss, D. J. Talpade, and T. J. Murphy (1996)
J. Biol. Chem. 271, 10429-10432
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Nuclear Factor of Activated T Cells in a Cyclosporin A-resistant Pathway.

P. Ghosh, A. Sica, M. Cippitelli, J. Subleski, R. Lahesmaa, H. A. Young, and N. R. Rice (1996)
J. Biol. Chem. 271, 7700-7704
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of the Interleukin-2 Gene in Normal Human Peripheral Blood T Cells.

C. C. W. Hughes and J. S. Pober (1996)
J. Biol. Chem. 271, 5369-5377
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Physical Interaction between Calcineurin and Nuclear Factor of Activated T Cells (NFATp).

S. Wesselborg, D. A. Fruman, J. K. Sagoo, B. E. Bierer, and S. J. Burakoff (1996)
J. Biol. Chem. 271, 1274-1277
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Repressive Element in the Proximal lck Promoter.

R. C. Muise-Helmericks and N. Rosen (1995)
J. Biol. Chem. 270, 27538-27543
 |  Abstract »  |  Full Text »  |  PDF »

Direct Demonstration of NFAT(p) Dephosphorylation and Nuclear Localization in Activated HT-2 Cells Using a Specific NFAT(p) Polyclonal Antibody.

V. A. Ruff and K. L. Leach (1995)
J. Biol. Chem. 270, 22602-22607
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of the Transcription Factor NFATp Inhibits Its DNA Binding Activity in Cyclosporin A-treated Human B and T Cells.

J. Park, N. R. Yaseen, P. G. Hogan, A. Rao, and S. Sharma (1995)
J. Biol. Chem. 270, 20653-20659
 |  Abstract »  |  Full Text »  |  PDF »

NFATc3, a Lymphoid-specific NFATc Family Member That Is Calcium-regulated and Exhibits Distinct DNA Binding Specificity.

S. N. Ho, D. J. Thomas, L. A. Timmerman, X. Li, U. Francke, and G. R. Crabtree (1995)
J. Biol. Chem. 270, 19898-19907
 |  Abstract »  |  Full Text »  |  PDF »

Definition of cis-Regulatory Elements of the Mouse Interleukin-5 Gene Promoter.

H. J. Lee, E. S. Masuda, N. Arai, K.-i. Arai, and T. Yokota (1995)
J. Biol. Chem. 270, 17541-17550
 |  Abstract »  |  Full Text »  |  PDF »

Fc[IMAGE]RI-mediated Induction of Nuclear Factor of Activated T-cells.

L. E. Hutchinson and M. A. McCloskey (1995)
J. Biol. Chem. 270, 16333-16338
 |  Abstract »  |  Full Text »  |  PDF »

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