Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 1 July 1988:
Vol. 241. no. 4861, pp. 84 - 86
DOI: 10.1126/science.3388021

Articles

Science, Vol 241, Issue 4861, 84-86
Copyright © 1988 by American Association for the Advancement of Science


articles

Evidence of estrogen receptors in normal human osteoblast-like cells

EF Eriksen, DS Colvard, NJ Berg, ML Graham, KG Mann, TC Spelsberg, and BL Riggs

Endocrine Research Unit, Mayo Clinic, Rochester, MN 55905.

In seven strains of cultured normal human osteoblast-like cells, a mean of 1615 molecules of tritium-labeled 17 beta-estradiol per cell nucleus could be bound to specific nuclear sites. The nuclear binding of the labeled steroid was temperature-dependent, steroid-specific, saturable, and cell type-specific. These are characteristics of biologically active estrogen receptors. Pretreatment with 10 nanomolar estradiol in vitro increased the specific nuclear binding of progesterone in four of six cell strains, indicating an induction of functional progesterone receptors. RNA blot analysis demonstrated the presence of messenger RNA for the human estrogen receptor. The data suggest that estrogen acts directly on human bone cells through a classical estrogen receptor-mediated mechanism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Bioconversion of norethisterone, a progesterone receptor agonist into estrogen receptor agonists in osteoblastic cells.
A. E Lemus, J. Enriquez, A. Hernandez, R. Santillan, and G. Perez-Palacios (2009)
J. Endocrinol. 200, 199-206
   Abstract »    Full Text »    PDF »
The novel estrogen receptor G-protein-coupled receptor 30 is expressed in human bone.
T. J Heino, A. S Chagin, and L. Savendahl (2008)
J. Endocrinol. 197, R1-R6
   Abstract »    Full Text »    PDF »
Bone Growth and Turnover in Progesterone Receptor Knockout Mice.
D. J. Rickard, U. T. Iwaniec, G. Evans, T. E. Hefferan, J. C. Hunter, K. M. Waters, J. P. Lydon, B. W. O'Malley, S. Khosla, T. C. Spelsberg, et al. (2008)
Endocrinology 149, 2383-2390
   Abstract »    Full Text »    PDF »
Novel Perspectives for Progesterone in Hormone Replacement Therapy, with Special Reference to the Nervous System.
M. Schumacher, R. Guennoun, A. Ghoumari, C. Massaad, F. Robert, M. El-Etr, Y. Akwa, K. Rajkowski, and E.-E. Baulieu (2007)
Endocr. Rev. 28, 387-439
   Abstract »    Full Text »    PDF »
Treatment-related osteoporosis in men with prostate cancer..
M. R. Smith (2006)
Clin. Cancer Res. 12, 6315s-6319s
   Abstract »    Full Text »    PDF »
The Biology of Human Sex Differences.
D. D. Federman (2006)
N. Engl. J. Med. 354, 1507-1514
   Full Text »    PDF »
Effect of oral contraceptives and hormone replacement therapy on bone mineral density in premenopausal and perimenopausal women: a systematic review.
S L Liu and C M Lebrun (2006)
Br. J. Sports Med. 40, 11-24
   Abstract »    Full Text »    PDF »
Genetic studies to identify genes underlying menopausal age.
H. S. Kok, K. M. van Asselt, Y. T. van der Schouw, P. H.M. Peeters, and C. Wijmenga (2005)
Hum. Reprod. Update 11, 483-493
   Abstract »    Full Text »    PDF »
A Randomized Placebo-Controlled Trial of Short-Term Graded Transdermal Estradiol in Healthy Gonadotropin-Releasing Hormone Agonist-Suppressed Pre- and Postmenopausal Women: Effects on Serum Markers of Bone Turnover, Insulin-Like Growth Factor-I, and Osteoclastogenic Mediators.
P. Y. Liu, K. A. Hoey, K. L. Mielke, J. D. Veldhuis, and S. Khosla (2005)
J. Clin. Endocrinol. Metab. 90, 1953-1960
   Abstract »    Full Text »    PDF »
Estrogen responsiveness of bone formation in vitro and altered bone phenotype in aged estrogen receptor-{alpha}-deficient male and female mice.
V. Parikka, Z. Peng, T. Hentunen, J. Risteli, T. Elo, H K. Vaananen, and P. Harkonen (2005)
Eur. J. Endocrinol. 152, 301-314
   Abstract »    Full Text »    PDF »
Endocrine Control of Body Composition in Infancy, Childhood, and Puberty.
J. D. Veldhuis, J. N. Roemmich, E. J. Richmond, A. D. Rogol, J. C. Lovejoy, M. Sheffield-Moore, N. Mauras, and C. Y. Bowers (2005)
Endocr. Rev. 26, 114-146
   Abstract »    Full Text »    PDF »
Hormone Replacement Therapy.
H. V. Lochner and T. A. Einhorn (2004)
J. Am. Acad. Ortho. Surg. 12, 291-294
   Full Text »    PDF »
Estrone Sulfate Is a Major Source of Local Estrogen Formation in Human Bone.
M. Muir, G. Romalo, L. Wolf, W. Elger, and H.-U. Schweikert (2004)
J. Clin. Endocrinol. Metab. 89, 4685-4692
   Abstract »    Full Text »    PDF »
Raloxifene to Prevent Gonadotropin-Releasing Hormone Agonist-Induced Bone Loss in Men with Prostate Cancer: A Randomized Controlled Trial.
M. R. Smith, M. A. Fallon, H. Lee, and J. S. Finkelstein (2004)
J. Clin. Endocrinol. Metab. 89, 3841-3846
   Abstract »    Full Text »    PDF »
Bicalutamide Monotherapy Versus Leuprolide Monotherapy for Prostate Cancer: Effects on Bone Mineral Density and Body Composition.
M. R. Smith, M. Goode, A. L. Zietman, F. J. McGovern, H. Lee, and J. S. Finkelstein (2004)
J. Clin. Oncol. 22, 2546-2553
   Abstract »    Full Text »    PDF »
Transcriptional Profiling of Estrogen-Regulated Gene Expression via Estrogen Receptor (ER) {alpha} or ER{beta} in Human Osteosarcoma Cells: Distinct and Common Target Genes for These Receptors.
F. Stossi, D. H. Barnett, J. Frasor, B. Komm, C. R. Lyttle, and B. S. Katzenellenbogen (2004)
Endocrinology 145, 3473-3486
   Abstract »    Full Text »    PDF »
Androgens and Bone.
D. Vanderschueren, L. Vandenput, S. Boonen, M. K. Lindberg, R. Bouillon, and C. Ohlsson (2004)
Endocr. Rev. 25, 389-425
   Abstract »    Full Text »    PDF »
Relationship of Estrogen Receptor Genotypes to Bone Mineral Density and to Rates of Bone Loss in Men.
S. Khosla, B. L. Riggs, E. J. Atkinson, A. L. Oberg, C. Mavilia, F. Del Monte, L. J. Melton III, and M. L. Brandi (2004)
J. Clin. Endocrinol. Metab. 89, 1808-1816
   Abstract »    Full Text »    PDF »
Effects of Sex Hormone Disturbances on Craniofacial Growth in Newborn Mice.
T. Fujita, J. Ohtani, M. Shigekawa, T. Kawata, M. Kaku, S. Kohno, K. Tsutsui, K. Tenjo, M. Motokawa, Y. Tohma, et al. (2004)
Journal of Dental Research 83, 250-254
   Abstract »    Full Text »    PDF »
Effects of Loss of Steroid Receptor Coactivator-1 on the Skeletal Response to Estrogen in Mice.
U. I. L. Modder, A. Sanyal, A. E. Kearns, J. D. Sibonga, E. Nishihara, J. Xu, B. W. O'Malley, E. L. Ritman, B. L. Riggs, T. C. Spelsberg, et al. (2004)
Endocrinology 145, 913-921
   Abstract »    Full Text »    PDF »
Luteinizing Hormone Receptor Knockout (LuRKO) Mice and Transgenic Human Chorionic Gonadotropin (hCG)-Overexpressing Mice (hCG {alpha}{beta}+) Have Bone Phenotypes.
S. J. Yarram, M. J. Perry, T. J. Christopher, K. Westby, N. L. Brown, T. Lamminen, S. B. Rulli, F.-P. Zhang, I. Huhtaniemi, J. R. Sandy, et al. (2003)
Endocrinology 144, 3555-3564
   Abstract »    Full Text »    PDF »
Estrogen Receptor-{alpha} Dependency of Estrogen's Stimulatory Action on Cancellous Bone Formation in Male Mice.
K. E. McDougall, M. J. Perry, R. L. Gibson, S. M. Colley, K. S. Korach, and J. H. Tobias (2003)
Endocrinology 144, 1994-1999
   Abstract »    Full Text »    PDF »
Differential Effects of Androgens and Estrogens on Bone Turnover in Normal Men.
B. Z. Leder, K. M. LeBlanc, D. A. Schoenfeld, R. Eastell, and J. S. Finkelstein (2003)
J. Clin. Endocrinol. Metab. 88, 204-210
   Abstract »    Full Text »    PDF »
Estrogens Activate Bone Morphogenetic Protein-2 Gene Transcription in Mouse Mesenchymal Stem Cells.
S. Zhou, G. Turgeman, S. E. Harris, D. C. Leitman, B. S. Komm, P. V. N. Bodine, and D. Gazit (2003)
Mol. Endocrinol. 17, 56-66
   Abstract »    Full Text »    PDF »
A Novel Promoter Is Involved in the Expression of Estrogen Receptor {alpha} in Human Testis and Epididymis.
H. Brand, M. Kos, S. Denger, G. Flouriot, J. Gromoll, F. Gannon, and G. Reid (2002)
Endocrinology 143, 3397-3404
   Abstract »    Full Text »    PDF »
Estrogen Receptor-Related Receptor {alpha} Impinges on the Estrogen Axis in Bone: Potential Function in Osteoporosis.
E. Bonnelye, V. Kung, C. Laplace, D. L. Galson, and J. E. Aubin (2002)
Endocrinology 143, 3658-3670
   Abstract »    Full Text »    PDF »
Cross-Talk between Bone Morphogenic Proteins and Estrogen Receptor Signaling.
T. Yamamoto, F. Saatcioglu, and T. Matsuda (2002)
Endocrinology 143, 2635-2642
   Abstract »    Full Text »    PDF »
Sex Steroids and the Construction and Conservation of the Adult Skeleton.
B. L. Riggs, S. Khosla, and L. J. Melton III (2002)
Endocr. Rev. 23, 279-302
   Abstract »    Full Text »    PDF »
Estrous-cycle-dependent Variation in Orthodontic Tooth Movement.
N. Haruyama, K. Igarashi, S. Saeki, M. Otsuka-Isoya, H. Shinoda, and H. Mitani (2002)
Journal of Dental Research 81, 406-410
   Abstract »    Full Text »    PDF »
Changes in Proinflammatory Cytokine Activity after Menopause.
J. Pfeilschifter, R. Koditz, M. Pfohl, and H. Schatz (2002)
Endocr. Rev. 23, 90-119
   Abstract »    Full Text »    PDF »
Production and Actions of Estrogens.
C. J. Gruber, W. Tschugguel, C. Schneeberger, and J. C. Huber (2002)
N. Engl. J. Med. 346, 340-352
   Full Text »    PDF »
Sex Steroids and Bone.
S.C. Manolagas, S. Kousteni, and R.L. Jilka (2002)
Recent Prog. Horm. Res. 57, 385-409
   Abstract »    Full Text »    PDF »
Minireview: The OPG/RANKL/RANK System.
S. Khosla (2001)
Endocrinology 142, 5050-5055
   Abstract »    Full Text »    PDF »
High Dietary Phytoestrogen Intake Is Associated with Higher Bone Mineral Density in Postmenopausal but Not Premenopausal Women.
J. Mei, S. S. C. Yeung, and A. W. C. Kung (2001)
J. Clin. Endocrinol. Metab. 86, 5217-5221
   Abstract »    Full Text »    PDF »
Mechanisms of Estrogen Action.
S. Nilsson, S. Makela, E. Treuter, M. Tujague, J. Thomsen, G. Andersson, E. Enmark, K. Pettersson, M. Warner, and J.-A. Gustafsson (2001)
Physiol Rev 81, 1535-1565
   Abstract »    Full Text »    PDF »
Bone Mass and Breast Cancer Risk in Older Women: Differences by Stage at Diagnosis.
J. M. Zmuda, J. A. Cauley, B.-M. Ljung, D. C. Bauer, S. R. Cummings, and L. H. Kuller (2001)
J Natl Cancer Inst 93, 930-936
   Abstract »    Full Text »    PDF »
17{beta}-Estradiol Stimulates Expression of Osteoprotegerin by a Mouse Stromal Cell Line, ST-2, via Estrogen Receptor-{{alpha}}.
M. Saika, D. Inoue, S. Kido, and T. Matsumoto (2001)
Endocrinology 142, 2205-2212
   Abstract »    Full Text »    PDF »
Fracture History and Risk of Breast and Endometrial Cancer.
P. A. Newcomb, A. Trentham-Dietz, K. M. Egan, L. Titus-Ernstoff, J. A. Baron, B. E. Storer, W. C. Willett, and M. J. Stampfer (2001)
Am. J. Epidemiol. 153, 1071-1078
   Abstract »    Full Text »    PDF »
The Orphan Nuclear Estrogen Receptor-Related Receptor {alpha} (Err{alpha}) Is Expressed Throughout Osteoblast Differentiation and Regulates Bone Formation in Vitro.
E. Bonnelye, L. Merdad, V. Kung, and J.E. Aubin (2001)
J. Cell Biol. 153, 971-984
   Abstract »    Full Text »    PDF »
Selective Delivery of Estradiol to Bone by Aspartic Acid Oligopeptide and Its Effects on Ovariectomized Mice.
K. Yokogawa, K. Miya, T. Sekido, Y. Higashi, M. Nomura, R. Fujisawa, K. Morito, Y. Masamune, Y. Waki, S. Kasugai, et al. (2001)
Endocrinology 142, 1228-1233
   Abstract »    Full Text »    PDF »
Menstrual History and Risk of Hip Fractures in Postmenopausal Women The Iowa Women's Health Study.
K. K. Nicodemus, A. R. Folsom, and K. E. Anderson (2001)
Am. J. Epidemiol. 153, 251-255
   Abstract »    Full Text »    PDF »
Anabolic Effect of Estrogen Replacement on Bone in Postmenopausal Women with Osteoporosis: Histomorphometric Evidence in a Longitudinal Study.
G. Khastgir, J. Studd, N. Holland, J. Alaghband-Zadeh, S. Fox, and J. Chow (2001)
J. Clin. Endocrinol. Metab. 86, 289-295
   Abstract »    Full Text »
Sex Steroids and Bone.
J. E. Compston (2001)
Physiol Rev 81, 419-447
   Abstract »    Full Text »    PDF »
Evidence of a linkage disequilibrium between polymorphisms in the human estrogen receptor {alpha} gene and their relationship to bone mass variation in postmenopausal Italian women.
L. Becherini, L. Gennari, L. Masi, R. Mansani, F. Massart, A. Morelli, A. Falchetti, S. Gonnelli, G. Fiorelli, A. Tanini, et al. (2000)
Hum. Mol. Genet. 9, 2043-2050
   Abstract »    Full Text »    PDF »
Progression of Aortic Calcification Is Associated With Metacarpal Bone Loss During Menopause : A Population-Based Longitudinal Study.
A. E. Hak, H. A. P. Pols, A. M. van Hemert, A. Hofman, and J. C. M. Witteman (2000)
Arterioscler Thromb Vasc Biol 20, 1926-1931
   Abstract »    Full Text »    PDF »
Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice.
O. Vidal, M. K. Lindberg, K. Hollberg, D. J. Baylink, G. Andersson, D. B. Lubahn, S. Mohan, J.-A. Gustafsson, and C. Ohlsson (2000)
PNAS 97, 5474-5479
   Abstract »    Full Text »    PDF »
Antiestrogens Specifically Up-Regulate Bone Morphogenetic Protein-4 Promoter Activity in Human Osteoblastic Cells.
A. van den Wijngaard, W. R. Mulder, R. Dijkema, C. J .C. Boersma, S. Mosselman, E. J. J. van Zoelen, and W. Olijve (2000)
Mol. Endocrinol. 14, 623-633
   Abstract »    Full Text »
Close Correlation between Estrogen Treatment and Renal Phosphate Reabsorption Capacity.
H. Uemura, M. Irahara, N. Yoneda, T. Yasui, K. Genjida, K.-i. Miyamoto, T. Aono, and E. Takeda (2000)
J. Clin. Endocrinol. Metab. 85, 1215-1219
   Abstract »    Full Text »
Low Levels of Estradiol Are Associated with Vertebral Fractures in Older Men, But Not Women: The Rancho Bernardo Study.
E. Barrett-Connor, J. E. Mueller, D. G. von Mühlen, G. A. Laughlin, D. L. Schneider, and D. J. Sartoris (2000)
J. Clin. Endocrinol. Metab. 85, 219-223
   Abstract »    Full Text »
Estrogen: Consequences and Implications of Human Mutations in Synthesis and Action.
(1999)
J. Clin. Endocrinol. Metab. 84, 4677-4694
   Abstract »    Full Text »
Lesson of the week Oestrogen and calcium homeostasis in women with hypoparathyroidism.
J. McIlroy, F. Dryburgh, J. Hinnie, R. Dargie, and A. Al-Rawi (1999)
BMJ 319, 1252-1253
   Full Text »
Detection of Estrogen Receptor {alpha} and {beta} Messenger Ribonucleic Acids in Adult Gonadotropin-Releasing Hormone Neurons.
M. J. Skynner, J. A. Sim, and A. E. Herbison (1999)
Endocrinology 140, 5195-5201
   Abstract »    Full Text »
Estrogen Prevents Glucocorticoid-Induced Apoptosis in Osteoblasts in Vivo and in Vitro.
A. Gohel, M.-B. McCarthy, and G. Gronowicz (1999)
Endocrinology 140, 5339-5347
   Abstract »    Full Text »
Estrogen Receptor Polymorphism Predicts the Onset of Natural and Surgical Menopause.
A. E. A. M. Weel, A. G. Uitterlinden, I. C. D. Westendorp, H. Burger, S. C. E. Schuit, A. Hofman, T. J. M. Helmerhorst, J. P. T. M. van Leeuwen, and H. A. P. Pols (1999)
J. Clin. Endocrinol. Metab. 84, 3146-3150
   Abstract »    Full Text »
Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?.
J. F. Couse and K. S. Korach (1999)
Endocr. Rev. 20, 358-417
   Abstract »    Full Text »
Estrogen has rapid tissue-specific effects on rat bone.
R. T. Turner, L. S. Kidder, M. Zhang, S. A. Harris, K. C. Westerlind, A. Maran, and T. J. Wronski (1999)
J Appl Physiol 86, 1950-1958
   Abstract »    Full Text »    PDF »
The Actions and Interactions of Sex Steroids and Growth Factors/Cytokines on the Skeleton.
T. C. Spelsberg, M. Subramaniam, B. L. Riggs, and S. Khosla (1999)
Mol. Endocrinol. 13, 819-828
   Full Text »
Osteoporosis: gender differences and similarities.
S Khosla, L J Melton III, and B L Riggs (1999)
Lupus 8, 393-396
   Abstract »    PDF »
Amenorrheic Bone Loss.
K. K. Miller and A. Klibanski (1999)
J. Clin. Endocrinol. Metab. 84, 1775-1783
   Full Text »
Effects of Gonadal Suppression on the Regulation of Parathyroid Hormone and 1,25-Dihydroxyvitamin D Secretion in Women.
J. S. Finkelstein and D. A. Schoenfeld (1999)
J. Clin. Endocrinol. Metab. 84, 2151-2156
   Abstract »    Full Text »
Testosterone Stimulates Insulin-Like Growth Factor-I and Insulin-Like Growth Factor-I-Receptor Gene Expression in the Mandibular Condyle--A Model of Endochondral Ossification.
G. Maor, Y. Segev, and M. Phillip (1999)
Endocrinology 140, 1901-1910
   Abstract »    Full Text »
Androgens and Osteocalcin during the Menstrual Cycle.
C. Massafra, C. De Felice, D. P. Agnusdei, D. Gioia, and F. Bagnoli (1999)
J. Clin. Endocrinol. Metab. 84, 971-974
   Abstract »    Full Text »
Vitamin K intake and hip fractures in women: a prospective study.
D. Feskanich, P. Weber, W. C Willett, H. Rockett, S. L Booth, and G. A Colditz (1999)
Am. J. Clinical Nutrition 69, 74-79
   Abstract »    Full Text »    PDF »
Human Osteogenesis Involves Differentiation-Dependent Increases in the Morphogenically Active 3' Alternative Splicing Variant of Acetylcholinesterase.
D. Grisaru, E. Lev-Lehman, M. Shapira, E. Chaikin, J. B. Lessing, A. Eldor, F. Eckstein, and H. Soreq (1999)
Mol. Cell. Biol. 19, 788-795
   Abstract »    Full Text »    PDF »
Localization of Estrogen Receptor-{alpha} in Human and Rabbit Skeletal Tissues.
V. Kusec, A. S. Virdi, R. Prince, and J. T. Triffitt (1998)
J. Clin. Endocrinol. Metab. 83, 2421-2428
   Abstract »    Full Text »
Modulation of Intestinal Estrogen Receptor by Ovariectomy, Estrogen and Growth Hormone.
C. Chen and D. N. Kalu (1998)
J. Pharmacol. Exp. Ther. 286, 328-333
   Abstract »    Full Text »
The Role of Estrogen Receptors and Androgen Receptors in Sex Steroid Regulation of B Lymphopoiesis.
G. Smithson, J. F. Couse, D. B. Lubahn, K. S. Korach, and P. W. Kincade (1998)
J. Immunol. 161, 27-34
   Abstract »    Full Text »    PDF »
Localization of Estrogen-receptor-related Antigen in Human Odontoblasts.
E.-L. Hietala, M. Larmas, and T. Salo (1998)
Journal of Dental Research 77, 1384-1387
   Abstract »    PDF »
Estrogen Receptor-{alpha} Is Developmentally Regulated during Osteoblast Differentiation and Contributes to Selective Responsiveness of Gene Expression.
P. V. N. Bodine, R. A. Henderson, J. Green, M. Aronow, T. Owen, G. S. Stein, J. B. Lian, and B. S. Komm (1998)
Endocrinology 139, 2048-2057
   Abstract »    Full Text »    PDF »
Expression of Functional Estrogen Receptors and Galanin Messenger Ribonucleic Acid in Immortalized Luteinizing Hormone-Releasing Hormone Neurons: Estrogenic Control of Galanin Gene Expression.
E. S. Shen, E. H. Meade, M. C. Perez, D. C. Deecher, A. Negro-Vilar, and F. J. Lopez (1998)
Endocrinology 139, 939-948
   Abstract »    Full Text »    PDF »
Osteoclasts from Human Giant Cell Tumors of Bone Lack Estrogen Receptors.
F. McL. Collier, W. H. Huang, W. R. Holloway, J. M. Hodge, M. T. Gillespie, L. L. Daniels, M. H. Zheng, and G. C. Nicholson (1998)
Endocrinology 139, 1258-1267
   Abstract »    Full Text »    PDF »
Serum Soluble Interleukin-6 Receptor and Biochemical Markers of Bone Metabolism Show Significant Variations During the Menstrual Cycle.
I. Gorai, Y. Taguchi, O. Chaki, R. K. M. Nakayama, B. C. Yang, S. Yokota, and H. Minaguchi (1998)
J. Clin. Endocrinol. Metab. 83, 326-332
   Abstract »    Full Text »
Isolation of Estrogen-Responsive Genes with a CpG Island Library.
T. Watanabe, S. Inoue, H. Hiroi, A. Orimo, H. Kawashima, and M. Muramatsu (1998)
Mol. Cell. Biol. 18, 442-449
   Abstract »    Full Text »
Augmentation of Bone Mineral Density in Hirsute Women.
S. Dagogo-Jack, N. Al-Ali, and M. Qurttom (1997)
J. Clin. Endocrinol. Metab. 82, 2821-2825
   Abstract »    Full Text »    PDF »
Physiological Action of Progesterone in Target Tissues.
J. D. Graham and C. L. Clarke (1997)
Endocr. Rev. 18, 502-519
   Abstract »    Full Text »    PDF »
The ERR-1 Orphan Receptor Is a Transcriptional Activator Expressed During Bone Development.
E. Bonnelye, J. M. Vanacker, T. Dittmar, A. Begue, X. Desbiens, D. T. Denhardt, J. E. Aubin, V. Laudet, and B. Fournier (1997)
Mol. Endocrinol. 11, 905-916
   Abstract »    Full Text »
Calcifying Subpopulation of Bovine Aortic Smooth Muscle Cells Is Responsive to 17ß-Estradiol.
M. Balica, K. Bostrom, V. Shin, K. Tillisch, and L. L. Demer (1997)
Circulation 95, 1954-1960
   Abstract »    Full Text »
Cross Genotype Sex Hormone Treatment in Two Cases of Hypogonadal Osteoporosis.
I. Vered, I. Kaiserman, B.-A. Sela, and J. Sack (1997)
J. Clin. Endocrinol. Metab. 82, 576-578
   Abstract »    Full Text »    PDF »
24R,25-(OH)2 Vitamin D3 Inhibits 1alpha ,25-(OH)2 Vitamin D3 and Testosterone Potentiation of Calcium Channels in Osteosarcoma Cells.
K. Takeuchi and S. E. Guggino (1996)
J. Biol. Chem. 271, 33335-33343
   Abstract »    Full Text »    PDF »
Bone Mineral Density and Risk of Breast Cancer in Older Women: The Study of Osteoporotic Fractures.
J. A. Cauley, F. L. Lucas, L. H. Kuller, M. T. Vogt, W. S. Browner, and S. R. Cummings (1996)
JAMA 276, 1404-1408
   Abstract »    PDF »
Rationale for Estrogen With Interrupted Progestin as a New Low-Dose Hormonal Replacement Therapy.
R. F. Casper, N. J. MacLusky, C. Vanin, and T. J. Brown (1996)
Reproductive Sciences 3, 225-234
   Abstract »    PDF »
Instructional Course Lectures, The American Academy of Orthopaedic Surgeons - Osteoporosis: Diagnosis and Treatment*{{dagger}}.
J. M. LANE, E. H. RILEY, and P. Z. WIRGANOWICZ (1996)
J. Bone Joint Surg. Am. 78, 618-32
   Full Text »
Molecular Cloning, Structure, and Expression of Mouse Estrogen-responsive Finger Protein Efp.
A. Orimo, S. Inoue, K. Ikeda, S. Noji, and M. Muramatsu (1995)
J. Biol. Chem. 270, 24406-24413
   Abstract »    Full Text »    PDF »
Cytokines and estrogen in bone: anti-osteoporotic effects.
M. Horowitz (1993)
Science 260, 626-627
   PDF »
1,25-dihydroxyvitamin D-responsive element and glucocorticoid repression in the osteocalcin gene.
N. Morrison, J Shine, J. Fragonas, V Verkest, M. McMenemy, and J. Eisman (1989)
Science 246, 1158-1161
   Abstract »    PDF »
Geriatrics.
H. J. Cohen and K. W. Lyles (1989)
JAMA 261, 2847-2848
   Abstract »    PDF »
ESTROGEN WORKS DIRECTLY ON BONES.
(1988)
Journal Watch (General) 1988, 8
   Full Text »
Estrogen binding, receptor mRNA, and biologic response in osteoblast-like osteosarcoma cells.
B. Komm, C. Terpening, D. Benz, K. Graeme, A Gallegos, M Korc, G. Greene, B. O'Malley, and M. Haussler (1988)
Science 241, 81-84
   Abstract »    PDF »
Impaired Estrogen Sensitivity in Bone by Inhibiting Both Estrogen Receptor alpha and beta Pathways.
S. Ogawa, M. Fujita, Y. Ishii, H. Tsurukami, M. Hirabayashi, K. Ikeda, A. Orimo, T. Hosoi, M. Ueda, T. Nakamura, et al. (2000)
J. Biol. Chem. 275, 21372-21379
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)