Related Content
Search Google Scholar for:
|
|
Science 1 July 1988:
Vol. 241. no. 4861, pp. 67 - 70
DOI: 10.1126/science.2838904
|
|
Articles
Science, Vol 241, Issue 4861, 67-70
Copyright © 1988 by American Association for the Advancement of Science
Brownian dynamics of cytochrome c and cytochrome c peroxidase association
SH Northrup,
JO Boles,
and
JC Reynolds
Department of Chemistry, Tennessee Technological University, Cookeville 38505.
Brownian dynamics computer simulations of the diffusional association of electron transport proteins cytochrome c (cyt c) and cytochrome c peroxidase (cyt c per) were performed. A highly detailed and realistic model of the protein structures and their electrostatic interactions was used that was based on an atomic-level spatial description. Several structural features played a role in enhancing and optimizing the electron transfer efficiency of this reaction. Favorable electrostatic interactions facilitated long-lived nonspecific encounters between the proteins that allowed the severe orientational criteria for reaction to be overcome by rotational diffusion during encounters. Thus a "reduction-in-dimensionality" effect operated. The proteins achieved plausible electron transfer orientations in a multitude of electrostatically stable encounter complexes, rather than in a single dominant complex.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Replica exchange simulations of transient encounter complexes in protein-protein association.
- Y. C. Kim, C. Tang, G. M. Clore, and G. Hummer (2008)
PNAS
105, 12855-12860
| Abstract »
| Full Text »
| PDF »
- From the Cover: Solution structure and dynamics of the complex between cytochrome c and cytochrome c peroxidase determined by paramagnetic NMR.
- A. N. Volkov, J. A. R. Worrall, E. Holtzmann, and M. Ubbink (2006)
PNAS
103, 18945-18950
| Abstract »
| Full Text »
| PDF »
- The Nature of Aqueous Tunneling Pathways Between Electron-Transfer Proteins.
- J. Lin, I. A. Balabin, and D. N. Beratan (2005)
Science
310, 1311-1313
| Abstract »
| Full Text »
| PDF »
- Crystal structure and characterization of a cytochrome c peroxidase-cytochrome c site-specific cross-link.
- M. Guo, B. Bhaskar, H. Li, T. P. Barrows, and T. L. Poulos (2004)
PNAS
101, 5940-5945
| Abstract »
| Full Text »
| PDF »
- Definition of the Interaction Domain for Cytochrome c on Cytochrome c Oxidase. II. RAPID KINETIC ANALYSIS OF ELECTRON TRANSFER FROM CYTOCHROME c TO RHODOBACTER SPHAEROIDES CYTOCHROME OXIDASE SURFACE MUTANTS.
- K. Wang, Y. Zhen, R. Sadoski, S. Grinnell, L. Geren, S. Ferguson-Miller, B. Durham, and F. Millett (1999)
J. Biol. Chem.
274, 38042-38050
| Abstract »
| Full Text »
| PDF »
- Definition of the Interaction Domain for Cytochrome c on Cytochrome c Oxidase. III. PREDICTION OF THE DOCKED COMPLEX BY A COMPLETE, SYSTEMATIC SEARCH.
- V. A. Roberts and M. E. Pique (1999)
J. Biol. Chem.
274, 38051-38060
| Abstract »
| Full Text »
| PDF »
- The Structure of an Electron Transfer Complex Containing a Cytochrome c and a Peroxidase.
- G. W. Pettigrew, S. Prazeres, C. Costa, N. Palma, L. Krippahl, I. Moura, and J. J. G. Moura (1999)
J. Biol. Chem.
274, 11383-11389
| Abstract »
| Full Text »
| PDF »
- Design of a Ruthenium-Cytochrome c Derivative to Measure Electron Transfer to the Initial Acceptor in Cytochrome c Oxidase.
- L. M. Geren, J. R. Beasley, B. R. Fine, A. J. Saunders, S. Hibdon, G. J. Pielak, B. Durham, and F. Millett (1995)
J. Biol. Chem.
270, 2466-2472
| Abstract »
| Full Text »
| PDF »
- Stern-volmer in reverse: 2:1 stoichiometry of the cytochrome c-cytochrome c peroxidase electron-transfer complex.
- J. Zhou and B. Hoffman (1994)
Science
265, 1693-1696
| Abstract »
| PDF »
- Crystal structure of a complex between electron transfer partners, cytochrome c peroxidase and cytochrome c.
- H Pelletier and J Kraut (1992)
Science
258, 1748-1755
| Abstract »
| PDF »
|
|
