Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 1 July 1988:
Vol. 241. no. 4861, pp. 58 - 62
DOI: 10.1126/science.2898810

Articles

Science, Vol 241, Issue 4861, 58-62
Copyright © 1988 by American Association for the Advancement of Science


articles

Purification and characterization of mouse hematopoietic stem cells

GJ Spangrude, S Heimfeld, and IL Weissman

Department of Pathology, Stanford University School of Medicine, CA 94305.

Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells.
B. J. Frisch, R. L. Porter, B. J. Gigliotti, A. J. Olm-Shipman, J. M. Weber, R. J. O'Keefe, C. T. Jordan, and L. M. Calvi (2009)
Blood 114, 4054-4063
   Abstract »    Full Text »    PDF »
Irving Weissman: Working for regenerative medicine.
N. LeBrasseur (2009)
J. Cell Biol. 187, 316-317
   Full Text »    PDF »
Developmental trajectories in early hematopoiesis.
C. Murre (2009)
Genes & Dev. 23, 2366-2370
   Abstract »    Full Text »    PDF »
Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes.
M. P. Lambert, Y. Wang, K. H. Bdeir, Y. Nguyen, M. A. Kowalska, and M. Poncz (2009)
Blood 114, 2290-2298
   Abstract »    Full Text »    PDF »
The leukemic stem cell niche: current concepts and therapeutic opportunities.
S. W. Lane, D. T. Scadden, and D. G. Gilliland (2009)
Blood 114, 1150-1157
   Abstract »    Full Text »    PDF »
Stem Cells in Drug Discovery, Tissue Engineering, and Regenerative Medicine: Emerging Opportunities and Challenges.
V. S. Nirmalanandhan and G. S. Sittampalam (2009)
J Biomol Screen 14, 755-768
   Abstract »    PDF »
Molecular dissection of the male germ cell lineage identifies putative spermatogonial stem cells in rhesus macaques.
B. P. Hermann, M. Sukhwani, D. R. Simorangkir, T. Chu, T. M. Plant, and K. E. Orwig (2009)
Hum. Reprod. 24, 1704-1716
   Abstract »    Full Text »    PDF »
Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential.
D. G. Kent, M. R. Copley, C. Benz, S. Wohrer, B. J. Dykstra, E. Ma, J. Cheyne, Y. Zhao, M. B. Bowie, Y. Zhao, et al. (2009)
Blood 113, 6342-6350
   Abstract »    Full Text »    PDF »
Expression of AA4.1 marks lymphohematopoietic progenitors in early mouse development.
T. Yamane, N. Hosen, H. Yamazaki, and I. L. Weissman (2009)
PNAS 106, 8953-8958
   Abstract »    Full Text »    PDF »
Withdrawal of Sex Steroids Reverses Age- and Chemotherapy-Related Defects in Bone Marrow Lymphopoiesis.
J. A. Dudakov, G. L. Goldberg, J. J. Reiseger, A. P. Chidgey, and R. L. Boyd (2009)
J. Immunol. 182, 6247-6260
   Abstract »    Full Text »    PDF »
Stem and progenitor cells for liver repopulation: can we standardise the process from bench to bedside?.
P Sancho-Bru, M Najimi, M Caruso, K Pauwelyn, T Cantz, S Forbes, T Roskams, M Ott, U Gehling, E Sokal, et al. (2009)
Gut 58, 594-603
   Abstract »    Full Text »    PDF »
Purified hematopoietic stem cell allografts reconstitute immunity superior to bone marrow.
G. J. Tsao, J. A. Allen, K. A. Logronio, L. C. Lazzeroni, and J. A. Shizuru (2009)
PNAS 106, 3288-3293
   Abstract »    Full Text »    PDF »
E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors.
C. L. Semerad, E. M. Mercer, M. A. Inlay, I. L. Weissman, and C. Murre (2009)
PNAS 106, 1930-1935
   Abstract »    Full Text »    PDF »
Stem cell concepts renew cancer research.
J. E. Dick (2008)
Blood 112, 4793-4807
   Abstract »    Full Text »    PDF »
Effects of p38 MAP Kinase Inhibitors on the Differentiation and Maturation of Erythroid Progenitors.
D. A. Dalmas, L. A. Tierney, C. Zhang, P. K. Narayanan, R. W. Boyce, L. W. Schwartz, K. S. Frazier, and M. S. Scicchitano (2008)
Toxicol Pathol 36, 958-971
   Abstract »    Full Text »    PDF »
Lin-Sca1+Kit- Bone Marrow Cells Contain Early Lymphoid-Committed Precursors That Are Distinct from Common Lymphoid Progenitors.
R. Kumar, V. Fossati, M. Israel, and H.-W. Snoeck (2008)
J. Immunol. 181, 7507-7513
   Abstract »    Full Text »    PDF »
Aging and cancer resistance in lymphoid progenitors are linked processes conferred by p16Ink4a and Arf.
R. A.J. Signer, E. Montecino-Rodriguez, O. N. Witte, and K. Dorshkind (2008)
Genes & Dev. 22, 3115-3120
   Abstract »    Full Text »    PDF »
Epithelial Stem Cells of the Prostate and Their Role in Cancer Progression.
R.U. Lukacs, D.A. Lawson, L. Xin, Y. Zong, I. Garraway, A.S. Goldstein, S. Memarzadeh, and O.N. Witte (2008)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
Establishment of a Normal Hematopoietic and Leukemia Stem Cell Hierarchy.
M.P. Chao, J. Seita, and I.L. Weissman (2008)
Cold Spring Harb Symp Quant Biol
   Abstract »    PDF »
A Quantitative Trait Locus on Chromosome 4 Affects Cycling of Hematopoietic Stem and Progenitor Cells through Regulation of TGF-{beta}2 Responsiveness.
S. Avagyan, L. Glouchkova, J. Choi, and H.-W. Snoeck (2008)
J. Immunol. 181, 5904-5911
   Abstract »    Full Text »    PDF »
The origins of the identification and isolation of hematopoietic stem cells, and their capability to induce donor-specific transplantation tolerance and treat autoimmune diseases.
I. L. Weissman and J. A. Shizuru (2008)
Blood 112, 3543-3553
   Abstract »    Full Text »    PDF »
Noggin Expands Neural Stem Cells in the Adult Hippocampus.
M. A. Bonaguidi, C.-Y. Peng, T. McGuire, G. Falciglia, K. T. Gobeske, C. Czeisler, and J. A. Kessler (2008)
J. Neurosci. 28, 9194-9204
   Abstract »    Full Text »    PDF »
Mesenchymal Progenitor Cell Research: Limitations and Recommendations.
R. Summer and A. Fine (2008)
Proceedings of the ATS 5, 707-710
   Abstract »    Full Text »    PDF »
CD97 is differentially expressed on murine hematopoietic stem-and progenitor-cells.
M. van Pel, H. Hagoort, J. Hamann, and W. E. Fibbe (2008)
Haematologica 93, 1137-1144
   Abstract »    Full Text »    PDF »
The intestinal stem cell.
N. Barker, M. van de Wetering, and H. Clevers (2008)
Genes & Dev. 22, 1856-1864
   Abstract »    Full Text »    PDF »
Bloodlines of haematopoietic stem cell research in Japan.
H. Ema and H. Nakauchi (2008)
Phil Trans R Soc B 363, 2089-2097
   Abstract »    Full Text »    PDF »
Survival of the Fittest: Cancer Stem Cells in Therapeutic Resistance and Angiogenesis.
C. E. Eyler and J. N. Rich (2008)
J. Clin. Oncol. 26, 2839-2845
   Abstract »    Full Text »    PDF »
Human Flt3 Is Expressed at the Hematopoietic Stem Cell and the Granulocyte/Macrophage Progenitor Stages to Maintain Cell Survival.
Y. Kikushige, G. Yoshimoto, T. Miyamoto, T. Iino, Y. Mori, H. Iwasaki, H. Niiro, K. Takenaka, K. Nagafuji, M. Harada, et al. (2008)
J. Immunol. 180, 7358-7367
   Abstract »    Full Text »    PDF »
Bone marrow side population cells are enriched for progenitors capable of myogenic differentiation.
E. S. Luth, S. J. Jun, M. K. Wessen, K. Liadaki, E. Gussoni, and L. M. Kunkel (2008)
J. Cell Sci. 121, 1426-1434
   Abstract »    Full Text »    PDF »
Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal, and adult hematopoietic tissues.
V. J. Jokubaitis, L. Sinka, R. Driessen, G. Whitty, D. N. Haylock, I. Bertoncello, I. Smith, B. Peault, M. Tavian, and P. J. Simmons (2008)
Blood 111, 4055-4063
   Abstract »    Full Text »    PDF »
Stem Cell Niche: Microenvironment and Beyond.
J. Zhang and L. Li (2008)
J. Biol. Chem. 283, 9499-9503
   Full Text »    PDF »
DNA Damage Signaling in Hematopoietic Cells: A Role for Mre11 Complex Repair of Topoisomerase Lesions.
M. Morales, Y. Liu, E. C. Laiakis, W. F. Morgan, S. D. Nimer, and J. H.J. Petrini (2008)
Cancer Res. 68, 2186-2193
   Abstract »    Full Text »    PDF »
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins.
K. Takeda, H. L. Aguila, N. S. Parikh, X. Li, K. Lamothe, L.-J. Duan, H. Takeda, F. S. Lee, and G.-H. Fong (2008)
Blood 111, 3229-3235
   Abstract »    Full Text »    PDF »
Developmental Fate Determination and Marker Discovery in Hematopoietic Stem Cell Biology Using Proteomic Fingerprinting.
E. Spooncer, N. Brouard, S. K. Nilsson, B. Williams, M. C. Liu, R. D. Unwin, D. Blinco, E. Jaworska, P. J. Simmons, and A. D. Whetton (2008)
Mol. Cell. Proteomics 7, 573-581
   Abstract »    Full Text »    PDF »
A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus.
U. B. Jensen, X. Yan, C. Triel, S.-H. Woo, R. Christensen, and D. M. Owens (2008)
J. Cell Sci. 121, 609-617
   Abstract »    Full Text »    PDF »
Telomeres, stem cells, and hematology.
P. M. Lansdorp (2008)
Blood 111, 1759-1766
   Abstract »    Full Text »    PDF »
CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells.
D. C. Weksberg, S. M. Chambers, N. C. Boles, and M. A. Goodell (2008)
Blood 111, 2444-2451
   Abstract »    Full Text »    PDF »
Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated.
R. P. Ertl, J. Chen, C. M. Astle, T. M. Duffy, and D. E. Harrison (2008)
Blood 111, 1709-1716
   Abstract »    Full Text »    PDF »
Signaling pathways governing stem-cell fate.
U. Blank, G. Karlsson, and S. Karlsson (2008)
Blood 111, 492-503
   Abstract »    Full Text »    PDF »
Involvement of CCR9 at multiple stages of adult T lymphopoiesis.
M. Svensson, J. Marsal, H. Uronen-Hansson, M. Cheng, W. Jenkinson, C. Cilio, S. E. W. Jacobsen, E. Sitnicka, G. Anderson, and W. W. Agace (2008)
J. Leukoc. Biol. 83, 156-164
   Abstract »    Full Text »    PDF »
The hematopoietic stem cell and its niche: a comparative view.
J. A. Martinez-Agosto, H. K.A. Mikkola, V. Hartenstein, and U. Banerjee (2007)
Genes & Dev. 21, 3044-3060
   Abstract »    Full Text »    PDF »
Cancer stem cell: target for anti-cancer therapy.
C. Tang, B. T. Ang, and S. Pervaiz (2007)
FASEB J 21, 3777-3785
   Abstract »    Full Text »    PDF »
Efficient Transplantation via Antibody-Based Clearance of Hematopoietic Stem Cell Niches.
A. Czechowicz, D. Kraft, I. L. Weissman, and D. Bhattacharya (2007)
Science 318, 1296-1299
   Abstract »    Full Text »    PDF »
Paving the road for lung stem cell biology: bronchioalveolar stem cells and other putative distal lung stem cells.
C. F. Kim (2007)
Am J Physiol Lung Cell Mol Physiol 293, L1092-L1098
   Abstract »    Full Text »    PDF »
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche.
Y.-Y. Jang and S. J. Sharkis (2007)
Blood 110, 3056-3063
   Abstract »    Full Text »    PDF »
Id1, but not Id3, directs long-term repopulating hematopoietic stem-cell maintenance.
S. S. Perry, Y. Zhao, L. Nie, S. W. Cochrane, Z. Huang, and X.-H. Sun (2007)
Blood 110, 2351-2360
   Abstract »    Full Text »    PDF »
Age-related defects in B lymphopoiesis underlie the myeloid dominance of adult leukemia.
R. A. J. Signer, E. Montecino-Rodriguez, O. N. Witte, J. McLaughlin, and K. Dorshkind (2007)
Blood 110, 1831-1839
   Abstract »    Full Text »    PDF »
Side Population Cells in the Mouse Thyroid Exhibit Stem/Progenitor Cell-Like Characteristics.
N. Hoshi, T. Kusakabe, B. J. Taylor, and S. Kimura (2007)
Endocrinology 148, 4251-4258
   Abstract »    Full Text »    PDF »
Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: clinical and therapeutic implications.
M. P. Lambert, L. Rauova, M. Bailey, M. C. Sola-Visner, M. A. Kowalska, and M. Poncz (2007)
Blood 110, 1153-1160
   Abstract »    Full Text »    PDF »
Isolation of an Adult Mouse Lung Mesenchymal Progenitor Cell Population.
R. Summer, K. Fitzsimmons, D. Dwyer, J. Murphy, and A. Fine (2007)
Am. J. Respir. Cell Mol. Biol. 37, 152-159
   Abstract »    Full Text »    PDF »
Th1- and Th2-Dependent Endothelial Progenitor Cell Recruitment and Angiogenic Switch in Asthma.
K. Asosingh, S. Swaidani, M. Aronica, and S. C. Erzurum (2007)
J. Immunol. 178, 6482-6494
   Abstract »    Full Text »    PDF »
Identification of Adiponectin as a Novel Hemopoietic Stem Cell Growth Factor.
L. DiMascio, C. Voermans, M. Uqoezwa, A. Duncan, D. Lu, J. Wu, U. Sankar, and T. Reya (2007)
J. Immunol. 178, 3511-3520
   Abstract »    Full Text »    PDF »
Chronic Suppression of Angiogenesis following Radiation Exposure Is Independent of Hematopoietic Reconstitution.
T. Udagawa, A. E. Birsner, M. Wood, and R. J. D'Amato (2007)
Cancer Res. 67, 2040-2045
   Abstract »    Full Text »    PDF »
Fate of Bone Marrow Stem Cells Transplanted into the Testis: Potential Implication for Men with Testicular Failure.
Y. Lue, K. Erkkila, P. Y. Liu, K. Ma, C. Wang, A. S. Hikim, and R. S. Swerdloff (2007)
Am. J. Pathol. 170, 899-908
   Abstract »    Full Text »    PDF »
Selective Thymus Settling Regulated by Cytokine and Chemokine Receptors.
B. A. Schwarz, A. Sambandam, I. Maillard, B. C. Harman, P. E. Love, and A. Bhandoola (2007)
J. Immunol. 178, 2008-2017
   Abstract »    Full Text »    PDF »
SSEA-4 identifies mesenchymal stem cells from bone marrow.
E. J. Gang, D. Bosnakovski, C. A. Figueiredo, J. W. Visser, and R. C. R. Perlingeiro (2007)
Blood 109, 1743-1751
   Abstract »    Full Text »    PDF »
Impact of Aging on Rat Bone Marrow-Derived Stem Cell Chondrogenesis.
H. Zheng, J. A. Martin, Y. Duwayri, G. Falcon, and J. A. Buckwalter (2007)
J. Gerontol. A Biol. Sci. Med. Sci. 62, 136-148
   Abstract »    Full Text »    PDF »
Isolation and functional characterization of murine prostate stem cells.
D. A. Lawson, L. Xin, R. U. Lukacs, D. Cheng, and O. N. Witte (2007)
PNAS 104, 181-186
   Abstract »    Full Text »    PDF »
Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS.
T. Sugiyama, R. T. Rodriguez, G. W. McLean, and S. K. Kim (2007)
PNAS 104, 175-180
   Abstract »    Full Text »    PDF »
Biology of bone marrow-derived endothelial cell precursors.
G. C. Schatteman, M. Dunnwald, and C. Jiao (2007)
Am J Physiol Heart Circ Physiol 292, H1-H18
   Abstract »    Full Text »    PDF »
Repair of the damaged heart by bone marrow cells: from experimental evidence to clinical hope..
K.-L. Ang, L. Takura Shenje, L. Srinivasan, and M. Galinanes (2006)
Ann. Thorac. Surg. 82, 1549-1558
   Abstract »    Full Text »    PDF »
Characterization, isolation, and differentiation of murine skin cells expressing hematopoietic stem cell markers.
S. Meindl, U. Schmidt, C. Vaculik, and A. Elbe-Burger (2006)
J. Leukoc. Biol. 80, 816-826
   Abstract »    Full Text »    PDF »
Normal hematopoiesis after conditional targeting of RXR{alpha} in murine hematopoietic stem/progenitor cells.
M. Ricote, C. S. Snyder, H.-Y. Leung, J. Chen, K. R. Chien, and C. K. Glass (2006)
J. Leukoc. Biol. 80, 850-861
   Abstract »    Full Text »    PDF »
The journey of developing hematopoietic stem cells..
H. K. A. Mikkola and S. H. Orkin (2006)
Development 133, 3733-3744
   Abstract »    Full Text »    PDF »
Small molecule-induced ablation and subsequent regeneration of larval zebrafish melanocytes.
C.-T. Yang and S. L. Johnson (2006)
Development 133, 3563-3573
   Abstract »    Full Text »    PDF »
Hematopoietic Stem Cells: The Paradigmatic Tissue-Specific Stem Cell.
D. Bryder, D. J. Rossi, and I. L. Weissman (2006)
Am. J. Pathol. 169, 338-346
   Abstract »    Full Text »    PDF »
Prolonged Cell Cycle Transit Is a Defining and Developmentally Conserved Hemopoietic Stem Cell Property.
J. M. Nygren, D. Bryder, and S. E. W. Jacobsen (2006)
J. Immunol. 177, 201-208
   Abstract »    Full Text »    PDF »
The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation.
C. Capron, Y. Lecluse, A. L. Kaushik, A. Foudi, C. Lacout, D. Sekkai, I. Godin, O. Albagli, I. Poullion, F. Svinartchouk, et al. (2006)
Blood 107, 4678-4686
   Abstract »    Full Text »    PDF »
Tracing the first waves of lymphopoiesis in mice.
T. Yokota, J. Huang, M. Tavian, Y. Nagai, J. Hirose, J.-C. Zuniga-Pflucker, B. Peault, and P. W. Kincade (2006)
Development 133, 2041-2051
   Abstract »    Full Text »    PDF »
Synergistic activity of the proteasome inhibitor PS-341 with non-myeloablative 153-Sm-EDTMP skeletally targeted radiotherapy in an orthotopic model of multiple myeloma.
A. Goel, A. Dispenzieri, S. M. Geyer, S. Greiner, K.-W. Peng, and S. J. Russell (2006)
Blood 107, 4063-4070
   Abstract »    Full Text »    PDF »
Hematopoietic-Osteoblastic Interactions in the Hematopoietic Stem Cell Niche.
L. M. Calvi (2006)
IBMS BoneKEy 3, 10-18
   Abstract »    Full Text »    PDF »
High-Density Lipoproteins Enhance Progenitor-Mediated Endothelium Repair in Mice.
C. Tso, G. Martinic, W.-H. Fan, C. Rogers, K.-A. Rye, and P. J. Barter (2006)
Arterioscler Thromb Vasc Biol 26, 1144-1149
   Abstract »    Full Text »    PDF »
Endothelial NO Synthase Deficiency Promotes Smooth Muscle Progenitor Cells in Association With Upregulation of Stromal Cell-Derived Factor-1{alpha} in a Mouse Model of Carotid Artery Ligation.
L.-N. Zhang, D. W. Wilson, V. da Cunha, M. E. Sullivan, R. Vergona, J. C. Rutledge, and Y.-X. Wang (2006)
Arterioscler Thromb Vasc Biol 26, 765-772
   Abstract »    Full Text »    PDF »
Lineage specification and plasticity in CD19- early B cell precursors.
L. L. Rumfelt, Y. Zhou, B. M. Rowley, S. A. Shinton, and R. R. Hardy (2006)
J. Exp. Med. 203, 675-687
   Abstract »    Full Text »    PDF »
Hematopoietic Stem Cells Provide Repair Functions after Laser-Induced Bruch's Membrane Rupture Model of Choroidal Neovascularization.
T. Chan-Ling, L. Baxter, A. Afzal, N. Sengupta, S. Caballero, E. Rosinova, and M. B. Grant (2006)
Am. J. Pathol. 168, 1031-1044
   Abstract »    Full Text »    PDF »
The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion.
L. M. Kamminga, L. V. Bystrykh, A. de Boer, S. Houwer, J. Douma, E. Weersing, B. Dontje, and G. de Haan (2006)
Blood 107, 2170-2179
   Abstract »    Full Text »    PDF »
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal.
C. C. Zhang, A. D. Steele, S. Lindquist, and H. F. Lodish (2006)
PNAS 103, 2184-2189
   Abstract »    Full Text »    PDF »
Stem cell markers: less is more!.
G. Van Zant (2006)
Blood 107, 855-856
   Full Text »    PDF »
Hematopoietic stem cells do not engraft with absolute efficiencies.
F. D. Camargo, S. M. Chambers, E. Drew, K. M. McNagny, and M. A. Goodell (2006)
Blood 107, 501-507
   Abstract »    Full Text »    PDF »
Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis.
Y. Arinobu, H. Iwasaki, M. F. Gurish, S.-i. Mizuno, H. Shigematsu, H. Ozawa, D. G. Tenen, K. F. Austen, and K. Akashi (2005)
PNAS 102, 18105-18110
   Abstract »    Full Text »    PDF »
Propensity of Adult Lymphoid Progenitors to Progress to DN2/3 Stage Thymocytes with Notch Receptor Ligation.
J. Huang, K. P. Garrett, R. Pelayo, J. C. Zuniga-Pflucker, H. T. Petrie, and P. W. Kincade (2005)
J. Immunol. 175, 4858-4865
   Abstract »    Full Text »    PDF »
Cardiac Stem Cells and Mechanisms of Myocardial Regeneration.
A. Leri, J. Kajstura, and P. Anversa (2005)
Physiol Rev 85, 1373-1416
   Abstract »    Full Text »    PDF »
A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis.
M. Rosu-Myles, E. Stewart, J. Trowbridge, C. Y. Ito, P. Zandstra, and M. Bhatia (2005)
J. Cell Sci. 118, 4343-4352
   Abstract »    Full Text »    PDF »
LY6A/E (SCA-1) Expression in the Mouse Testis.
M. P.A. van Bragt, N. Ciliberti, W. L. Stanford, D. G. de Rooij, and A. M.M. van Pelt (2005)
Biol Reprod 73, 634-638
   Abstract »    Full Text »    PDF »
Stem Cell Research: Paths to Cancer Therapies and Regenerative Medicine.
I. Weissman (2005)
JAMA 294, 1359-1366
   Abstract »    Full Text »    PDF »
Stem Cell Approaches for the Treatment of Renal Failure.
J. C. Brodie and H. D. Humes (2005)
Pharmacol. Rev. 57, 299-313
   Abstract »    Full Text »    PDF »
A novel stem-cell population in adult liver with potent hematopoietic-reconstitution activity.
D. N. Kotton, A. J. Fabian, and R. C. Mulligan (2005)
Blood 106, 1574-1580
   Abstract »    Full Text »    PDF »
Multiple Drug Resistance in Cancer Revisited: The Cancer Stem Cell Hypothesis.
V. S. Donnenberg and A. D. Donnenberg (2005)
J. Clin. Pharmacol. 45, 872-877
   Abstract »    Full Text »    PDF »
Cell intrinsic alterations underlie hematopoietic stem cell aging.
D. J. Rossi, D. Bryder, J. M. Zahn, H. Ahlenius, R. Sonu, A. J. Wagers, and I. L. Weissman (2005)
PNAS 102, 9194-9199
   Abstract »    Full Text »    PDF »
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size.
S. Stier, Y. Ko, R. Forkert, C. Lutz, T. Neuhaus, E. Grunewald, T. Cheng, D. Dombkowski, L. M. Calvi, S. R. Rittling, et al. (2005)
J. Exp. Med. 201, 1781-1791
   Abstract »    Full Text »    PDF »
Prevention of Type 1 Diabetes with Major Histocompatibility Complex-Compatible and Nonmarrow Ablative Hematopoietic Stem Cell Transplants.
G. F. Beilhack, R. R. Landa, M. A. Masek, and J. A. Shizuru (2005)
Diabetes 54, 1770-1779
   Abstract »    Full Text »    PDF »
Murine hematopoietic stem cells change their surface phenotype during ex vivo expansion.
C. C. Zhang and H. F. Lodish (2005)
Blood 105, 4314-4320
   Abstract »    Full Text »    PDF »
Sca-1 expression identifies stem cells in the proximal region of prostatic ducts with high capacity to reconstitute prostatic tissue.
P. E. Burger, X. Xiong, S. Coetzee, S. N. Salm, D. Moscatelli, K. Goto, and E. L. Wilson (2005)
PNAS 102, 7180-7185
   Abstract »    Full Text »    PDF »
Hematopoietic cells maintain hematopoietic fates upon entering the brain.
M. Massengale, A. J. Wagers, H. Vogel, and I. L. Weissman (2005)
J. Exp. Med. 201, 1579-1589
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)