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Science 1 July 1988:
Vol. 241. no. 4861, pp. 58 - 62
DOI: 10.1126/science.2898810
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Articles

Science, Vol 241, Issue 4861, 58-62
Copyright © 1988 by American Association for the Advancement of Science

articles

Purification and characterization of mouse hematopoietic stem cells

GJ Spangrude, S Heimfeld, and IL Weissman

Department of Pathology, Stanford University School of Medicine, CA 94305.

Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers. These cells can proliferate and differentiate with approximately unit efficiency into myelomonocytic cells, B cells, or T cells. Thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.


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