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Science 1 July 1988:
Vol. 241. no. 4861, pp. 42 - 52
DOI: 10.1126/science.3291115

Articles

Science, Vol 241, Issue 4861, 42-52
Copyright © 1988 by American Association for the Advancement of Science


articles

The protein kinase family: conserved features and deduced phylogeny of the catalytic domains

SK Hanks, AM Quinn, and T Hunter

Molecular Biology Laboratory, Salk Institute for Biological Studies, San Diego, CA 92138.

In recent years, members of the protein kinase family have been discovered at an accelerated pace. Most were first described, not through the traditional biochemical approach of protein purification and enzyme assay, but as putative protein kinase amino acid sequences deduced from the nucleotide sequences of molecularly cloned genes or complementary DNAs. Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.


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R. S. Sawhney, M. M. Cookson, B. Sharma, J. Hauser, and M. G. Brattain (2004)
J. Biol. Chem. 279, 47379-47390
   Abstract »    Full Text »    PDF »
Cyclin-Dependent Kinase-9: An RNAPII Kinase at the Nexus of Cardiac Growth and Death Cascades.
M. Sano and M. D. Schneider (2004)
Circ. Res. 95, 867-876
   Abstract »    Full Text »    PDF »
The geminivirus nuclear shuttle protein is a virulence factor that suppresses transmembrane receptor kinase activity.
E. P.B. Fontes, A. A. Santos, D. F. Luz, A. J. Waclawovsky, and J. Chory (2004)
Genes & Dev. 18, 2545-2556
   Abstract »    Full Text »    PDF »
Inhibition of Heat Shock Protein 90, a Novel RET/PTC1-associated Protein, Increases Radioiodide Accumulation in Thyroid Cells.
D. K. Marsee, A. Venkateswaran, H. Tao, D. Vadysirisack, Z. Zhang, D. D. Vandre, and S. M. Jhiang (2004)
J. Biol. Chem. 279, 43990-43997
   Abstract »    Full Text »    PDF »
Overexpression of Constitutive Differential Growth 1 Gene, Which Encodes a RLCKVII-Subfamily Protein Kinase, Causes Abnormal Differential and Elongation Growth after Organ Differentiation in Arabidopsis.
H. Muto, N. Yabe, T. Asami, K. Hasunuma, and K. T. Yamamoto (2004)
Plant Physiology 136, 3124-3133
   Abstract »    Full Text »    PDF »
Biochemical Characterization of the Tobacco 42-kD Protein Kinase Activated by Osmotic Stress.
A. Kelner, I. Pekala, S. Kaczanowski, G. Muszynska, D. G. Hardie, and G. Dobrowolska (2004)
Plant Physiology 136, 3255-3265
   Abstract »    Full Text »    PDF »
ORF36 Protein Kinase of Kaposi's Sarcoma Herpesvirus Activates the c-Jun N-terminal Kinase Signaling Pathway.
M. S. Hamza, R. A. Reyes, Y. Izumiya, R. Wisdom, H.-J. Kung, and P. A. Luciw (2004)
J. Biol. Chem. 279, 38325-38330
   Abstract »    Full Text »    PDF »
Phosphorylation of Y845 on the Epidermal Growth Factor Receptor Mediates Binding to the Mitochondrial Protein Cytochrome c Oxidase Subunit II.
J. L. Boerner, M. L. Demory, C. Silva, and S. J. Parsons (2004)
Mol. Cell. Biol. 24, 7059-7071
   Abstract »    Full Text »    PDF »
Vitamin C Is a Kinase Inhibitor: Dehydroascorbic Acid Inhibits I{kappa}B{alpha} Kinase {beta}.
J. M. Carcamo, A. Pedraza, O. Borquez-Ojeda, B. Zhang, R. Sanchez, and D. W. Golde (2004)
Mol. Cell. Biol. 24, 6645-6652
   Abstract »    Full Text »    PDF »
A Tobacco Calcium/Calmodulin-binding Protein Kinase Functions as a Negative Regulator of Flowering.
W. Hua, L. Zhang, S. Liang, R. L. Jones, and Y.-T. Lu (2004)
J. Biol. Chem. 279, 31483-31494
   Abstract »    Full Text »    PDF »
Receptor Internalization-Independent Activation of Smad2 in Activin Signaling.
Y. Zhou, S. Scolavino, S. F. Funderburk, L. F. Ficociello, X. Zhang, and A. Klibanski (2004)
Mol. Endocrinol. 18, 1818-1826
   Abstract »    Full Text »    PDF »
Characterization of a Novel Calcium/Calmodulin-Dependent Protein Kinase from Tobacco.
L. Ma, S. Liang, R. L. Jones, and Y.-T. Lu (2004)
Plant Physiology 135, 1280-1293
   Abstract »    Full Text »    PDF »
Characterization of a Eukaryotic-Like Tyrosine Protein Kinase Expressed by the Shiga Toxin-Encoding Bacteriophage 933W.
J. S. Tyler and D. I. Friedman (2004)
J. Bacteriol. 186, 3472-3479
   Abstract »    Full Text »    PDF »



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