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Science 1 July 1988: Vol. 241. no. 4861, pp. 42 - 52 DOI: 10.1126/science.3291115
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Articles
Science, Vol 241, Issue 4861, 42-52
Copyright © 1988 by American Association for the Advancement of Science
The protein kinase family: conserved features and deduced phylogeny of the catalytic domains
SK Hanks,
AM Quinn,
and
T Hunter
Molecular Biology Laboratory, Salk Institute for Biological Studies, San Diego, CA 92138.
In recent years, members of the protein kinase family have been discovered at an accelerated pace. Most were first described, not through the traditional biochemical approach of protein purification and enzyme assay, but as putative protein kinase amino acid sequences deduced from the nucleotide sequences of molecularly cloned genes or complementary DNAs. Phylogenetic mapping of the conserved protein kinase catalytic domains can serve as a useful first step in the functional characterization of these newly identified family members.
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- Inhibition of Ca2+-Independent Phospholipase A2 Results in Insufficient Insulin Secretion and Impaired Glucose Tolerance.
- K. Song, X. Zhang, C. Zhao, N. T. Ang, and Z. A. Ma (2005)
Mol. Endocrinol.
19, 504-515
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- The Yeast Par-1 Homologs Kin1 and Kin2 Show Genetic and Physical Interactions with Components of the Exocytic Machinery.
- M. Elbert, G. Rossi, and P. Brennwald (2005)
Mol. Biol. Cell
16, 532-549
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- The Unique C-terminal Tail of the Mitogen-activated Protein Kinase ERK5 Regulates Its Activation and Nuclear Shuttling.
- M. Buschbeck and A. Ullrich (2005)
J. Biol. Chem.
280, 2659-2667
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- Activation of the protein kinase PKR by short double-stranded RNAs with single-stranded tails.
- X. ZHENG and P. C. BEVILACQUA (2004)
RNA
10, 1934-1945
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- Differential Requirement for Cell Fusion and Virion Formation in the Pathogenesis of Varicella-Zoster Virus Infection in Skin and T Cells.
- J. Besser, M. Ikoma, K. Fabel, M. H. Sommer, L. Zerboni, C. Grose, and A. M. Arvin (2004)
J. Virol.
78, 13293-13305
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- The conserved kinase UNC-51 acts with VAB-8 and UNC-14 to regulate axon outgrowth in C. elegans.
- T. Lai and G. Garriga (2004)
Development
131, 5991-6000
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- Autocrine Transforming Growth Factor {alpha} Regulates Cell Adhesion by Multiple Signaling via Specific Phosphorylation Sites of p70S6 Kinase in Colon Cancer Cells.
- R. S. Sawhney, M. M. Cookson, B. Sharma, J. Hauser, and M. G. Brattain (2004)
J. Biol. Chem.
279, 47379-47390
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- Cyclin-Dependent Kinase-9: An RNAPII Kinase at the Nexus of Cardiac Growth and Death Cascades.
- M. Sano and M. D. Schneider (2004)
Circ. Res.
95, 867-876
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- The geminivirus nuclear shuttle protein is a virulence factor that suppresses transmembrane receptor kinase activity.
- E. P.B. Fontes, A. A. Santos, D. F. Luz, A. J. Waclawovsky, and J. Chory (2004)
Genes & Dev.
18, 2545-2556
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- Inhibition of Heat Shock Protein 90, a Novel RET/PTC1-associated Protein, Increases Radioiodide Accumulation in Thyroid Cells.
- D. K. Marsee, A. Venkateswaran, H. Tao, D. Vadysirisack, Z. Zhang, D. D. Vandre, and S. M. Jhiang (2004)
J. Biol. Chem.
279, 43990-43997
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- Overexpression of Constitutive Differential Growth 1 Gene, Which Encodes a RLCKVII-Subfamily Protein Kinase, Causes Abnormal Differential and Elongation Growth after Organ Differentiation in Arabidopsis.
- H. Muto, N. Yabe, T. Asami, K. Hasunuma, and K. T. Yamamoto (2004)
Plant Physiology
136, 3124-3133
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- Biochemical Characterization of the Tobacco 42-kD Protein Kinase Activated by Osmotic Stress.
- A. Kelner, I. Pekala, S. Kaczanowski, G. Muszynska, D. G. Hardie, and G. Dobrowolska (2004)
Plant Physiology
136, 3255-3265
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- ORF36 Protein Kinase of Kaposi's Sarcoma Herpesvirus Activates the c-Jun N-terminal Kinase Signaling Pathway.
- M. S. Hamza, R. A. Reyes, Y. Izumiya, R. Wisdom, H.-J. Kung, and P. A. Luciw (2004)
J. Biol. Chem.
279, 38325-38330
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- Phosphorylation of Y845 on the Epidermal Growth Factor Receptor Mediates Binding to the Mitochondrial Protein Cytochrome c Oxidase Subunit II.
- J. L. Boerner, M. L. Demory, C. Silva, and S. J. Parsons (2004)
Mol. Cell. Biol.
24, 7059-7071
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- Vitamin C Is a Kinase Inhibitor: Dehydroascorbic Acid Inhibits I{kappa}B{alpha} Kinase {beta}.
- J. M. Carcamo, A. Pedraza, O. Borquez-Ojeda, B. Zhang, R. Sanchez, and D. W. Golde (2004)
Mol. Cell. Biol.
24, 6645-6652
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- A Tobacco Calcium/Calmodulin-binding Protein Kinase Functions as a Negative Regulator of Flowering.
- W. Hua, L. Zhang, S. Liang, R. L. Jones, and Y.-T. Lu (2004)
J. Biol. Chem.
279, 31483-31494
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- Receptor Internalization-Independent Activation of Smad2 in Activin Signaling.
- Y. Zhou, S. Scolavino, S. F. Funderburk, L. F. Ficociello, X. Zhang, and A. Klibanski (2004)
Mol. Endocrinol.
18, 1818-1826
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- Characterization of a Novel Calcium/Calmodulin-Dependent Protein Kinase from Tobacco.
- L. Ma, S. Liang, R. L. Jones, and Y.-T. Lu (2004)
Plant Physiology
135, 1280-1293
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- Characterization of a Eukaryotic-Like Tyrosine Protein Kinase Expressed by the Shiga Toxin-Encoding Bacteriophage 933W.
- J. S. Tyler and D. I. Friedman (2004)
J. Bacteriol.
186, 3472-3479
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