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Science 24 June 1988:
Vol. 240. no. 4860, pp. 1784 - 1786
DOI: 10.1126/science.3289118
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Articles

Science, Vol 240, Issue 4860, 1784-1786
Copyright © 1988 by American Association for the Advancement of Science

articles

Astrocyte mitogen inhibitor related to epidermal growth factor receptor

M Nieto-Sampedro

Department of Psychobiology, University of California, Irvine 92717.

Epidermal growth factor (EGF) is a well-characterized polypeptide hormone with diverse biological activities, including stimulation of astrocyte division. A soluble astrocyte mitogen inhibitor, immunologically related to the EGF receptor, is present in rat brain. Injury to the brain causes a time-dependent reduction in the levels of this inhibitor and the concomitant appearance of EGF receptor on the astrocyte surface. Intracerebral injection of antibody capable of binding the inhibitor caused the appearance of numerous reactive astrocytes. EGF receptor-related inhibitors may play a key role in the control of glial cell division in both normal and injured brain.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Intragenic Mutation Analysis of the Human Epidermal Growth Factor Receptor (EGFR) Gene in Malignant Human Oral Keratinocytes.
S. Shintani, K. Matsuo, C. C. Crohin, J. McBride, T. Tsuji, R. B. Donoff, M. Posner, R. Todd, and D. T.W. Wong (1999)
Cancer Res. 59, 4142-4147
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Serum sErbB1 and Epidermal Growth Factor Levels As Tumor Biomarkers in Women with Stage III or IV Epithelial Ovarian Cancer.
A. T. Baron, J. M. Lafky, C. H. Boardman, S. Balasubramaniam, V. J. Suman, K. C. Podratz, and N. J. Maihle (1999)
Cancer Epidemiol. Biomarkers Prev. 8, 129-137
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Science. ISSN 0036-8075 (print), 1095-9203 (online)