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Science 17 June 1988:
Vol. 240. no. 4859, pp. 1664 - 1666
DOI: 10.1126/science.2837826
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Articles

Science, Vol 240, Issue 4859, 1664-1666
Copyright © 1988 by American Association for the Advancement of Science

articles

Intracellular injection of cAMP induces a long-term reduction of neuronal K+ currents

KP Scholz and JH Byrne

Department of Neurobiology and Anatomy, University of Texas Medical School, Houston 77225.

Intracellular signals that trigger long-term (24-hour) changes in membrane currents in identified neurons of Aplysia have been examined in order to understand the cellular mechanisms underlying long-term sensitization. Adenosine 3',5'-monophosphate (cAMP) was directly injected into individual sensory neurons to mimic the effects of sensitization training at the single cell level. Potassium currents of these cells were reduced 24 hours after injection of cAMP; these currents were similar to those reduced 24 hours after behavioral sensitization. These results suggest that cAMP is part of the intracellular signal that induces long-term sensitization in Aplysia.


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