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Science 10 June 1988:
Vol. 240. no. 4858, pp. 1529 - 1531
DOI: 10.1126/science.2836952
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Articles

Science, Vol 240, Issue 4858, 1529-1531
Copyright © 1988 by American Association for the Advancement of Science

articles

Two classes of PDGF receptor recognize different isoforms of PDGF

CE Hart, JW Forstrom, JD Kelly, RA Seifert, RA Smith, R Ross, MJ Murray, and DF Bowen-Pope

Department of Pathology, University of Washington, Seattle 98195.

Previous studies involving platelet-derived growth factor (PDGF) have been based on the premise that a single cell-surface receptor binds all three isoforms of PDGF (AA, BB, and AB). It is now shown that two populations of PDGF receptor exist and can be distinguished by their ligand binding specificity. The B receptor binds only the BB dimer, whereas the A/B receptor binds AA, BB, and AB dimers. Human dermal fibroblasts appear to express seven times as much B receptor as A/B receptor. The B receptor is responsible for most PDGF receptor phosphorylation.


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