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Science 10 June 1988:
Vol. 240. no. 4858, pp. 1522 - 1525
DOI: 10.1126/science.2836951
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Articles

Science, Vol 240, Issue 4858, 1522-1525
Copyright © 1988 by American Association for the Advancement of Science

articles

Characterization of a noncytopathic HIV-2 strain with unusual effects on CD4 expression

LA Evans, J Moreau, K Odehouri, H Legg, A Barboza, C Cheng-Mayer, and JA Levy

Department of Medicine, University of California, San Francisco 94143.

A new isolate of the human immunodeficiency virus type 2, designated HIV-2UC1, was recovered from an Ivory Coast patient with normal lymphocyte numbers who died with neurologic symptoms. Like some HIV-1 isolates, HIV-2UC1 grows rapidly to high titers in human peripheral blood lymphocytes and macrophages and has a differential ability to productively infect established human cell lines of lymphocytic and monocytic origin. Moreover, infection with this isolate also appears to involve the CD4 antigen. However, unlike other HIV isolates, HIV-2UC1 does not cause cytopathic effects in susceptible T cells nor does it lead to loss of CD4 antigen expression on the cell surface. These results indicate that HIV-2 may be found in individuals with neurologic symptoms and that the biological characteristics of this heterogeneous subgroup can differ from those typical of HIV-1.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Single Amino Acid of the Human Immunodeficiency Virus Type 2 Capsid Affects Its Replication in the Presence of Cynomolgus Monkey and Human TRIM5{alpha}s.
H. Song, E. E. Nakayama, M. Yokoyama, H. Sato, J. A. Levy, and T. Shioda (2007)
J. Virol. 81, 7280-7285
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Rapid loss of CD4+ T cells in human-PBL-SCID mice by noncytopathic HIV isolates.
D. Mosier, R. Gulizia, P. MacIsaac, B. Torbett, and J. Levy (1993)
Science 260, 689-692
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Acquired Immune Deficiency Syndrome (AIDS): literature, geographical origins and global patterns.
M.R. Smallman-Raynor and A.D. Cliff (1990)
Progress in Human Geography 14, 157-213
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Differential effects of nef on HIV replication: implications for viral pathogenesis in the host.
C Cheng-Mayer, P Iannello, K Shaw, P. Luciw, and J. Levy (1989)
Science 246, 1629-1632
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The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4.
S. Schnittman, M. Psallidopoulos, H. Lane, L Thompson, M Baseler, F Massari, C. Fox, N. Salzman, and A. Fauci (1989)
Science 245, 305-308
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The Fc and not CD4 receptor mediates antibody enhancement of HIV infection in human cells.
J Homsy, M Meyer, M Tateno, S Clarkson, and J. Levy (1989)
Science 244, 1357-1360
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Human Immunodeficiency Viruses and the Pathogenesis of AIDS.
J. A. Levy (1989)
JAMA 261, 2997-3006
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