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Science 10 June 1988:
Vol. 240. no. 4858, pp. 1453 - 1459
DOI: 10.1126/science.3131880
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Articles

Science, Vol 240, Issue 4858, 1453-1459
Copyright © 1988 by American Association for the Advancement of Science

articles

Drosophila melanogaster as an experimental organism

GM Rubin

Department of Biochemistry, University of California, Berkeley 94720.

The fruit fly Drosophila melanogaster has been used as an experimental organism in studies of genetics since the early 1900s. It is now widely used not only in classical and molecular genetics but also, with many new biochemical, cell biological, and physiological techniques, to research problems requiring a multidisciplinary approach, such as those of developmental biology and neurobiology.


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Glial and Neuronal Functions of the Drosophila Homolog of the Human SWI/SNF Gene ATR-X (DATR-X) and the jing Zinc-Finger Gene Specify the Lateral Positioning of Longitudinal Glia and Axons.
X. Sun, T. Morozova, and M. Sonnenfeld (2006)
Genetics 173, 1397-1415
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Activity Affects Dendritic Shape and Synapse Elimination during Steroid Controlled Dendritic Retraction in Manduca sexta.
C. Duch and T. Mentel (2004)
J. Neurosci. 24, 9826-9837
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Integrative Physiology and Functional Genomics of Epithelial Function in a Genetic Model Organism.
J. A. T. DOW and S. A. DAVIES (2003)
Physiol Rev 83, 687-729
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Characterization of the Drosophila melanogaster alkali-metal/proton exchanger (NHE) gene family.
M. E. Giannakou and J. A. T. Dow (2001)
J. Exp. Biol. 204, 3703-3716
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Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS.
A. Bulfone, E. Menguzzato, V. Broccoli, A. Marchitiello, C. Gattuso, M. Mariani, G. G. Consalez, S. Martinez, A. Ballabio, and S. Banfi (2000)
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A Genetic Screen for Novel Components of the Ras/Mitogen-Activated Protein Kinase Signaling Pathway That Interact With the yan Gene of Drosophila Identifies split ends, a New RNA Recognition Motif-Containing Protein.
I. Rebay, F. Chen, F. Hsiao, P. A. Kolodziej, B. H. Kuang, T. Laverty, C. Suh, M. Voas, A. Williams, and G. M. Rubin (2000)
Genetics 154, 695-712
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A homeobox gene, vax2, controls the patterning of the eye dorsoventral axis.
A. M. Barbieri, G. Lupo, A. Bulfone, M. Andreazzoli, M. Mariani, F. Fougerousse, G. G. Consalez, G. Borsani, J. S. Beckmann, G. Barsacchi, et al. (1999)
PNAS 96, 10729-10734
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Isolation and characterization of a leucokinin-like peptide of Drosophila melanogaster.
S Terhzaz, F. O'Connell, V. Pollock, L Kean, S. Davies, J. Veenstra, and J. Dow (1999)
J. Exp. Biol. 202, 3667-3676
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Loss of the Tight Junction MAGUK ZO-1 in Breast Cancer : Relationship to Glandular Differentiation and Loss ofHeterozygosity.
K. B. Hoover, S.-Y. Liao, and P. J. Bryant (1998)
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Analysis and Inactivation of vha55, the Gene Encoding the Vacuolar ATPase B-subunit in Drosophila melanogaster Reveals a Larval Lethal Phenotype.
S. A. Davies, S. F. Goodwin, D. C. Kelly, Z. Wang, M. A. Sozen, K. Kaiser, and J. A.T. Dow (1996)
J. Biol. Chem. 271, 30677-30684
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canoe encodes a novel protein containing a GLGF/DHR motif and functions with Notch and scabrous in common developmental pathways in Drosophila..
H Miyamoto, I Nihonmatsu, S Kondo, R Ueda, S Togashi, K Hirata, Y Ikegami, and D Yamamoto (1995)
Genes & Dev. 9, 612-625
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Toward cloning and mapping the genome of Drosophila.
J Merriam, M Ashburner, D. Hartl, and F. Kafatos (1991)
Science 254, 221-225
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Glial cell diversification in the rat optic nerve.
M. Raff (1989)
Science 243, 1450-1455
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Axon guidance and the patterning of neuronal projections in vertebrates.
J Dodd and T. Jessell (1988)
Science 242, 692-699
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Growth cone guidance in insects: fasciclin II is a member of the immunoglobulin superfamily.
A. Harrelson and C. Goodman (1988)
Science 242, 700-708
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