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Science 3 June 1988: Vol. 240. no. 4857, pp. 1328 - 1331 DOI: 10.1126/science.3131879
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Articles
Science, Vol 240, Issue 4857, 1328-1331
Copyright © 1988 by American Association for the Advancement of Science
Expression of c-fos protein in brain: metabolic mapping at the cellular level
SM Sagar,
FR Sharp,
and
T Curran
Department of Neurology, University of California, San Francisco.
The proto-oncogene c-fos is expressed in neurons in response to direct stimulation by growth factors and neurotransmitters. In order to determine whether the c-fos protein (Fos) and Fos-related proteins can be induced in response to polysynaptic activation, rat hindlimb motor/sensory cortex was stimulated electrically and Fos expression examined immunohistochemically. Three hours after the onset of stimulation, focal nuclear Fos staining was seen in motor and sensory thalamus, pontine nuclei, globus pallidus, and cerebellum. Moreover, 24-hour water deprivation resulted in Fos expression in paraventricular and supraoptic nuclei. Fos immunohistochemistry therefore provides a cellular method to label polysynaptically activated neurons and thereby map functional pathways.
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- Central Fos expression in fetal and adult sheep after intraperitoneal hypertonic saline.
- A. Caston-Balderrama, M. J. M. Nijland, T. J. McDonald, and M. G. Ross (1999)
Am J Physiol Heart Circ Physiol
276, H725-H735
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- Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems.
- Y. Date, Y. Ueta, H. Yamashita, H. Yamaguchi, S. Matsukura, K. Kangawa, T. Sakurai, M. Yanagisawa, and M. Nakazato (1999)
PNAS
96, 748-753
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- c-Fos induction in spinal cord neurons after renal arterial or venous occlusion.
- M. P. Rosas-Arellano, L. P. Solano-Flores, and J. Ciriello (1999)
Am J Physiol Regulatory Integrative Comp Physiol
276, R120-R127
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- Effects of 5-Hydroxytryptamine2 Receptor Antagonism on the Behavioral Activation and Immediate Early Gene Expression Induced by Dizocilpine.
- M. F. O'Neill, C. A. Hicks, G. Shaw, T. Parameswaran, G. P. Cardwell, and M. J. O'Neill (1998)
J. Pharmacol. Exp. Ther.
287, 839-846
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- Expression of Fos in the Rat Forebrain Following Experimental Tooth Movement.
- T. Yamashiro, K. Satoh, K. Nakagawa, H. Moriyama, T. Yagi, and K. Takada (1998)
Journal of Dental Research
77, 1920-1925
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- Daily rhythms in Fos activity in the rat ventrolateral preoptic area and midline thalamic nuclei.
- C. M. Novak and A. A. Nunez (1998)
Am J Physiol Regulatory Integrative Comp Physiol
275, R1620-R1626
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- Relationship between Fos Production and Classical Fear Conditioning: Effects of Novelty, Latent Inhibition, and Unconditioned Stimulus Preexposure.
- J. Radulovic, J. Kammermeier, and J. Spiess (1998)
J. Neurosci.
18, 7452-7461
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- Ischemic Preconditioning and Brain Tolerance: Temporal Histological and Functional Outcomes, Protein Synthesis Requirement, and Interleukin-1 Receptor Antagonist and Early Gene Expression • Editorial Comment.
- F. C. Barone, R. F. White, P. A. Spera, J. Ellison, R. W. Currie, X. Wang, G. Z. Feuerstein, and N. J. Rothwell (1998)
Stroke
29, 1937-1951
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- Regulation of c-fos Expression by EGF and GnRH in Specific Anterior Pituitary Cells from Proestrous Female Rats.
- J. L. Armstrong and G. V. Childs (1998)
J. Histochem. Cytochem.
46, 935-944
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- Metabolic inhibition increases feeding and brain Fos-like immunoreactivity as a function of diet.
- C. C. Horn and M. I. Friedman (1998)
Am J Physiol Regulatory Integrative Comp Physiol
275, R448-R459
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- Role of the Nucleus Raphe Magnus in Antinociception Produced by ABT-594: Immediate Early Gene Responses Possibly Linked to Neuronal Nicotinic Acetylcholine Receptors on Serotonergic Neurons.
- R. S. Bitner, A. L. Nikkel, P. Curzon, S. P. Arneric, A. W. Bannon, and M. W. Decker (1998)
J. Neurosci.
18, 5426-5432
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- Medullary c-Fos activation in rats after ingestion of a satiating meal.
- L. Rinaman, E. A. Baker, G. E. Hoffman, E. M. Stricker, and J. G. Verbalis (1998)
Am J Physiol Regulatory Integrative Comp Physiol
275, R262-R268
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- Activation of ventrolateral preoptic neurons by the somnogen prostaglandin D2.
- T. Scammell, D. Gerashchenko, Y. Urade, H. Onoe, C. Saper, and O. Hayaishi (1998)
PNAS
95, 7754-7759
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- Divergence in the Expression of Molecular Markers of Neuronal Activation in the Parvocellular Paraventricular Nucleus of the Hypothalamus Evoked by Alcohol Administration via Different Routes.
- K. M. Ogilvie, S. Lee, and C. Rivier (1998)
J. Neurosci.
18, 4344-4352
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- Duodenal nutrient infusions differentially affect sham feeding and Fos expression in rat brain stem.
- C. B. Phifer and H.-R. Berthoud (1998)
Am J Physiol Regulatory Integrative Comp Physiol
274, R1725-R1733
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- Hypothalamic Ventromedial Nuclei Amplify Circadian Rhythms: Do They Contain a Food-Entrained Endogenous Oscillator?.
- S. Choi, L. S. Wong, C. Yamat, and M. F. Dallman (1998)
J. Neurosci.
18, 3843-3852
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- Immunocytochemical Localization of Fos in Perfused Nonhuman Primate Brain Tissue: Fixation and Antisera Selection.
- A. L. CastonBalderrama, J. L. Cameron, and G. E. Hoffman (1998)
J. Histochem. Cytochem.
46, 547-556
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- Intrastriatal Mesencephalic Grafts Affect Neuronal Activity in Basal Ganglia Nuclei and Their Target Structures in a Rat Model of Parkinson's Disease.
- N. Nakao, M. Ogura, K. Nakai, and T. Itakura (1998)
J. Neurosci.
18, 1806-1817
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