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Science 3 June 1988:
Vol. 240. no. 4857, pp. 1324 - 1326
DOI: 10.1126/science.2453924
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Articles

Science, Vol 240, Issue 4857, 1324-1326
Copyright © 1988 by American Association for the Advancement of Science

articles

Epitopes recognized by human T cells map within the conserved part of the GP190 of P. falciparum

A Crisanti, HM Muller, C Hilbich, F Sinigaglia, H Matile, M McKay, J Scaife, K Beyreuther, and H Bujard

Zentrum fur Molekulare Biologie, Heidelberg, Germany.

In a study aimed at developing a vaccine against the asexual blood stages of Plasmodium falciparum, two T cell epitopes were identified within a nonpolymorphic region of gp190 of Plasmodium falciparum merozoites. The two epitopes, which were revealed by deletion analysis, stimulated human T cell clones. Peptides containing sequences of the epitopes stimulated the cloned T cells and peripheral blood mononuclear cells (PBMC) from malaria-infected individuals. Moreover, the T cell clones responded to 11 different Plasmodium falciparum isolates in culture, showing that the epitopes are recognized in native parasites.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Different Regions of the Malaria Merozoite Surface Protein 1 of Plasmodium chabaudi Elicit Distinct T-Cell and Antibody Isotype Responses.
S. J. Quin and J. Langhorne (2001)
Infect. Immun. 69, 2245-2251
   Abstract »    Full Text »    PDF »
Allelic Diversity and Antibody Recognition of Plasmodium falciparum Merozoite Surface Protein 1 during Hypoendemic Malaria Transmission in the Brazilian Amazon Region.
L. A. Da Silveira, M. L. Dorta, E. A. S. Kimura, A. M. Katzin, F. Kawamoto, K. Tanabe, and M. U. Ferreira (1999)
Infect. Immun. 67, 5906-5916
   Abstract »    Full Text »    PDF »
Immunization of Aotus Monkeys with Recombinant Plasmodium falciparum Hybrid Proteins Does Not Reproducibly Result in Protection from Malaria Infection.
C. H. M. Kocken, E. Hundt, B. Knapp, D. Brazel, B. Enders, D. L. Narum, J. A. M. Wubben, and A. W. Thomas (1998)
Infect. Immun. 66, 373-375
   Abstract »    Full Text »    PDF »


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