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Science 3 June 1988:
Vol. 240. no. 4857, pp. 1321 - 1323
DOI: 10.1126/science.3375816
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Articles

Science, Vol 240, Issue 4857, 1321-1323
Copyright © 1988 by American Association for the Advancement of Science

articles

Potassium salt microinjection into Xenopus oocytes mimics gonadotropin treatment

YT Lau, RR Yassin, and SB Horowitz

Department of Physiology and Biophysics, Michigan Cancer-Foundation, Detroit 48201.

Gonadotropin stimulates protein synthesis and growth in ovarian oocytes. The hormone is also known to modify transfollicular K+ fluxes and is now shown to cause increased intraoocytic K+ activity (aK). The hormone's effect on aK was duplicated by microinjecting K+ salts into oocytes which were incubated in paraffin oil. This treatment mimicked the influence of gonadotropin on both the rate of protein synthesis and the synthesis of specific polypeptides. These findings suggest that gonadotropin-stimulated oocyte growth is attributable largely to the hormone's influence on transfollicular K+ fluxes. They support the hypothesis that the K+ flux and aK changes observed during cell activation are critical in causing subsequent increases in protein synthesis and growth.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Perinuclear localization of Na-K-Cl-cotransporter protein after human cytomegalovirus infection.
L. M. Maglova, W. E. Crowe, and J. M. Russell (2004)
Am J Physiol Cell Physiol 286, C1324-C1334
   Abstract »    Full Text »    PDF »
The Development and Use of a DNA Polymerase Arrest Assay for the Evaluation of Parameters Affecting Intrastrand Tetraplex Formation.
M. N. Weitzmann, K. J. Woodford, and K. Usdin (1996)
J. Biol. Chem. 271, 20958-20964
   Abstract »    Full Text »    PDF »


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