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Science 27 May 1988:
Vol. 240. no. 4856, pp. 1182 - 1185
DOI: 10.1126/science.3375810
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Articles

Science, Vol 240, Issue 4856, 1182-1185
Copyright © 1988 by American Association for the Advancement of Science

articles

Light-addressable potentiometric sensor for biochemical systems

DG Hafeman, JW Parce, and HM McConnell

Molecular Devices Corporation, Palo Alto, CA 94304.

Numerous biochemical reactions can be measured potentiometrically through changes in pH, redox potential, or transmembrane potential. An alternating photocurrent through an electrolyte-insulator-semiconductor interface provides a highly sensitive means to measure such potential changes. A spatially selectable photoresponse permits the determination of a multiplicity of chemical events with a single semiconductor device.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Monitoring of heparin and its low-molecular-weight analogs by silicon field effect.
N. M. Milovic, J. R. Behr, M. Godin, C.-S. J. Hou, K. R. Payer, A. Chandrasekaran, P. R. Russo, R. Sasisekharan, and S. R. Manalis (2006)
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Electronic detection of DNA by its intrinsic molecular charge.
J. Fritz, E. B. Cooper, S. Gaudet, P. K. Sorger, and S. R. Manalis (2002)
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Nanowire Nanosensors for Highly Sensitive and Selective Detection of Biological and Chemical Species.
Y. Cui, Q. Wei, H. Park, and C. M. Lieber (2001)
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The cytosensor microphysiometer: biological applications of silicon technology.
H. McConnell, J. Owicki, J. Parce, D. Miller, G. Baxter, H. Wada, and S Pitchford (1992)
Science 257, 1906-1912
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Detection of cell-affecting agents with a silicon biosensor.
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