Science 27 May 1988: Vol. 240. no. 4856, pp. 1169 - 1176 DOI: 10.1126/science.3131876

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Articles

Mesenchymal Stem Cells Prevent the Rejection of Fully Allogenic Islet Grafts by the Immunosuppressive Activity of Matrix Metalloproteinase-2 and -9.

Y. Ding, D. Xu, G. Feng, A. Bushell, R. J. Muschel, and K. J. Wood (2009)
Diabetes 58, 1797-1806
 |  Abstract »  |  Full Text »  |  PDF »

A brief review of potential mechanisms of immune reconstitution inflammatory syndrome in HIV following antiretroviral therapy.

S Mori and P Levin (2009)
Int J STD AIDS 20, 447-452
 |  Abstract »  |  Full Text »  |  PDF »

The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells.

W. E. O'Gorman, H. Dooms, S. H. Thorne, W. F. Kuswanto, E. F. Simonds, P. O. Krutzik, G. P. Nolan, and A. K. Abbas (2009)
J. Immunol. 183, 332-339
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Cognate CD4 help is essential for the reactivation and expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60.

S. J. Ryu, K. M. Jung, H. S. Yoo, T. W. Kim, S. Kim, J. Chang, and E. Y. Choi (2009)
Blood 113, 4273-4280
 |  Abstract »  |  Full Text »  |  PDF »

Safety and Immunogenicity of a New Tuberculosis Vaccine, MVA85A, in Mycobacterium tuberculosis-infected Individuals.

C. R. Sander, A. A. Pathan, N. E. R. Beveridge, I. Poulton, A. Minassian, N. Alder, J. Van Wijgerden, A. V. S. Hill, F. V. Gleeson, R. J. O. Davies, et al. (2009)
Am. J. Respir. Crit. Care Med. 179, 724-733
 |  Abstract »  |  Full Text »  |  PDF »

Soluble interleukin-2 receptor retains prognostic value in patients with diffuse large B-cell lymphoma receiving rituximab plus CHOP (RCHOP) therapy.

D. Ennishi, M. Yokoyama, Y. Terui, H. Asai, S. Sakajiri, Y. Mishima, S. Takahashi, H. Komatsu, K. Ikeda, K. Takeuchi, et al. (2009)
Ann. Onc. 20, 526-533
 |  Abstract »  |  Full Text »  |  PDF »

Immunotherapy in Patients with Less than Complete Response to Chemotherapy.

F. RECCHIA, G. CANDELORO, S. NECOZIONE, R. BISEGNA, M. BRATTA, and S. REA (2009)
Anticancer Res 29, 567-572
 |  Abstract »  |  Full Text »  |  PDF »

Increased Intratumoral FOXP3-positive Regulatory Immune Cells during Interleukin-2 Treatment in Metastatic Renal Cell Carcinoma.

H. K. Jensen, F. Donskov, M. Nordsmark, N. Marcussen, and H. von der Maase (2009)
Clin. Cancer Res. 15, 1052-1058
 |  Abstract »  |  Full Text »  |  PDF »

The Erk2 MAPK Regulates CD8 T Cell Proliferation and Survival.

W. N. D'Souza, C.-F. Chang, A. M. Fischer, M. Li, and S. M. Hedrick (2008)
J. Immunol. 181, 7617-7629
 |  Abstract »  |  Full Text »  |  PDF »

Age-associated changes in immune and inflammatory responses: impact of vitamin E intervention.

D. Wu and S. N. Meydani (2008)
J. Leukoc. Biol. 84, 900-914
 |  Abstract »  |  Full Text »  |  PDF »

Lung Resident Mesenchymal Stem Cells Isolated from Human Lung Allografts Inhibit T Cell Proliferation via a Soluble Mediator.

L. Jarvinen, L. Badri, S. Wettlaufer, T. Ohtsuka, T. J. Standiford, G. B. Toews, D. J. Pinsky, M. Peters-Golden, and V. N. Lama (2008)
J. Immunol. 181, 4389-4396
 |  Abstract »  |  Full Text »  |  PDF »

Next Generation of Immunotherapy for Melanoma.

J. M. Kirkwood, A. A. Tarhini, M. C. Panelli, S. J. Moschos, H. M. Zarour, L. H. Butterfield, and H. J. Gogas (2008)
J. Clin. Oncol. 26, 3445-3455
 |  Abstract »  |  Full Text »  |  PDF »

Nonoverlapping Expression of IL10, IL12p40, and IFN{gamma} mRNA in the Marginal Zone and T Cell Zone of the Spleen after Antigenic Stimulation.

K. Kalies, P. Konig, Y.-M. Zhang, M. Deierling, J. Barthelmann, C. Stamm, and J. Westermann (2008)
J. Immunol. 180, 5457-5465
 |  Abstract »  |  Full Text »  |  PDF »

STAT5-signaling cytokines regulate the expression of FOXP3 in CD4+CD25+ regulatory T cells and CD4+CD25- effector T cells.

L. Passerini, S. E. Allan, M. Battaglia, S. Di Nunzio, A. N. Alstad, M. K. Levings, M. G. Roncarolo, and R. Bacchetta (2008)
Int. Immunol. 20, 421-431
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Export of NF90 to Stabilize IL-2 mRNA Is Mediated by AKT-Dependent Phosphorylation at Ser647 in Response to CD28 Costimulation.

Y. Pei, P. Zhu, Y. Dang, J. Wu, X. Yang, B. Wan, J. O. Liu, Q. Yi, and L. Yu (2008)
J. Immunol. 180, 222-229
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory T-Cell Markers, Indoleamine 2,3-Dioxygenase, and Virus Levels in Spleen and Gut during Progressive Simian Immunodeficiency Virus Infection.

A. Boasso, M. Vaccari, A. Hryniewicz, D. Fuchs, J. Nacsa, V. Cecchinato, J. Andersson, G. Franchini, G. M. Shearer, and C. Chougnet (2007)
J. Virol. 81, 11593-11603
 |  Abstract »  |  Full Text »  |  PDF »

STAT5 Is Essential for Akt/p70S6 Kinase Activity during IL-2-Induced Lymphocyte Proliferation.

H. M. Lockyer, E. Tran, and B. H. Nelson (2007)
J. Immunol. 179, 5301-5308
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Regulates Expansion of CD4+ T Cell Populations by Affecting Cell Death: Insights from Modeling CFSE Data.

V. V. Ganusov, D. Milutinovic, and R. J. De Boer (2007)
J. Immunol. 179, 950-957
 |  Abstract »  |  Full Text »  |  PDF »

Vaccination regimens incorporating CpG-containing oligodeoxynucleotides and IL-2 generate antigen-specific antitumor immunity from T-cell populations undergoing homeostatic peripheral expansion after BMT.

J. N. Kochenderfer, J. L. Simpson, C. D. Chien, and R. E. Gress (2007)
Blood 110, 450-460
 |  Abstract »  |  Full Text »  |  PDF »

OX40-Mediated Differentiation to Effector Function Requires IL-2 Receptor Signaling but Not CD28, CD40, IL-12Rbeta2, or T-bet.

C. A. Williams, S. E. Murray, A. D. Weinberg, and D. C. Parker (2007)
J. Immunol. 178, 7694-7702
 |  Abstract »  |  Full Text »  |  PDF »

Phase I Trial of BAY 50-4798, an Interleukin-2-Specific Agonist in Advanced Melanoma and Renal Cancer.

K. Margolin, M. B. Atkins, J. P. Dutcher, M. S. Ernstoff, J. W. Smith II, J. I. Clark, J. Baar, J. Sosman, J. Weber, C. Lathia, et al. (2007)
Clin. Cancer Res. 13, 3312-3319
 |  Abstract »  |  Full Text »  |  PDF »

The Virologic, Immunologic, and Clinical Effects of Interleukin 2 With Potent Antiretroviral Therapy in Patients With Moderately Advanced Human Immunodeficiency Virus Infection: A Randomized Controlled Clinical Trial--AIDS Clinical Trials Group 328.

R. Mitsuyasu, R. Gelman, D. W. Cherng, A. Landay, J. Fahey, R. Reichman, A. Erice, R. P. Bucy, J. M. Kilby, M. M. Lederman, et al. (2007)
Arch Intern Med 167, 597-605
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R{alpha}-expressing cells.

H. Dooms, K. Wolslegel, P. Lin, and A. K. Abbas (2007)
J. Exp. Med. 204, 547-557
 |  Abstract »  |  Full Text »  |  PDF »

Selenium Deficiency Induced an Altered Immune Response and Increased Survival Following Influenza A/Puerto Rico/8/34 Infection.

W. Li and M. A. Beck (2007)
Experimental Biology and Medicine 232, 412-419
 |  Abstract »  |  Full Text »  |  PDF »

Antibody-Dependent Cellular Cytotoxicity Mediated by Cetuximab against Lung Cancer Cell Lines.

J. Kurai, H. Chikumi, K. Hashimoto, K. Yamaguchi, A. Yamasaki, T. Sako, H. Touge, H. Makino, M. Takata, M. Miyata, et al. (2007)
Clin. Cancer Res. 13, 1552-1561
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Is Essential for TGF-beta to Convert Naive CD4+CD25- Cells to CD25+Foxp3+ Regulatory T Cells and for Expansion of These Cells.

S. G. Zheng, J. Wang, P. Wang, J. D. Gray, and D. A. Horwitz (2007)
J. Immunol. 178, 2018-2027
 |  Abstract »  |  Full Text »  |  PDF »

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.

A. V. Villarino, C. M. Tato, J. S. Stumhofer, Z. Yao, Y. K. Cui, L. Hennighausen, J. J. O'Shea, and C. A. Hunter (2007)
J. Exp. Med. 204, 65-71
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Synergism between CpG-Containing Oligodeoxynucleotides and IL-2 Causes Dramatic Enhancement of Vaccine-Elicited CD8+ T Cell Responses.

J. N. Kochenderfer, C. D. Chien, J. L. Simpson, and R. E. Gress (2006)
J. Immunol. 177, 8860-8873
 |  Abstract »  |  Full Text »  |  PDF »

Helicobacter pylori VacA Toxin Inhibits Human Immunodeficiency Virus Infection of Primary Human T Cells.

K. Oswald-Richter, V. J. Torres, M. S. Sundrud, S. E. VanCompernolle, T. L. Cover, and D. Unutmaz (2006)
J. Virol. 80, 11767-11775
 |  Abstract »  |  Full Text »  |  PDF »

Control of Memory CD4 T Cell Recall by the CD28/B7 Costimulatory Pathway.

M. P. Ndejembi, J. R. Teijaro, D. S. Patke, A. W. Bingaman, M. R. Chandok, A. Azimzadeh, S. G. Nadler, and D. L. Farber (2006)
J. Immunol. 177, 7698-7706
 |  Abstract »  |  Full Text »  |  PDF »

Lidocaine depresses splenocyte immune functions following trauma-hemorrhage in mice.

T. Kawasaki, M. A. Choudhry, M. G. Schwacha, K. I. Bland, and I. H. Chaudry (2006)
Am J Physiol Cell Physiol 291, C1049-C1055
 |  Abstract »  |  Full Text »  |  PDF »

Phase II Study of Belagenpumatucel-L, a Transforming Growth Factor Beta-2 Antisense Gene-Modified Allogeneic Tumor Cell Vaccine in Non-Small-Cell Lung Cancer.

J. Nemunaitis, R. O. Dillman, P. O. Schwarzenberger, N. Senzer, C. Cunningham, J. Cutler, A. Tong, P. Kumar, B. Pappen, C. Hamilton, et al. (2006)
J. Clin. Oncol. 24, 4721-4730
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Paracrine, but Not Autocrine, IL-2 Signaling Is Sustained during Early Antiviral CD4 T Cell Response.

M. Long and A. J. Adler (2006)
J. Immunol. 177, 4257-4261
 |  Abstract »  |  Full Text »  |  PDF »

In Reply.

F. Donskov and H. von der Maase (2006)
J. Clin. Oncol. 24, 4219-4220
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Human monocyte-derived dendritic cells differentiated in the presence of IL-2 produce proinflammatory cytokines and prime Th1 immune response.

N. Sanarico, A. Ciaramella, A. Sacchi, D. Bernasconi, P. Bossu, F. Mariani, V. Colizzi, and S. Vendetti (2006)
J. Leukoc. Biol. 80, 555-562
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo.

E. Zorn, E. A. Nelson, M. Mohseni, F. Porcheray, H. Kim, D. Litsa, R. Bellucci, E. Raderschall, C. Canning, R. J. Soiffer, et al. (2006)
Blood 108, 1571-1579
 |  Abstract »  |  Full Text »  |  PDF »

Selective Stimulation of T Cell Subsets with Antibody-Cytokine Immune Complexes.

O. Boyman, M. Kovar, M. P. Rubinstein, C. D. Surh, and J. Sprent (2006)
Science 311, 1924-1927
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Crystal structure of the IL-2 signaling complex: Paradigm for a heterotrimeric cytokine receptor.

D. J. Stauber, E. W. Debler, P. A. Horton, K. A. Smith, and I. A. Wilson (2006)
PNAS 103, 2788-2793
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Zones of Lymphoid Organs Constitutively Express Th1 Cytokine mRNA: Specific Changes during the Early Phase of an Immune Response.

K. Kalies, M. Blessenohl, J. Nietsch, and J. Westermann (2006)
J. Immunol. 176, 741-749
 |  Abstract »  |  Full Text »  |  PDF »

IL-27 Limits IL-2 Production during Th1 Differentiation.

A. V. Villarino, J. S. Stumhofer, C. J. M. Saris, R. A. Kastelein, F. J. de Sauvage, and C. A. Hunter (2006)
J. Immunol. 176, 237-247
 |  Abstract »  |  Full Text »  |  PDF »

Structure of the Quaternary Complex of Interleukin-2 with Its {alpha}, {beta}, and {gamma}c Receptors.

X. Wang, M. Rickert, and K. C. Garcia (2005)
Science 310, 1159-1163
 |  Abstract »  |  Full Text »  |  PDF »

Primary Cutaneous T-Cell Lymphomas Show a Deletion or Translocation Affecting NAV3, the Human UNC-53 Homologue.

L. Karenko, S. Hahtola, S. Paivinen, R. Karhu, S. Syrja, M. Kahkonen, B. Nedoszytko, S. Kytola, Y. Zhou, V. Blazevic, et al. (2005)
Cancer Res. 65, 8101-8110
 |  Abstract »  |  Full Text »  |  PDF »

Human High Molecular Weight Melanoma-Associated Antigen Mimicry by Mouse Anti-Idiotypic Monoclonal Antibody MK2-23: Enhancement of Immunogenicity of Anti-Idiotypic Monoclonal Antibody MK2-23 by Fusion with Interleukin 2.

X. Wang, E. C. Ko, L. Peng, S. D. Gillies, and S. Ferrone (2005)
Cancer Res. 65, 6976-6983
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Responsiveness of CD4 and CD8 lymphocytes: further investigations with human IL-2R{beta} transgenic mice.

F. Gesbert, J.-L. Moreau, and J. Theze (2005)
Int. Immunol. 17, 1093-1102
 |  Abstract »  |  Full Text »  |  PDF »

The Structure of Interleukin-2 Complexed with Its Alpha Receptor.

M. Rickert, X. Wang, M. J. Boulanger, N. Goriatcheva, and K. C. Garcia (2005)
Science 308, 1477-1480
 |  Abstract »  |  Full Text »  |  PDF »

Contrasting Effects of Low-Dose IL-2 on Vaccine-Boosted Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cells in Macaques Chronically Infected with SIVmac251.

J. Nacsa, Y. Edghill-Smith, W.-P. Tsai, D. Venzon, E. Tryniszewska, A. Hryniewicz, M. Moniuszko, A. Kinter, K. A. Smith, and G. Franchini (2005)
J. Immunol. 174, 1913-1921
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 and Autocrine IL-4 Drive the In Vivo Development of Antigen-Specific Th2 T Cells Elicited by Nematode Parasites.

Z. Liu, Q. Liu, H. Hamed, R. M. Anthony, A. Foster, F. D. Finkelman, J. F. Urban Jr, and W. C. Gause (2005)
J. Immunol. 174, 2242-2249
 |  Abstract »  |  Full Text »  |  PDF »

Differential regulation of virus-specific T-cell effector functions following activation by peptide or innate cytokines.

C. Beadling and M. K. Slifka (2005)
Blood 105, 1179-1186
 |  Abstract »  |  Full Text »  |  PDF »

Tristetraprolin Down-Regulates IL-2 Gene Expression through AU-Rich Element-Mediated mRNA Decay.

R. L. Ogilvie, M. Abelson, H. H. Hau, I. Vlasova, P. J. Blackshear, and P. R. Bohjanen (2005)
J. Immunol. 174, 953-961
 |  Abstract »  |  Full Text »  |  PDF »

The Yins of T Cell Activation.

J. O. Liu (2005)
Sci. STKE 2005, re1
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2-induced survival of natural killer (NK) cells involving phosphatidylinositol-3 kinase-dependent reduction of ceramide through acid sphingomyelinase, sphingomyelin synthase, and glucosylceramide synthase.

Y. Taguchi, T. Kondo, M. Watanabe, M. Miyaji, H. Umehara, Y. Kozutsumi, and T. Okazaki (2004)
Blood 104, 3285-3293
 |  Abstract »  |  Full Text »  |  PDF »

Cigarette Smoking and Infection.

L. Arcavi and N. L. Benowitz (2004)
Arch Intern Med 164, 2206-2216
 |  Abstract »  |  Full Text »  |  PDF »

IL-15R{alpha} Is a Negative Regulator of TCR-Activated Proliferation in CD4+ T Cells.

J.-M. Lee, C.-Y. Chung, W.-W. Chiang, Y.-H. Liou, C.-F. Chen, and N.-S. Liao (2004)
J. Immunol. 173, 3155-3164
 |  Abstract »  |  Full Text »  |  PDF »

Adenosine Acts through A2 Receptors to Inhibit IL-2-Induced Tyrosine Phosphorylation of STAT5 in T Lymphocytes: Role of Cyclic Adenosine 3',5'-Monophosphate and Phosphatases.

H. Zhang, D. M. Conrad, J. J. Butler, C. Zhao, J. Blay, and D. W. Hoskin (2004)
J. Immunol. 173, 932-944
 |  Abstract »  |  Full Text »  |  PDF »

Nasal Delivery of Antigen with the B Subunit of Escherichia coli Heat-Labile Enterotoxin Augments Antigen-Specific T-Cell Clonal Expansion and Differentiation.

M. Apostolaki and N. A. Williams (2004)
Infect. Immun. 72, 4072-4080
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Induces a Competitive Survival Advantage in T Lymphocytes.

H. Dooms, E. Kahn, B. Knoechel, and A. K. Abbas (2004)
J. Immunol. 172, 5973-5979
 |  Abstract »  |  Full Text »  |  PDF »

Hierarchies in Cytokine Expression Profiles for Acute and Resolving Influenza Virus-Specific CD8+ T Cell Responses: Correlation of Cytokine Profile and TCR Avidity.

N. L. La Gruta, S. J. Turner, and P. C. Doherty (2004)
J. Immunol. 172, 5553-5560
 |  Abstract »  |  Full Text »  |  PDF »

IL-2, Regulatory T Cells, and Tolerance.

B. H. Nelson (2004)
J. Immunol. 172, 3983-3988
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Markers and Physical Performance in Older Persons: The InCHIANTI Study.

M. Cesari, B. W. J. H. Penninx, M. Pahor, F. Lauretani, A. M. Corsi, G. R. Williams, J. M. Guralnik, and L. Ferrucci (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, M242-M248
 |  Abstract »  |  Full Text »  |  PDF »

Disparate In Vitro and In Vivo Requirements for IL-2 During Antigen-Independent CD8 T Cell Expansion.

P. Wong and E. G. Pamer (2004)
J. Immunol. 172, 2171-2176
 |  Abstract »  |  Full Text »  |  PDF »

Theiler's Virus Infection: a Model for Multiple Sclerosis.

E. L. Oleszak, J. R. Chang, H. Friedman, C. D. Katsetos, and C. D. Platsoucas (2004)
Clin. Microbiol. Rev. 17, 174-207
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Is Not Required for the Initiation of CD8 T Cell Cycling but Sustains Expansion.

W. N. D'Souza and L. Lefrancois (2003)
J. Immunol. 171, 5727-5735
 |  Abstract »  |  Full Text »  |  PDF »

Cytokines as Mediators for or Effectors against Rotavirus Disease in Children.

B Jiang, L. Snipes-Magaldi, P. Dennehy, H. Keyserling, R. C. Holman, J. Bresee, J. Gentsch, and R. I. Glass (2003)
Clin. Vaccine Immunol. 10, 995-1001
 |  Abstract »  |  Full Text »  |  PDF »

Suppressor of Cytokine Signaling 3 Regulates Proliferation and Activation of T-helper Cells.

C.-R. Yu, R. M. Mahdi, S. Ebong, B. P. Vistica, I. Gery, and C. E. Egwuagu (2003)
J. Biol. Chem. 278, 29752-29759
 |  Abstract »  |  Full Text »  |  PDF »

Homeostasis of Naive and Memory CD4+ T Cells: IL-2 and IL-7 Differentially Regulate the Balance Between Proliferation and Fas-Mediated Apoptosis.

S. Jaleco, L. Swainson, V. Dardalhon, M. Burjanadze, S. Kinet, and N. Taylor (2003)
J. Immunol. 171, 61-68
 |  Abstract »  |  Full Text »  |  PDF »

Structural Analysis and Modeling of a Synthetic Interleukin-2 Mimetic and Its Interleukin-2R{beta}2 Receptor.

T. Rose, J.-L. Moreau, R. Eckenberg, and J. Theze (2003)
J. Biol. Chem. 278, 22868-22876
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of Adjuvant Efficacy of Herpes Simplex Virus Type 1 Recombinant Viruses Expressing TH1 and TH2 Cytokine Genes.

Y. Osorio and H. Ghiasi (2003)
J. Virol. 77, 5774-5783
 |  Abstract »  |  Full Text »  |  PDF »

CD56bright natural killer cells are present in human lymph nodes and are activated by T cell-derived IL-2: a potential new link between adaptive and innate immunity.

T. A. Fehniger, M. A. Cooper, G. J. Nuovo, M. Cella, F. Facchetti, M. Colonna, and M. A. Caligiuri (2003)
Blood 101, 3052-3057
 |  Abstract »  |  Full Text »  |  PDF »

Loss of the Perforin Cytotoxic Pathway Predisposes Mice to Experimental Cytomegalovirus Retinitis.

R. D. Dix, E. R. Podack, and S. W. Cousins (2003)
J. Virol. 77, 3402-3408
 |  Abstract »  |  Full Text »  |  PDF »

Vaccination of Macaques with Long-Standing SIVmac251 Infection Lowers the Viral Set Point After Cessation of Antiretroviral Therapy.

E. Tryniszewska, J. Nacsa, M. G. Lewis, P. Silvera, D. Montefiori, D. Venzon, Z. Hel, R. W. Parks, M. Moniuszko, J. Tartaglia, et al. (2002)
J. Immunol. 169, 5347-5357
 |  Abstract »  |  Full Text »  |  PDF »

Lymphoadenopathy in IL-2-Deficient Mice: Further Characterization and Overexpression of the Antiapoptotic Molecule Cellular FLIP.

P. Chastagner, J. Reddy, and J. Theze (2002)
J. Immunol. 169, 3644-3651
 |  Abstract »  |  Full Text »  |  PDF »

Opposing Effects of IL-2 in Tumor Immunotherapy: Promoting CD8 T Cell Growth and Inducing Apoptosis.

P. Shrikant and M. F. Mescher (2002)
J. Immunol. 169, 1753-1759
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Interleukin-2 by a Recombinant Herpes Simplex Virus Type 1 Attenuates Pathogenicity and Enhances Antiviral Immunity.

H. Ghiasi, Y. Osorio, G.-C. Perng, A. B. Nesburn, and S. L. Wechsler (2002)
J. Virol. 76, 9069-9078
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the interleukin-2 receptor {alpha} (CD25) is selectively decreased on decidual CD4+ and CD8+ T lymphocytes in normal pregnancies.

K.-H. Chao, M.-Y. Wu, J.-H. Yang, S.-U. Chen, Y.-S. Yang, and H.-N. Ho (2002)
Mol. Hum. Reprod. 8, 667-673
 |  Abstract »  |  Full Text »  |  PDF »

Treatment with Soluble Interleukin-15R{alpha} Exacerbates Intracellular Parasitic Infection by Blocking the Development of Memory CD8+ T Cell Response.

I. A. Khan, M. Moretto, X.-q. Wei, M. Williams, J. D. Schwartzman, and F. Y. Liew (2002)
J. Exp. Med. 195, 1463-1470
 |  Abstract »  |  Full Text »  |  PDF »

Essential Role for IL-2 in the Regulation of Antiviral Extralymphoid CD8 T Cell Responses.

W. N. D'Souza, K. S. Schluns, D. Masopust, and L. Lefrancois (2002)
J. Immunol. 168, 5566-5572
 |  Abstract »  |  Full Text »  |  PDF »

The role of cytokines in classical Hodgkin lymphoma.

B. F. Skinnider and T. W. Mak (2002)
Blood 99, 4283-4297
 |  Abstract »  |  Full Text »  |  PDF »

The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-2.

M. Stahl, P. F. Dijkers, G. J. P. L. Kops, S. M. A. Lens, P. J. Coffer, B. M. T. Burgering, and R. H. Medema (2002)
J. Immunol. 168, 5024-5031
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-2-collagen chimeric protein which liberates interleukin-2 upon collagenolysis.

M. Hayashi, M. Tomita, and K. Yoshizato (2002)
Protein Eng. Des. Sel. 15, 429-436
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Bi-directional modulation of T cell-dependent antibody production by prostaglandin E2.

X. He, C. M. Weyand, J. J. Goronzy, W. Zhong, and J. M. Stuart (2002)
Int. Immunol. 14, 69-77
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Human Glomerulonephritis Accompanied by Active Cellular Infiltrates Shows Effector T Cells in Urine.

M. Sakatsume, Y. Xie, M. Ueno, H. Obayashi, S. Goto, I. Narita, N. Homma, K. Tasaki, Y. Suzuki, and F. Gejyo (2001)
J. Am. Soc. Nephrol. 12, 2636-2644
 |  Abstract »  |  Full Text »  |  PDF »

Donor IFN-{gamma} Receptors Are Critical for Acute CD4+ T Cell-Mediated Cardiac Allograft Rejection.

A. C. Wiseman, B. A. Pietra, B. P. Kelly, G. R. Rayat, M. Rizeq, and R. G. Gill (2001)
J. Immunol. 167, 5457-5463
 |  Abstract »  |  Full Text »  |  PDF »

Low-Avidity Self-Specific T Cells Display a Pronounced Expansion Defect That Can Be Overcome by Altered Peptide Ligands.

K. E. de Visser, T. A. Cordaro, H. W. H. G. Kessels, F. H. Tirion, T. N. M. Schumacher, and A. M. Kruisbeek (2001)
J. Immunol. 167, 3818-3828
 |  Abstract »  |  Full Text »  |  PDF »

Lipoteichoic Acid Inhibits Interleukin-2 (IL-2) Function by Direct Binding to IL-2.

L. M. Plitnick, R. A. Jordan, J. A. Banas, D. M. Jelley-Gibbs, M. C. Walsh, M. T. Preissler, and E. J. Gosselin (2001)
Clin. Vaccine Immunol. 8, 972-979
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of IL-2-Induced T Cell Proliferation and Phosphorylation of STAT3 and STAT5 by Tumor-Derived TGF{{beta}} Is Reversed by IL-15.

J. D. M. Campbell, G. Cook, S. E. Robertson, A. Fraser, K. S. Boyd, J. A. Gracie, and I. M. Franklin (2001)
J. Immunol. 167, 553-561
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Supplementation with {{gamma}}-Linolenic Acid or Fish Oil Decreases T Lymphocyte Proliferation in Healthy Older Humans.

F. Thies, G. Nebe-von-Caron, J. R. Powell, P. Yaqoob, E. A. Newsholme, and P. C. Calder (2001)
J. Nutr. 131, 1918-1927
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Antigen-Independent CD8 T Cell Proliferation.

P. Wong and E. G. Pamer (2001)
J. Immunol. 166, 5864-5868
 |  Abstract »  |  Full Text »  |  PDF »

Phase 1B Study of Subcutaneously Administered Interleukin 2 in Combination with 13-cis Retinoic Acid as Maintenance Therapy in Advanced Cancer.

F. Recchia, S. De Filippis, M. Rosselli, G. Saggio, A. Cesta, L. Fumagalli, and S. Rea (2001)
Clin. Cancer Res. 7, 1251-1257
 |  Abstract »  |  Full Text »

Dietary fatty acids influence the production of Th1- but not Th2-type cytokines.

F. A. Wallace, E. A. Miles, C. Evans, T. E. Stock, P. Yaqoob, and P. C. Calder (2001)
J. Leukoc. Biol. 69, 449-457
 |  Abstract »  |  Full Text »

Receptor Dissociation Constants and the Information Entropy of Membranes Coding Ligand Concentration.

W. M. Getz and P. Lansky (2001)
Chem Senses 26, 95-104
 |  Abstract »  |  Full Text »  |  PDF »

IL-2-induced tumor necrosis factor (TNF)-{beta} expression: further analysis in the IL-2 knockout model, and comparison with TNF-{{alpha}}, lymphotoxin-{beta}, TNFR1 and TNFR2 modulation.

J. Reddy, P. Chastagner, L. Fiette, X. Liu, and J. Theze (2001)
Int. Immunol. 13, 135-147
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Interleukin 15: biology and relevance to human disease.

T. A. Fehniger and M. A. Caligiuri (2001)
Blood 97, 14-32
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The Murine IL-2 Promoter Contains Distal Regulatory Elements Responsive to the Ah Receptor, a Member of the Evolutionarily Conserved bHLH-PAS Transcription Factor Family.

M.-S. Jeon and C. Esser (2000)
J. Immunol. 165, 6975-6983
 |  Abstract »  |  Full Text »  |  PDF »

Lack of CD4+ T Cells Does Not Affect Induction of CD8+ T-Cell Immunity against Encephalitozoon cuniculi Infection.

M. Moretto, L. Casciotti, B. Durell, and I. A. Khan (2000)
Infect. Immun. 68, 6223-6232
 |  Abstract »  |  Full Text »  |  PDF »

Advances in interleukin 2 receptor targeted treatment.

J. C Morris and T. A Waldmann (2000)
Ann Rheum Dis 59, i109-114
 |  Abstract »  |  Full Text »  |  PDF »

IL-2R{beta} Agonist P1-30 Acts in Synergy with IL-2, IL-4, IL-9, and IL-15: Biological and Molecular Effects.

R. Eckenberg, J.-L. Moreau, O. Melnyk, and J. Theze (2000)
J. Immunol. 165, 4312-4318
 |  Abstract »  |  Full Text »  |  PDF »

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