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Science 20 May 1988:
Vol. 240. no. 4855, pp. 1036 - 1038
DOI: 10.1126/science.3285469
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Articles

Science, Vol 240, Issue 4855, 1036-1038
Copyright © 1988 by American Association for the Advancement of Science

articles

Aldolase activity of a Plasmodium falciparum protein with protective properties

U Certa, P Ghersa, H Dobeli, H Matile, HP Kocher, IK Shrivastava, AR Shaw, and LH Perrin

Central Research Units, F. Hoffmann-La Roche and Co., Basel, Switzerland.

Immunization with a 41-kilodalton blood stage antigen (p41) of Plasmodium falciparum induces immunity to malaria in monkeys. However, antigenic polymorphism and repetitive amino acids commonly found in protective antigens complicate vaccine development. The gene encoding p41 has now been cloned and analyzed. Sequencing and hybridization studies revealed that the gene structure is highly conserved in 14 parasite isolates from three continents. This finding and the lack of repetitive amino acids in the translated DNA sequence may indicate that p41 has an essential function. In this study the protein was found to be 60 percent homologous to the key glycolytic enzyme aldolase from vertebrates, and the affinity-purified p41 protein from parasites showed aldolase activity.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
FATAL MALARIA INFECTION IN TRAVELERS: NOVEL IMMUNOHISTOCHEMICAL ASSAYS FOR THE DETECTION OF PLASMODIUM FALCIPARUM IN TISSUES AND IMPLICATIONS FOR PATHOGENESIS.
G. L. GENRICH, J. GUARNER, C. D. PADDOCK, W.-J. SHIEH, P. W. GREER, J. W. BARNWELL, and S. R. ZAKI (2007)
Am J Trop Med Hyg 76, 251-259
   Abstract »    Full Text »    PDF »
Induction of Protective Immune Responses by Immunization with Linear Multiepitope Peptides Based on Conserved Sequences from Plasmodium falciparum Antigens.
A. Bharadwaj, P. Sharma, S. K. Joshi, B. Singh, and V. S. Chauhan (1998)
Infect. Immun. 66, 3232-3241
   Abstract »    Full Text »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)