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Science 20 May 1988:
Vol. 240. no. 4855, pp. 1032 - 1033
DOI: 10.1126/science.3285468
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Articles

Science, Vol 240, Issue 4855, 1032-1033
Copyright © 1988 by American Association for the Advancement of Science

articles

Essential fatty acid depletion of renal allografts and prevention of rejection

GF Schreiner, W Flye, E Brunt, K Korber, and JB Lefkowith

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.

A central hypothesis in transplantation biology is that resident leukocytes expressing class II histocompatibility antigens may determine the immunogenicity of an organ. By means of a novel method to deplete the kidney of resident leukocytes, essential fatty acid deficiency (EFAD), this hypothesis was tested in an intact, vascular organ. Kidneys subjected to EFAD and thus depleted of resident Ia-positive macrophages survived and functioned when transplanted across a major histocompatibility antigen barrier in the absence of immunosuppression of the recipient. Control allografts were rejected promptly. Allografts from donors subjected to EFAD normalized their lipid composition and were repopulated with host macrophages by 5 days. Administration of Ia-positive cells at the time of transplantation established that the resident leukocyte depletion induced by EFAD was responsible for the protective effect. These observations may provide insights into the mechanisms underlying tissue immunogenicity and the population of normal tissues with resident leukocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction of Immunologic Tolerance for Transplantation.
A. A. ROSSINI, D. L. GREINER, and J. P. MORDES (1999)
Physiol Rev 79, 99-141
   Abstract »    Full Text »    PDF »
Effect of a Diet Deficient in Essential Fatty Acids on the Translocation of Intestinal Bacteria.
R. G. Barton, F. B. Cerra, and C. L. Wells (1992)
JPEN J Parenter Enteral Nutr 16, 122-128
   Abstract »    PDF »
Free Radicals, Arachidonic Acid Metabolites, and Nutrition.
M. L. Foegh, G. Thomas, and P. W. Ramwell (1990)
JPEN J Parenter Enteral Nutr 14, 218S-222S
   PDF »
PREVENTING KIDNEY TRANSPLANT REJECTION.
(1988)
Journal Watch (General) 1988, 6
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