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Science 20 May 1988:
Vol. 240. no. 4855, pp. 1026 - 1029
DOI: 10.1126/science.2835813
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Articles

Science, Vol 240, Issue 4855, 1026-1029
Copyright © 1988 by American Association for the Advancement of Science

articles

HIV-1 production from infected peripheral blood T cells after HTLV-I induced mitogenic stimulation

JA Zack, AJ Cann, JP Lugo, and IS Chen

Division of Hematology-Oncology, UCLA School of Medicine 90024.

The human immunodeficiency virus type 1 (HIV-1) and human T-cell leukemia virus type I (HTLV-I) are two distinct human retroviruses that infect T cells. Recent epidemiologic studies have identified a cohort of individuals that are coinfected with both viruses. It is reported here that human peripheral blood leukocytes infected with HIV-1 in vitro can be induced to produce large quantities of HIV-1 after mitogenic stimulation by noninfectious HTLV-I virions. It is also shown that HTLV-I virions may exert this effect prior to, immediately following, or well after the cells are infected with HIV-1. These results provide further impetus for epidemiologic studies of dually infected individuals to determine whether HTLV-I may act as a cofactor for acquired immunodeficiency syndrome (AIDS).


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