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Science 13 May 1988:
Vol. 240. no. 4854, pp. 919 - 922
DOI: 10.1126/science.3363373
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Articles

Science, Vol 240, Issue 4854, 919-922
Copyright © 1988 by American Association for the Advancement of Science

articles

Reduction of naturally occurring motoneuron death in vivo by a target-derived neurotrophic factor

RW Oppenheim, LJ Haverkamp, D Prevette, JL McManaman, and SH Appel

Department of Anatomy, Wake Forest University, Bowman Gray School of Medicine, Winston-Salem, NC 27103.

Treatment of chick embryos in ovo with crude and partially purified extracts from embryonic hindlimbs (days 8 to 9) during the normal cell death period (days 5 to 10) rescues a significant number of motoneurons from degeneration. The survival activity of partially purified extract was dose-dependent and developmentally regulated. The survival of sensory, sympathetic, parasympathetic, and a population of cholinergic sympathetic preganglionic neurons was unaffected by treatment with hindlimb extract. The massive motoneuron death that occurs after early target (hindlimb) removal was partially ameliorated by daily treatment with the hindlimb extract. These results indicate that a target-derived neurotrophic factor is involved in the regulation of motoneuron survival in vivo.


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Astrocyte and Muscle-Derived Secreted Factors Differentially Regulate Motoneuron Survival.
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Cardiotrophin-1, a Muscle-Derived Cytokine, Is Required for the Survival of Subpopulations of Developing Motoneurons.
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Reduction of Neuromuscular Activity Is Required for the Rescue of Motoneurons from Naturally Occurring Cell Death by Nicotinic-Blocking Agents.
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Increased Production of Amyloid Precursor Protein Provides a Substrate for Caspase-3 in Dying Motoneurons.
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Peripheral Target Regulation of the Development and Survival of Spinal Sensory and Motor Neurons in the Chick Embryo.
J. Caldero, D. Prevette, X. Mei, R. A. Oakley, L. Li, C. Milligan, L. Houenou, M. Burek, and R. W. Oppenheim (1998)
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A Novel Type of Programmed Neuronal Death in the Cervical Spinal Cord of the Chick Embryo.
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The expression of trkB and p75 and the role of BDNF in the developing neuromuscular system of the chick embryo.
S. McKay, a Garner, J Caldero, R. Tucker, T Large, and R. Oppenheim (1996)
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Embryonic wing and leg motoneurons have intrinsically different survival properties.
C Mettling, W Camu, and C. Henderson (1993)
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Large-scale normal cell death in the developing rat kidney and its reduction by epidermal growth factor.
H. Coles, J. Burne, and M. Raff (1993)
Development 118, 777-784
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Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor.
R. Oppenheim, D Prevette, Q. Yin, F Collins, and J MacDonald (1991)
Science 251, 1616-1618
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