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Science 13 May 1988:
Vol. 240. no. 4854, pp. 889 - 895
DOI: 10.1126/science.3283939

Articles

Science, Vol 240, Issue 4854, 889-895
Copyright © 1988 by American Association for the Advancement of Science


articles

The steroid and thyroid hormone receptor superfamily

RM Evans

Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, CA 92138-9216.

Analyses of steroid receptors are important for understanding molecular details of transcriptional control, as well as providing insight as to how an individual transacting factor contributes to cell identity and function. These studies have led to the identification of a superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid. Although animals employ complex and often distinct ways to control their physiology and development, the discovery of receptor-related molecules in a wide range of species suggests that mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.


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   Abstract »    Full Text »    PDF »
Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor.
V. Fontaine-Lenoir, B. Chambraud, A. Fellous, S. David, Y. Duchossoy, E.-E. Baulieu, and P. Robel (2006)
PNAS 103, 4711-4716
   Abstract »    Full Text »    PDF »
Gene Expression Analysis of Troglitazone Reveals Its Impact on Multiple Pathways in Cell Culture: A Case for In Vitro Platforms Combined with Gene Expression Analysis for Early (Idiosyncratic) Toxicity Screening.
G. Vansant, P. Pezzoli, R. Saiz, A. Birch, C. Duffy, F. Ferre, and J. Monforte (2006)
International Journal of Toxicology 25, 85-94
   Abstract »    Full Text »    PDF »
Estrogen Receptor (ER) {beta} Modulates ER{alpha}-Mediated Transcriptional Activation by Altering the Recruitment of c-Fos and c-Jun to Estrogen-Responsive Promoters.
J. Matthews, B. Wihlen, M. Tujague, J. Wan, A. Strom, and J.-A. Gustafsson (2006)
Mol. Endocrinol. 20, 534-543
   Abstract »    Full Text »    PDF »
Development of a Panel of Monoclonal Antibodies against the Mineralocorticoid Receptor.
C. E. Gomez-Sanchez, A. F. de Rodriguez, D. G. Romero, J. Estess, M. P. Warden, M. T. Gomez-Sanchez, and E. P. Gomez-Sanchez (2006)
Endocrinology 147, 1343-1348
   Abstract »    Full Text »    PDF »
Heat Shock Protein 90 Is an Essential Molecular Chaperone for Nuclear Transport of Glucocorticoid Receptor {beta}.
X. Zhang, A. F. Clark, and T. Yorio (2006)
Invest. Ophthalmol. Vis. Sci. 47, 700-708
   Abstract »    Full Text »    PDF »
Adverse effects of retinoic acid on embryo development and the selective expression of retinoic acid receptors in mouse blastocysts.
F.-J. Huang, Y.-D. Hsuuw, K.-C. Lan, H.-Y. Kang, S.-Y. Chang, Y.-C. Hsu, and K.-E. Huang (2006)
Hum. Reprod. 21, 202-209
   Abstract »    Full Text »    PDF »
Nuclear Receptor Signaling Atlas (www.nursa.org): hyperlinking the nuclear receptor signaling community.
R. B. Lanz, Z. Jericevic, W. J. Zuercher, C. Watkins, D. L. Steffen, R. Margolis, and N. J. McKenna (2006)
Nucleic Acids Res. 34, D221-D226
   Abstract »    Full Text »    PDF »
From the Cover: Epicardial retinoid X receptor {alpha} is required for myocardial growth and coronary artery formation.
E. Merki, M. Zamora, A. Raya, Y. Kawakami, J. Wang, X. Zhang, J. Burch, S. W. Kubalak, P. Kaliman, J. C. I. Belmonte, et al. (2005)
PNAS 102, 18455-18460
   Abstract »    Full Text »    PDF »
Estrogen receptor-{alpha} mediates gene expression changes and growth response in ovarian cancer cells exposed to estrogen.
A. J M O'Donnell, K. G Macleod, D. J Burns, J. F Smyth, and S. P Langdon (2005)
Endocr. Relat. Cancer 12, 851-866
   Abstract »    Full Text »    PDF »
Regulation of Glucocorticoid Responsiveness in Glaucomatous Trabecular Meshwork Cells by Glucocorticoid Receptor-{beta}.
X. Zhang, A. F. Clark, and T. Yorio (2005)
Invest. Ophthalmol. Vis. Sci. 46, 4607-4616
   Abstract »    Full Text »    PDF »
Rapid Estrogenic Regulation of Extracellular Signal- Regulated Kinase 1/2 Signaling in Cerebellar Granule Cells Involves a G Protein- and Protein Kinase A-Dependent Mechanism and Intracellular Activation of Protein Phosphatase 2A.
S. M. Belcher, H. H. Le, L. Spurling, and J. K. Wong (2005)
Endocrinology 146, 5397-5406
   Abstract »    Full Text »    PDF »
The Growth Hormone Receptor Gene is Associated with Mandibular Height in a Chinese Population.
J. Zhou, Y. Lu, X.H. Gao, Y.C. Chen, J.J. Lu, Y.X. Bai, Y. Shen, and B.K. Wang (2005)
Journal of Dental Research 84, 1052-1056
   Abstract »    Full Text »    PDF »
Glucocorticoid Sensitivity in Young Healthy Individuals: in Vitro and in Vivo Studies.
R. S. Chriguer, L. L. K. Elias, I. M. da Silva Jr., J. G. H. Vieira, A. C. Moreira, and M. de Castro (2005)
J. Clin. Endocrinol. Metab. 90, 5978-5984
   Abstract »    Full Text »    PDF »



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