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Science 29 April 1988:
Vol. 240. no. 4852, pp. 659 - 662
DOI: 10.1126/science.2966437
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Articles

Science, Vol 240, Issue 4852, 659-662
Copyright © 1988 by American Association for the Advancement of Science

articles

Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes

JA Shizuru, C Taylor-Edwards, BA Banks, AK Gregory, and CG Fathman

Department of Medicine, Stanford University Medical Center, CA 94305-5111.

Spontaneous diabetes mellitus was blocked in nonobese diabetic mice by treatment with a monoclonal antibody against the L3T4 determinant present on the surface of T-helper lymphocytes. Sustained treatment with the monoclonal antibody led to cessation of the lymphocytic infiltration associated with the destruction of the insulin-producing beta cells. Moreover, the mice remained normoglycemic after the antibody therapy was stopped. These studies indicate that immunotherapy with monoclonal antibodies to the lymphocyte subset may not only halt the progression of diabetes, but may lead to long-term reversal of the disease after therapy has ended.


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