Science 29 April 1988: Vol. 240. no. 4852, pp. 622 - 630 DOI: 10.1126/science.3283935

Prev | Table of Contents | Next

Articles

ApoE and ApoC-I polymorphisms: association of genotype with cardiovascular disease phenotype in African Americans.

E. Anuurad, M. Yamasaki, N. Shachter, T. A. Pearson, and L. Berglund (2009)
J. Lipid Res. 50, 1472-1478
 |  Abstract »  |  Full Text »  |  PDF »

Discovering New Bioactive Neuropeptides in the Striatum Secretome Using in Vivo Microdialysis and Versatile Proteomics.

B. Bernay, M.-C. Gaillard, V. Guryca, A. Emadali, L. Kuhn, A. Bertrand, I. Detraz, C. Carcenac, M. Savasta, E. Brouillet, et al. (2009)
Mol. Cell. Proteomics 8, 946-958
 |  Abstract »  |  Full Text »  |  PDF »

Genetic influences on blood lipids and cardiovascular disease risk: tools for primary prevention.

J. M Ordovas (2009)
Am. J. Clinical Nutrition 89, 1509S-1517S
 |  Abstract »  |  Full Text »  |  PDF »

Distinct patterns of brain activity in young carriers of the APOE-{varepsilon}4 allele.

N. Filippini, B. J. MacIntosh, M. G. Hough, G. M. Goodwin, G. B. Frisoni, S. M. Smith, P. M. Matthews, C. F. Beckmann, and C. E. Mackay (2009)
PNAS 106, 7209-7214
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond.

A. A. Pendse, J. M. Arbones-Mainar, L. A. Johnson, M. K. Altenburg, and N. Maeda (2009)
J. Lipid Res. 50, S178-S182
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

R. W. Mahley, K. H. Weisgraber, and Y. Huang (2009)
J. Lipid Res. 50, S183-S188
 |  Abstract »  |  Full Text »  |  PDF »

Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure.

N. Zhong and K. H. Weisgraber (2009)
J. Biol. Chem. 284, 6027-6031
 |  Abstract »  |  Full Text »  |  PDF »

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan.

R. W. Halford and D. W. Russell (2009)
PNAS 106, 3502-3506
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E {varepsilon}4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia.

F. Agosta, K. A. Vossel, B. L. Miller, R. Migliaccio, S. J. Bonasera, M. Filippi, A. L. Boxer, A. Karydas, K. L. Possin, and M. L. Gorno-Tempini (2009)
PNAS 106, 2018-2022
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Gene Polymorphism and Gender.

G. Kolovou, D. Damaskos, K. Anagnostopoulou, and D. V. Cokkinos (2009)
Ann. Clin. Lab. Sci. 39, 120-133
 |  Abstract »  |  Full Text »  |  PDF »

Statins are associated with a reduced risk of Alzheimer disease regardless of lipophilicity. The Rotterdam Study.

M D M Haag, A Hofman, P J Koudstaal, B H C Stricker, and M M B Breteler (2009)
J. Neurol. Neurosurg. Psychiatry 80, 13-17
 |  Abstract »  |  Full Text »  |  PDF »

APOE Genotype and Functional Outcome Following Aneurysmal Subarachnoid Hemorrhage.

M. J. Gallek, Y. P. Conley, P. R. Sherwood, M. B. Horowitz, A. Kassam, and S. A. Alexander (2009)
Biol Res Nurs 10, 205-212
 |  Abstract »  |  PDF »

Serum Lipid and Antioxidant Responses in Hypercholesterolemic Men and Women Receiving Plant Sterol Esters Vary by Apolipoprotein E Genotype.

F. J. Sanchez-Muniz, K. C. Maki, E. J. Schaefer, and J. M. Ordovas (2009)
J. Nutr. 139, 13-19
 |  Abstract »  |  Full Text »  |  PDF »

Dendritic Cell Differentiation Induced by a Self-Peptide Derived from Apolipoprotein E.

T. A. Stephens, E. Nikoopour, B. J. Rider, M. Leon-Ponte, T. A. Chau, S. Mikolajczak, P. Chaturvedi, E. Lee-Chan, R. A. Flavell, S. M. M. Haeryfar, et al. (2008)
J. Immunol. 181, 6859-6871
 |  Abstract »  |  Full Text »  |  PDF »

Effective Treatment of Ocular HSK with a Human Apolipoprotein E Mimetic Peptide in a Mouse Eye Model.

P. S. Bhattacharjee, D. M. Neumann, T. P. Foster, C. Clement, G. Singh, H. W. Thompson, H. E. Kaufman, and J. M. Hill (2008)
Invest. Ophthalmol. Vis. Sci. 49, 4263-4268
 |  Abstract »  |  Full Text »  |  PDF »

Brain Apolipoprotein E: an Important Regulator of Food Intake in Rats.

L. Shen, P. Tso, S. C. Woods, D. J. Clegg, K. L. Barber, K. Carey, and M. Liu (2008)
Diabetes 57, 2092-2098
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E-Mediated Immune Regulation in Sepsis.

O. M. Kattan, F. B. Kasravi, E. L. Elford, M. T. Schell, and H. W. Harris (2008)
J. Immunol. 181, 1399-1408
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE {varepsilon}4/{varepsilon}4 genotype accelerates HIV disease progression.

T. D. Burt, B. K. Agan, V. C. Marconi, W. He, H. Kulkarni, J. E. Mold, M. Cavrois, Y. Huang, R. W. Mahley, M. J. Dolan, et al. (2008)
PNAS 105, 8718-8723
 |  Abstract »  |  Full Text »  |  PDF »

Human LDL Receptor Enhances Sequestration of ApoE4 and VLDL Remnants on the Surface of Hepatocytes but Not Their Internalization in Mice.

M. Altenburg, J. Arbones-Mainar, L. Johnson, J. Wilder, and N. Maeda (2008)
Arterioscler. Thromb. Vasc. Biol. 28, 1104-1110
 |  Abstract »  |  Full Text »  |  PDF »

The influence of supplemental lutein and docosahexaenoic acid on serum, lipoproteins, and macular pigmentation.

E. J Johnson, H.-Y. Chung, S. M Caldarella, and D M. Snodderly (2008)
Am. J. Clinical Nutrition 87, 1521-1529
 |  Abstract »  |  Full Text »  |  PDF »

Association between APOE {varepsilon}2/{varepsilon}3/{varepsilon}4 polymorphism and disability severity in a national long-term care survey sample.

A. Kulminski, S. V. Ukraintseva, K. G. Arbeev, K. G. Manton, J. Oshima, G. M. Martin, and A. I. Yashin (2008)
Age Ageing 37, 288-293
 |  Abstract »  |  Full Text »  |  PDF »

Reactivity of Astrocytes to Fibroblast Growth Factor-1 for Biogenesis of Apolipoprotein E-High Density Lipoprotein is Down-regulated by Long-time Secondary Culture.

Y. Nagayasu, J.-i. Ito, T. Nishida, and S. Yokoyama (2008)
J. Biochem. 143, 611-616
 |  Abstract »  |  Full Text »  |  PDF »

Apoetm1Unc mice have impaired alveologenesis, low lung function, and rapid loss of lung function.

D. Massaro and G. D. Massaro (2008)
Am J Physiol Lung Cell Mol Physiol 294, L991-L997
 |  Abstract »  |  Full Text »  |  PDF »

Independent Inhibition of Alzheimer Disease {beta}- and {gamma}-Secretase Cleavage by Lowered Cholesterol Levels.

M. O. W. Grimm, H. S. Grimm, I. Tomic, K. Beyreuther, T. Hartmann, and C. Bergmann (2008)
J. Biol. Chem. 283, 11302-11311
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Gene Polymorphism and Serum Lipid Levels in the Guangxi Hei Yi Zhuang and Han Populations.

R. Yin, S. Pan, J. Wu, W. Lin, and D. Yang (2008)
Experimental Biology and Medicine 233, 409-418
 |  Abstract »  |  Full Text »  |  PDF »

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set.

W. S. Liang, T. Dunckley, T. G. Beach, A. Grover, D. Mastroeni, K. Ramsey, R. J. Caselli, W. A. Kukull, D. McKeel, J. C. Morris, et al. (2008)
Physiol Genomics 33, 240-256
 |  Abstract »  |  Full Text »  |  PDF »

Reduced Apolipoprotein E-Rich High-Density Lipoprotein Level at Birth Is Restored to the Normal Range in Patients with Familial Hypercholesterolemia in the First Year of Life.

H. Nagasaka, T. Miida, K. Hirano, A. Ota, T. Yorifuji, T. Takatani, H. Tsukahara, M. Takayanagi, S.-P. Hui, K. Kobayashi, et al. (2008)
J. Clin. Endocrinol. Metab. 93, 779-783
 |  Abstract »  |  Full Text »  |  PDF »

Intron-3 Retention/Splicing Controls Neuronal Expression of Apolipoprotein E in the CNS.

Q. Xu, D. Walker, A. Bernardo, J. Brodbeck, M. E. Balestra, and Y. Huang (2008)
J. Neurosci. 28, 1452-1459
 |  Abstract »  |  Full Text »  |  PDF »

A novel variant apolipoprotein E Okayama in a patient with lipoprotein glomerulopathy.

M. Kinomura, H. Sugiyama, T. Saito, A. Matsunaga, K.-e. Sada, M. Kanzaki, Y. Takazawa, Y. Maeshima, H. Yanai, and H. Makino (2008)
Nephrol. Dial. Transplant. 23, 751-756
 |  Full Text »  |  PDF »

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.

J. Brodbeck, M. E. Balestra, A. M. Saunders, A. D. Roses, R. W. Mahley, and Y. Huang (2008)
PNAS 105, 1343-1346
 |  Abstract »  |  Full Text »  |  PDF »

Remodeling of apolipoprotein E-containing spherical reconstituted high density lipoproteins by phospholipid transfer protein.

N. Settasatian, P. J. Barter, and K.-A. Rye (2008)
J. Lipid Res. 49, 115-126
 |  Abstract »  |  Full Text »  |  PDF »

Scavenger receptor BI facilitates the metabolism of VLDL lipoproteins in vivo.

M. Van Eck, M. Hoekstra, R. Out, I. S. T. Bos, J. K. Kruijt, R. B. Hildebrand, and T. J. C. Van Berkel (2008)
J. Lipid Res. 49, 136-146
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E polymorphisms, dietary fat and fibre, and serum lipids: the EPIC Norfolk study.

K. Wu, R. Bowman, A. A. Welch, R. N. Luben, N. Wareham, K.-T. Khaw, and S. A. Bingham (2007)
Eur. Heart J. 28, 2930-2936
 |  Abstract »  |  Full Text »  |  PDF »

Profound biopterin oxidation and protein tyrosine nitration in tissues of ApoE-null mice on an atherogenic diet: contribution of inducible nitric oxide synthase.

R. K. Upmacis, M. J. Crabtree, R. S. Deeb, H. Shen, P. B. Lane, L. E. S. Benguigui, N. Maeda, D. P. Hajjar, and S. S. Gross (2007)
Am J Physiol Heart Circ Physiol 293, H2878-H2887
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism?.

S D. Han, A. I Drake, L. M Cessante, A. J Jak, W. S Houston, D. C Delis, J V. Filoteo, and M. W Bondi (2007)
J. Neurol. Neurosurg. Psychiatry 78, 1103-1108
 |  Abstract »  |  Full Text »  |  PDF »

Association of Apolipoprotein E Genotypes With Lipid Levels and Coronary Risk.

A. M. Bennet, E. Di Angelantonio, Z. Ye, F. Wensley, A. Dahlin, A. Ahlbom, B. Keavney, R. Collins, B. Wiman, U. de Faire, et al. (2007)
JAMA 298, 1300-1311
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory region single nucleotide polymorphisms of the apolipoprotein E gene and the rate of cognitive decline in Alzheimer's disease.

O. Belbin, J. L. Dunn, Y. Ling, L. Morgan, S. Chappell, H. Beaumont, D. Warden, D. A. Smith, N. Kalsheker, and K. Morgan (2007)
Hum. Mol. Genet. 16, 2199-2208
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes.

J.-i. Ito, Y. Nagayasu, K. Okumura-Noji, R. Lu, T. Nishida, Y. Miura, K. Asai, A. Kheirollah, S. Nakaya, and S. Yokoyama (2007)
J. Lipid Res. 48, 2020-2027
 |  Abstract »  |  Full Text »  |  PDF »

Meta-analysis of APOE genotype and subarachnoid hemorrhage: Clinical outcome and delayed ischemia.

L. A. Lanterna, Y. Ruigrok, S. Alexander, J. Tang, F. Biroli, L. T. Dunn, and W. S. Poon (2007)
Neurology 69, 766-775
 |  Abstract »  |  Full Text »  |  PDF »

Dissociation of Neuropathologic Findings and Cognition: Case Report of an Apolipoprotein E {varepsilon}2/{varepsilon}2 Genotype.

D. J. Berlau, K. Kahle-Wrobleski, E. Head, M. Goodus, R. Kim, and C. Kawas (2007)
Arch Neurol 64, 1193-1196
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Signaling Pathways Regulating ApoE Gene Expression in Macrophages.

A. V. Gafencu, M. R. Robciuc, E. Fuior, V. I. Zannis, D. Kardassis, and M. Simionescu (2007)
J. Biol. Chem. 282, 21776-21785
 |  Abstract »  |  Full Text »  |  PDF »

Genetic evidence that apolipoprotein E4 is not a relevant susceptibility factor for cholelithiasis in two high-risk populations.

J. G. Mella, R. Schirin-Sokhan, A. Rigotti, F. Pimentel, L. Villarroel, H. E. Wasmuth, T. Sauerbruch, F. Nervi, F. Lammert, and J. F. Miquel (2007)
J. Lipid Res. 48, 1378-1385
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Gene Polymorphisms and Retinal Vascular Signs: The Atherosclerosis Risk in Communities (ARIC) Study.

G. Liew, A. Shankar, J. J. Wang, R. Klein, M. S. Bray, D. J. Couper, A. R. Sharrett, and T. Y. Wong (2007)
Arch Ophthalmol 125, 813-818
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Secretion of Apolipoprotein E2 from Macrophages.

D. Fan, S. Qiu, C. D. Overton, P. G. Yancey, L. L. Swift, W. G. Jerome, M. F. Linton, and S. Fazio (2007)
J. Biol. Chem. 282, 13746-13753
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E4 in Macrophages Enhances Atherogenesis in a Low Density Lipoprotein Receptor-dependent Manner.

M. Altenburg, L. Johnson, J. Wilder, and N. Maeda (2007)
J. Biol. Chem. 282, 7817-7824
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E-Containing Lipoproteins Protect Neurons from Apoptosis via a Signaling Pathway Involving Low-Density Lipoprotein Receptor-Related Protein-1.

H. Hayashi, R. B. Campenot, D. E. Vance, and J. E. Vance (2007)
J. Neurosci. 27, 1933-1941
 |  Abstract »  |  Full Text »  |  PDF »

Survival Related to Plasma C-Reactive-Protein in Nonagenarians Is Modified by Apolipoprotein E Genotype.

T. Lehtimaki, A. Hervonen, R. Rontu, P. Karhunen, M. Jylha, and M. Hurme (2007)
Clin. Chem. 53, 365-367
 |  Full Text »  |  PDF »

Apolipoprotein E Gene and Age-Related Maculopathy in Older Individuals: The Cardiovascular Health Study.

G. Tikellis, C. Sun, M. B. Gorin, R. Klein, B. E. K. Klein, E. K. M. Larsen, D. S. Siscovick, L. D. Hubbard, and T. Y. Wong (2007)
Arch Ophthalmol 125, 68-73
 |  Abstract »  |  Full Text »  |  PDF »

Effects of apolipoprotein E genotype on outcome after ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage.

N A Martinez-Gonzalez and C L M Sudlow (2006)
J. Neurol. Neurosurg. Psychiatry 77, 1329-1335
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein CI stimulates the response to lipopolysaccharide and reduces mortality in Gram-negative sepsis.

J. F. P. Berbee, C. C. van der Hoogt, R. Kleemann, E. F. Schippers, R. L. Kitchens, J. T. van Dissel, I. A. J. M. Bakker-Woudenberg, L. M. Havekes, and P. C. N. Rensen (2006)
FASEB J 20, 2162-2164
 |  Abstract »  |  Full Text »  |  PDF »

Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages..

E. Chertova, O. Chertov, L. V. Coren, J. D. Roser, C. M. Trubey, J. W. Bess Jr., R. C. Sowder II, E. Barsov, B. L. Hood, R. J. Fisher, et al. (2006)
J. Virol. 80, 9039-9052
 |  Abstract »  |  Full Text »  |  PDF »

The effect of apolipoprotein e polymorphism on the response to lipid-lowering treatment with atorvastatin or fenofibrate..

D. S. Christidis, E. N. Liberopoulos, A. I. Kakafika, G. A. Miltiadous, M. Cariolou, E. S. Ganotakis, D. P. Mikhailidis, and M. S. Elisaf (2006)
Journal of Cardiovascular Pharmacology and Therapeutics 11, 211-221
 |  Abstract »  |  PDF »

Advancing the Study of Stroke in Women: Summary and Recommendations for Future Research From an NINDS-Sponsored Multidisciplinary Working Group.

C. D. Bushnell, P. Hurn, C. Colton, V. M. Miller, G. del Zoppo, M. S.V. Elkind, B. Stern, D. Herrington, G. Ford-Lynch, P. Gorelick, et al. (2006)
Stroke 37, 2387-2399
 |  Abstract »  |  Full Text »  |  PDF »

Complete Prevention of Atherosclerosis in ApoE-Deficient Mice by Hepatic Human ApoE Gene Transfer With Adeno-Associated Virus Serotypes 7 and 8.

K. Kitajima, D. H.L. Marchadier, G. C. Miller, G.-p. Gao, J. M. Wilson, and D. J. Rader (2006)
Arterioscler. Thromb. Vasc. Biol. 26, 1852-1857
 |  Abstract »  |  Full Text »  |  PDF »

C-terminal interactions of apolipoprotein E4 respond to the postprandial state.

S. D. Tetali, M. S. Budamagunta, J. C. Voss, and J. C. Rutledge (2006)
J. Lipid Res. 47, 1358-1365
 |  Abstract »  |  Full Text »  |  PDF »

Effect of apolipoprotein e on the cerebral load of latent herpes simplex virus type 1 DNA..

J. S. Burgos, C. Ramirez, I. Sastre, and F. Valdivieso (2006)
J. Virol. 80, 5383-5387
 |  Abstract »  |  Full Text »  |  PDF »

APOE epsilon variation in multiple sclerosis susceptibility and disease severity: Some answers.

R. M. Burwick, P. P. Ramsay, J. L. Haines, S. L. Hauser, J. R. Oksenberg, M. A. Pericak-Vance, S. Schmidt, A. Compston, S. Sawcer, R. Cittadella, et al. (2006)
Neurology 66, 1373-1383
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of reconstituted high density lipoprotein structure and remodeling by apolipoprotein E.

K.-A. Rye, R. Bright, M. Psaltis, and P. J. Barter (2006)
J. Lipid Res. 47, 1025-1036
 |  Abstract »  |  Full Text »  |  PDF »

Alveolar type I cells protect rat lung epithelium from oxidative injury.

J. Chen, Z. Chen, N. R. Chintagari, M. Bhaskaran, N. Jin, T. Narasaraju, and L. Liu (2006)
J. Physiol. 572, 625-638
 |  Abstract »  |  Full Text »  |  PDF »

Inaugural Article: Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

R. W. Mahley, K. H. Weisgraber, and Y. Huang (2006)
PNAS 103, 5644-5651
 |  Abstract »  |  Full Text »  |  PDF »

Profile of Robert W. Mahley.

R. Nuzzo (2006)
PNAS 103, 5641-5643
 |  Full Text »  |  PDF »

Proteomic analysis of nitrated and 4-hydroxy-2-nonenal-modified serum proteins during aging..

C. H. Kim, Y. Zou, D. H. Kim, N. D. Kim, B. P. Yu, and H. Y. Chung (2006)
J. Gerontol. A Biol. Sci. Med. Sci. 61, 332-338
 |  Abstract »  |  Full Text »  |  PDF »

Brain Cholesterol Synthesis in Mice Is Affected by High Dose of Simvastatin but Not of Pravastatin.

K. M. Thelen, K. M. Rentsch, U. Gutteck, M. Heverin, M. Olin, U. Andersson, A. von Eckardstein, I. Bjorkhem, and D. Lutjohann (2006)
J. Pharmacol. Exp. Ther. 316, 1146-1152
 |  Abstract »  |  Full Text »  |  PDF »

Expression of ABCG1, but Not ABCA1, Correlates with Cholesterol Release by Cerebellar Astroglia.

B. Karten, R. B. Campenot, D. E. Vance, and J. E. Vance (2006)
J. Biol. Chem. 281, 4049-4057
 |  Abstract »  |  Full Text »  |  PDF »

Reactivity of Apolipoprotein E4 and Amyloid beta Peptide: LYSOSOMAL STABILITY AND NEURODEGENERATION.

Z.-S. Ji, K. Mullendorff, I. H. Cheng, R. D. Miranda, Y. Huang, and R. W. Mahley (2006)
J. Biol. Chem. 281, 2683-2692
 |  Abstract »  |  Full Text »  |  PDF »

Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy: Structural MR Imaging Changes and Apolipoprotein E Genotype..

R. van den Boom, S.A.J. Lesnick Oberstein, A.A. van den Berg-Huysmans, M.D. Ferrari, M.A. van Buchem, and J. Haan (2006)
AJNR Am. J. Neuroradiol. 27, 359-362
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of regulatory and structural variations in APOE to predicting dyslipidemia.

J. H. Stengard, S. L. R. Kardia, S. C. Hamon, R. Frikke-Schmidt, A. Tybjaerg-Hansen, V. Salomaa, E. Boerwinkle, and C. F. Sing (2006)
J. Lipid Res. 47, 318-328
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E and Alzheimer disease.

Y. Huang (2006)
Neurology 66, S79-S85
 |  Abstract »  |  Full Text »  |  PDF »

Model of Biologically Active Apolipoprotein E Bound to Dipalmitoylphosphatidylcholine.

C. A. Peters-Libeu, Y. Newhouse, D. M. Hatters, and K. H. Weisgraber (2006)
J. Biol. Chem. 281, 1073-1079
 |  Abstract »  |  Full Text »  |  PDF »

Biomarker Discovery from Pancreatic Cancer Secretome Using a Differential Proteomic Approach.

M. Gronborg, T. Z. Kristiansen, A. Iwahori, R. Chang, R. Reddy, N. Sato, H. Molina, O. N. Jensen, R. H. Hruban, M. G. Goggins, et al. (2006)
Mol. Cell. Proteomics 5, 157-171
 |  Abstract »  |  Full Text »  |  PDF »

Inducible Nitric Oxide Synthase Mediates Prostaglandin H2 Synthase Nitration and Suppresses Eicosanoid Production.

R. S. Deeb, H. Shen, C. Gamss, T. Gavrilova, B. D. Summers, R. Kraemer, G. Hao, S. S. Gross, M. Laine, N. Maeda, et al. (2006)
Am. J. Pathol. 168, 349-362
 |  Abstract »  |  Full Text »  |  PDF »

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity.

S. Chang, T. r. Ma, R. D. Miranda, M. E. Balestra, R. W. Mahley, and Y. Huang (2005)
PNAS 102, 18694-18699
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein (apo) E4 enhances amyloid {beta} peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target.

S. Ye, Y. Huang, K. Mullendorff, L. Dong, G. Giedt, E. C. Meng, F. E. Cohen, I. D. Kuntz, K. H. Weisgraber, and R. W. Mahley (2005)
PNAS 102, 18700-18705
 |  Abstract »  |  Full Text »  |  PDF »

Detection of ApoE E2, E3 and E4 alleles using MALDI-TOF mass spectrometry and the homogeneous mass-extend technology.

N. Ghebranious, L. Ivacic, J. Mallum, and C. Dokken (2005)
Nucleic Acids Res. 33, e149
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Genotype in Matched Men and Women with Coronary Heart Disease.

G. D. Kolovou, K. K. Anagnostopoulou, K. D. Salpea, D. B. Panagiotakos, I. S. Hoursalas, M. A. Cariolou, K. Koniavitou, and D. V. Cokkinos (2005)
Ann. Clin. Lab. Sci. 35, 391-396
 |  Abstract »  |  Full Text »  |  PDF »

ATP-Binding Cassette Transporter A1: A Cell Cholesterol Exporter That Protects Against Cardiovascular Disease.

J. F. Oram and J. W. Heinecke (2005)
Physiol Rev 85, 1343-1372
 |  Abstract »  |  Full Text »  |  PDF »

Influence of Atorvastatin on Apolipoprotein E and AI Kinetics in Patients with Type 2 Diabetes.

K. Bach-Ngohou, K. Ouguerram, R. Frenais, P. Maugere, B. Ripolles-Piquer, Y. Zair, M. Krempf, and J. M. Bard (2005)
J. Pharmacol. Exp. Ther. 315, 363-369
 |  Abstract »  |  Full Text »  |  PDF »

Sense and antisense transcripts of the apolipoprotein E gene in normal and ApoE knockout mice, their expression after spinal cord injury and corresponding human transcripts.

A. Seitz, D. Gourevitch, X.-M. Zhang, L. Clark, P. Chen, M. Kragol, N. Levenkova, J. Rux, S. Samulewicz, and E. Heber-Katz (2005)
Hum. Mol. Genet. 14, 2661-2670
 |  Abstract »  |  Full Text »  |  PDF »

USF1 and dyslipidemias: converging evidence for a functional intronic variant.

J. Naukkarinen, M. Gentile, A. Soro-Paavonen, J. Saarela, H. A. Koistinen, P. Pajukanta, M.-R. Taskinen, and L. Peltonen (2005)
Hum. Mol. Genet. 14, 2595-2605
 |  Abstract »  |  Full Text »  |  PDF »

The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.

J. Ruiz, D. Kouiavskaia, M. Migliorini, S. Robinson, E. L. Saenko, N. Gorlatova, D. Li, D. Lawrence, B. T. Hyman, K. H. Weisgraber, et al. (2005)
J. Lipid Res. 46, 1721-1731
 |  Abstract »  |  Full Text »  |  PDF »

apoE4 allele and the natural history of cardiovascular risk factors.

A. Scuteri, S. S. Najjar, D. Muller, R. Andres, C. H. Morrell, A. B. Zonderman, and E. G. Lakatta (2005)
Am J Physiol Endocrinol Metab 289, E322-E327
 |  Abstract »  |  Full Text »  |  PDF »

Candidate gene analysis suggests a role for fatty acid biosynthesis and regulation of the complement system in the etiology of age-related maculopathy.

Y. P. Conley, A. Thalamuthu, J. Jakobsdottir, D. E. Weeks, T. Mah, R. E. Ferrell, and M. B. Gorin (2005)
Hum. Mol. Genet. 14, 1991-2002
 |  Abstract »  |  Full Text »  |  PDF »

Engineering Conformational Destabilization into Mouse Apolipoprotein E: A MODEL FOR A UNIQUE PROPERTY OF HUMAN APOLIPOPROTEIN E4.

D. M. Hatters, C. A. Peters-Libeu, and K. H. Weisgraber (2005)
J. Biol. Chem. 280, 26477-26482
 |  Abstract »  |  Full Text »  |  PDF »

The Low Density Lipoprotein Receptor Regulates the Level of Central Nervous System Human and Murine Apolipoprotein E but Does Not Modify Amyloid Plaque Pathology in PDAPP Mice.

J. D. Fryer, R. B. DeMattos, L. M. McCormick, M. A. O'Dell, M. L. Spinner, K. R. Bales, S. M. Paul, P. M. Sullivan, M. Parsadanian, G. Bu, et al. (2005)
J. Biol. Chem. 280, 25754-25759
 |  Abstract »  |  Full Text »  |  PDF »

Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease?.

J-C Lambert, D Mann, F Richard, J Tian, J Shi, U Thaker, S Merrot, J Harris, B Frigard, T Iwatsubo, et al. (2005)
J. Neurol. Neurosurg. Psychiatry 76, 928-933
 |  Abstract »  |  Full Text »  |  PDF »

Diet-Induced Occlusive Coronary Atherosclerosis, Myocardial Infarction, Cardiac Dysfunction, and Premature Death in Scavenger Receptor Class B Type I-Deficient, Hypomorphic Apolipoprotein ER61 Mice.

S. Zhang, M. H. Picard, E. Vasile, Y. Zhu, R. L. Raffai, K. H. Weisgraber, and M. Krieger (2005)
Circulation 111, 3457-3464
 |  Abstract »  |  Full Text »  |  PDF »

From The Cover: Correlations between apolipoprotein E {epsilon}4 gene dose and brain-imaging measurements of regional hypometabolism.

E. M. Reiman, K. Chen, G. E. Alexander, R. J. Caselli, D. Bandy, D. Osborne, A. M. Saunders, and J. Hardy (2005)
PNAS 102, 8299-8302
 |  Abstract »  |  Full Text »  |  PDF »

Adipocyte Signaling and Lipid Homeostasis: Sequelae of Insulin-Resistant Adipose Tissue.

Y.-H. Yu and H. N. Ginsberg (2005)
Circ. Res. 96, 1042-1052
 |  Abstract »  |  Full Text »  |  PDF »

Screening for Dysbetalipoproteinemia by Plasma Cholesterol and Apolipoprotein B Concentrations.

D. J. Blom, F. H. O'Neill, and A. D. Marais (2005)
Clin. Chem. 51, 904-907
 |  Full Text »  |  PDF »

APOE influences vasospasm and cognition of noncomatose patients with subarachnoid hemorrhage.

L. A. Lanterna, M. Rigoldi, G. Tredici, F. Biroli, C. Cesana, S. M. Gaini, and L. Dalpra (2005)
Neurology 64, 1238-1244
 |  Abstract »  |  Full Text »  |  PDF »

The apolipoprotein CI content of triglyceride-rich lipoproteins independently predicts early atherosclerosis in healthy middle-aged men.

A. Hamsten, A. Silveira, S. Boquist, R. Tang, M. G. Bond, U. de Faire, and J. Bjorkegren (2005)
J. Am. Coll. Cardiol. 45, 1013-1017
 |  Abstract »  |  Full Text »  |  PDF »

Astrocytes produce and secrete FGF-1, which promotes the production of apoE-HDL in a manner of autocrine action.

J.-i. Ito, Y. Nagayasu, R. Lu, A. Kheirollah, M. Hayashi, and S. Yokoyama (2005)
J. Lipid Res. 46, 679-686
 |  Abstract »  |  Full Text »  |  PDF »

Human Apolipoprotein E4 Alters the Amyloid-{beta} 40:42 Ratio and Promotes the Formation of Cerebral Amyloid Angiopathy in an Amyloid Precursor Protein Transgenic Model.

J. D. Fryer, K. Simmons, M. Parsadanian, K. R. Bales, S. M. Paul, P. M. Sullivan, and D. M. Holtzman (2005)
J. Neurosci. 25, 2803-2810
 |  Abstract »  |  Full Text »  |  PDF »

Two-step Mechanism of Binding of Apolipoprotein E to Heparin: IMPLICATIONS FOR THE KINETICS OF APOLIPOPROTEIN E-HEPARAN SULFATE PROTEOGLYCAN COMPLEX FORMATION ON CELL SURFACES.

M. Futamura, P. Dhanasekaran, T. Handa, M. C. Phillips, S. Lund-Katz, and H. Saito (2005)
J. Biol. Chem. 280, 5414-5422
 |  Abstract »  |  Full Text »  |  PDF »

Herpes Simplex Virus Type 1 Infection via the Bloodstream with Apolipoprotein E Dependence in the Gonads Is Influenced by Gender.

J. S. Burgos, C. Ramirez, I. Sastre, J. M. Alfaro, and F. Valdivieso (2005)
J. Virol. 79, 1605-1612
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E and Atherosclerosis: Beyond Lipid Effect.

J. Davignon (2005)
Arterioscler. Thromb. Vasc. Biol. 25, 267-269
 |  Full Text »  |  PDF »

Functional interaction between APOE4 and LDL receptor isoforms in Alzheimer's disease.

D Cheng, R Huang, I S Lanham, H M Cathcart, M Howard, E H Corder, and S E Poduslo (2005)
J. Med. Genet. 42, 129-131
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products