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Science 22 April 1988:
Vol. 240. no. 4851, pp. 524 - 526
DOI: 10.1126/science.3282307
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Articles

Science, Vol 240, Issue 4851, 524-526
Copyright © 1988 by American Association for the Advancement of Science

articles

Independent molecular pathways in initiation and loss of hormone responsiveness of breast carcinomas

S Sukumar, WP Carney, and M Barbacid

Developmental Oncology Section, Basic Research Program, Frederick Cancer Research Facility, MD 21701.

These studies were set up to determine whether those oncogenes participating in the initiation of mammary carcinogenesis (for example, ras oncogenes) play a direct role in the outcome of events associated with the late stages of tumor development such as loss of hormone dependency. Mammary carcinomas induced by a single carcinogenic insult in pubescent rats was selected as an in vivo model system with direct relevance to human breast cancer. Acquisition of hormone-independent growth in these carcinogen-induced tumors was found to be independent of the activation of ras oncogenes during the early stages of carcinogenesis. In agreement with these observations, introduction of a human ras oncogene into human MCF-7 breast carcinoma cells did not abrogate their hormonal dependency for growth in vivo. These findings suggest that those events responsible for the critical stages of breast cancer development occur independently and in an uncoordinated manner.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Estrogen Inducibility of c-Ha-ras Transcription in Breast Cancer Cells. IDENTIFICATION OF FUNCTIONAL ESTROGEN-RESPONSIVE TRANSCRIPTIONAL REGULATORY ELEMENTS IN EXON 1/INTRON 1 OF THE c-Ha-ras GENE.
V. Pethe and P. V. M. Shekhar (1999)
J. Biol. Chem. 274, 30969-30978
   Abstract »    Full Text »    PDF »
Apoptosis and Cell-Cycle Arrest in Human and Murine Tumor Cells Are Initiated by Isoprenoids.
H. Mo and C. E. Elson (1999)
J. Nutr. 129, 804-813
   Abstract »    Full Text »
Activation of ras oncogenes preceding the onset of neoplasia.
R Kumar, S Sukumar, and M Barbacid (1990)
Science 248, 1101-1104
   Abstract »    PDF »


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