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Science 22 April 1988:
Vol. 240. no. 4851, pp. 516 - 518
DOI: 10.1126/science.3128869
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Articles

Science, Vol 240, Issue 4851, 516-518
Copyright © 1988 by American Association for the Advancement of Science

articles

Interferon-gamma: the major mediator of resistance against Toxoplasma gondii

Y Suzuki, MA Orellana, RD Schreiber, and JS Remington

Department of Immunology and Infectious Diseases, Research Institute, Palo Alto Medical Foundation, CA 94301.

Mice were injected with a monoclonal antibody to interferon-gamma to examine the importance of endogenous production of this lymphokine in resistance against infection with the sporozoan parasite Toxoplasma gondii. Mice with intraperitoneal infections of T. gondii that received no antibody survived and developed chronic T. gondii infection, whereas the infected mice that received the monoclonal antibody died of toxoplasmosis. The activation of macrophages, which kill T. gondii in vivo, was inhibited by administration of the monoclonal antibody, but the production of antibodies to T. gondii was not suppressed. The fact that an antibody to interferon-gamma can eliminate resistance to acute Toxoplasma infection in mice suggests that this lymphokine is an important mediator of host resistance to this parasite.


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Infect. Immun. 71, 6615-6619
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Infect. Immun. 71, 2577-2583
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J. Immunol. 167, 4574-4584
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Infect. Immun. 69, 5573-5576
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Involvement of Apoptosis and Interferon-{gamma} in Murine Toxoplasmosis.
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C. Bonenfant, I. Dimier-Poisson, F. Velge-Roussel, D. Buzoni-Gatel, G. Del Giudice, R. Rappuoli, and D. Bout (2001)
Infect. Immun. 69, 1605-1612
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In Vitro Investigation of Host Resistance to Toxoplasma gondii Infection in Microglia of BALB/c and CBA/Ca Mice.
Y. R. Freund, N. T. Zaveri, and H. S. Javitz (2001)
Infect. Immun. 69, 765-772
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Mice Lacking the Chemokine Receptor CCR1 Show Increased Susceptibility to Toxoplasma gondii Infection.
I. A. Khan, P. M. Murphy, L. Casciotti, J. D. Schwartzman, J. Collins, J.-L. Gao, and G. R. Yeaman (2001)
J. Immunol. 166, 1930-1937
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Interleukin-18 (IL-18) Enhances Innate IL-12-Mediated Resistance to Toxoplasma gondii.
G. Cai, R. Kastelein, and C. A. Hunter (2000)
Infect. Immun. 68, 6932-6938
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Identification of STAT4-Dependent and Independent Mechanisms of Resistance to Toxoplasma gondii.
G. Cai, T. Radzanowski, E. N. Villegas, R. Kastelein, and C. A. Hunter (2000)
J. Immunol. 165, 2619-2627
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Recombinant Attenuated Toxoplasma gondii Expressing the Plasmodium yoelii Circumsporozoite Protein Provides Highly Effective Priming for CD8+ T Cell-Dependent Protective Immunity Against Malaria.
H. Charest, M. Sedegah, G. S. Yap, R. T. Gazzinelli, P. Caspar, S. L. Hoffman, and A. Sher (2000)
J. Immunol. 165, 2084-2092
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Differential Infectivity and Division of Toxoplasma gondii in Human Peripheral Blood Leukocytes.
J. Y. Channon, R. M. Seguin, and L. H. Kasper (2000)
Infect. Immun. 68, 4822-4826
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Human Dendritic Cells Discriminate Between Viable and Killed Toxoplasma gondii Tachyzoites: Dendritic Cell Activation After Infection with Viable Parasites Results in CD28 and CD40 Ligand Signaling That Controls IL-12-Dependent and -Independent T Cell Production of IFN-{gamma}.
C. S. Subauste and M. Wessendarp (2000)
J. Immunol. 165, 1498-1505
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IL-10 Is Required for Prevention of Necrosis in the Small Intestine and Mortality in Both Genetically Resistant BALB/c and Susceptible C57BL/6 Mice Following Peroral Infection with Toxoplasma gondii.
Y. Suzuki, A. Sher, G. Yap, D. Park, L. E. Neyer, O. Liesenfeld, M. Fort, H. Kang, and E. Gufwoli (2000)
J. Immunol. 164, 5375-5382
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T Cell Clones Raised from Chronically Infected Healthy Humans by Stimulation with Toxoplasma gondii Excretory-Secretory Antigens Cross-React with Live Tachyzoites: Characterization of the Fine Antigenic Specificity of the Clones and Implications for Vaccine Development.
I. Prigione, P. Facchetti, L. Lecordier, D. Deslee, S. Chiesa, M.-F. Cesbron-Delauw, and V. Pistoia (2000)
J. Immunol. 164, 3741-3748
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B Cells Are Essential for Vaccination-Induced Resistance to Virulent Toxoplasma gondii.
P. C. Sayles, G. W. Gibson, and L. L. Johnson (2000)
Infect. Immun. 68, 1026-1033
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The CD40/CD40 Ligand Interaction Is Required for Resistance to Toxoplasmic Encephalitis.
G. Reichmann, W. Walker, E. N. Villegas, L. Craig, G. Cai, J. Alexander, and C. A. Hunter (2000)
Infect. Immun. 68, 1312-1318
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Decreased Resistance of B Cell-Deficient Mice to Infection with Toxoplasma gondii Despite Unimpaired Expression of IFN-{gamma}, TNF-{alpha}, and Inducible Nitric Oxide Synthase.
H. Kang, J. S. Remington, and Y. Suzuki (2000)
J. Immunol. 164, 2629-2634
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Immune CD8+ T Cells Prevent Reactivation of Toxoplasma gondii Infection in the Immunocompromised Host.
I. A. Khan, W. R. Green, L. H. Kasper, K. A. Green, and J. D. Schwartzman (1999)
Infect. Immun. 67, 5869-5876
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The NF-{kappa}B Family Member RelB Is Required for Innate and Adaptive Immunity to Toxoplasma gondii.
J. Caamano, J. Alexander, L. Craig, R. Bravo, and C. A. Hunter (1999)
J. Immunol. 163, 4453-4461
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IL-15 Prolongs the Duration of CD8+ T Cell-Mediated Immunity in Mice Infected with a Vaccine Strain of Toxoplasma gondii.
I. A. Khan and L. Casciotti (1999)
J. Immunol. 163, 4503-4509
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Role of CD28 in the Generation of Effector and Memory Responses Required for Resistance to Toxoplasma gondii.
E. N. Villegas, M. M. Elloso, G. Reichmann, R. Peach, and C. A. Hunter (1999)
J. Immunol. 163, 3344-3353
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The CD28/B7 Interaction Is Not Required for Resistance to Toxoplasma gondii in the Brain but Contributes to the Development of Immunopathology.
G. Reichmann, E. N. Villegas, L. Craig, R. Peach, and C. A. Hunter (1999)
J. Immunol. 163, 3354-3362
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