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Science 22 April 1988:
Vol. 240. no. 4851, pp. 509 - 511
DOI: 10.1126/science.3282305
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Articles

Science, Vol 240, Issue 4851, 509-511
Copyright © 1988 by American Association for the Advancement of Science

articles

Phosphatidylinositol-glycan anchors of membrane proteins: potential precursors of insulin mediators

G Romero, L Luttrell, A Rogol, K Zeller, E Hewlett, and J Larner

Department of Pharmacology, University of Virginia School of Medicine, Charlottesville 22908.

BC3H1 myocytes release membrane-bound alkaline phosphatase to the incubation medium upon stimulation with insulin, following a time course that is consistent with the generation of dimyristoylglycerol and the appearance of a putative insulin mediator in the extracellular medium. The use of specific blocking agents shows, however, that alkaline phosphatase release and dimyristoylglycerol production are independent processes and that the blockade of either event inhibits the production of insulin mediator. These experiments suggest a new model of insulin action.


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