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Science 18 March 1988:
Vol. 239. no. 4846, pp. 1428 - 1429
DOI: 10.1126/science.2831626
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Articles

Science, Vol 239, Issue 4846, 1428-1429
Copyright © 1988 by American Association for the Advancement of Science

articles

Lithium blocks a phosphoinositide-mediated cholinergic response in hippocampal slices

PF Worley, WA Heller, SH Snyder, and JM Baraban

Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

The effects of lithium on inositol phosphate metabolism may account for the therapeutic actions of lithium in affective disorder. Muscarinic stimulation of the phosphoinositide system blocks synaptic inhibitory actions of adenosine in the hippocampal slice. At therapeutic concentrations, lithium diminished this muscarinic response, whereas rubidium, which does not affect phosphoinositide metabolism, had no effect. A dampening of phosphoinositide-mediated neurotransmission may explain the normalizing effects of lithium in treating both mania and depression.


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The Mechanisms of Action of Lithium: II. Effects on Adenylate Cyclase Activity and {beta}-Adrenergic Receptor Binding in Normal Subjects.
E. D. Risby, J. K. Hsiao, H. K. Manji, J. Bitran, F. Moses, D. F. Zhou, and W. Z. Potter (1991)
Arch Gen Psychiatry 48, 513-524
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