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Science 11 March 1988:
Vol. 239. no. 4845, pp. 1311 - 1313
DOI: 10.1126/science.2964086
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Articles

Science, Vol 239, Issue 4845, 1311-1313
Copyright © 1988 by American Association for the Advancement of Science

articles

Gene encoding the beta subunit of S100 protein is on chromosome 21: implications for Down syndrome

R Allore, D O'Hanlon, R Price, K Neilson, HF Willard, DR Cox, A Marks, and RJ Dunn

Department of Medical Genetics, University of Toronto, Ontario, Canada.

S100 protein is a calcium-binding protein found predominantly in the vertebrate nervous system. Genomic and complementary DNA probes were used in conjunction with a panel of rodent-human somatic cell hybrids to assign the gene for the beta subunit of S100 protein to the distal half of the long arm of human chromosome 21. This gene was identified as a candidate sequence which, when expressed in the trisomic state, may underlie the neurologic disturbances in Down syndrome.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH.
F. Brozzi, C. Arcuri, I. Giambanco, and R. Donato (2009)
J. Biol. Chem. 284, 8797-8811
   Abstract »    Full Text »    PDF »
Genomic and functional profiling of human Down syndrome neural progenitors implicates S100B and aquaporin 4 in cell injury.
G. Esposito, J. Imitola, J. Lu, D. De Filippis, C. Scuderi, V. S. Ganesh, R. Folkerth, J. Hecht, S. Shin, T. Iuvone, et al. (2008)
Hum. Mol. Genet. 17, 440-457
   Abstract »    Full Text »    PDF »
S100B binding to RAGE in microglia stimulates COX-2 expression.
R. Bianchi, C. Adami, I. Giambanco, and R. Donato (2007)
J. Leukoc. Biol. 81, 108-118
   Abstract »    Full Text »    PDF »
Increased expression of calcium-binding protein S100 in human uterine smooth muscle tumours.
T. Kanamori, K. Takakura, M. Mandai, M. Kariya, K. Fukuhara, M. Sakaguchi, N.-h. Huh, K. Saito, T. Sakurai, J. Fujita, et al. (2004)
Mol. Hum. Reprod. 10, 735-742
   Abstract »    Full Text »    PDF »
App Gene Dosage Modulates Endosomal Abnormalities of Alzheimer's Disease in a Segmental Trisomy 16 Mouse Model of Down Syndrome.
A. M. Cataldo, S. Petanceska, C. M. Peterhoff, N. B. Terio, C. J. Epstein, A. Villar, E. J. Carlson, M. Staufenbiel, and R. A. Nixon (2003)
J. Neurosci. 23, 6788-6792
   Abstract »    Full Text »    PDF »
S100B Protein in Biological Fluids: A Tool for Perinatal Medicine.
F. Michetti and D. Gazzolo (2002)
Clin. Chem. 48, 2097-2104
   Abstract »    Full Text »    PDF »
Serum S100 protein as a marker of cerebral damage during cardiac surgery.
M. S. Ali, M. Harmer, and R. Vaughan (2000)
Br. J. Anaesth. 85, 287-298
   Abstract »    Full Text »    PDF »
Distinct subcellular localization of calcium binding S100 proteins in human smooth muscle cells and their relocation in response to rises in intracellular calcium.
A Mandinova, D Atar, B. Schafer, M Spiess, U Aebi, and C. Heizmann (2000)
J. Cell Sci. 111, 2043-2054
   Abstract »    PDF »
Calcium and S100B Regulation of p53-Dependent Cell Growth Arrest and Apoptosis.
C. Scotto, J. C. Deloulme, D. Rousseau, E. Chambaz, and J. Baudier (1998)
Mol. Cell. Biol. 18, 4272-4281
   Abstract »    Full Text »
Cysteine Oxidation in the Mitogenic S100B Protein Leads to Changes in Phosphorylation by Catalytic CKII-alpha Subunit.
C. Scotto, Y. Mely, H. Ohshima, J. Garin, C. Cochet, E. Chambaz, and J. Baudier (1998)
J. Biol. Chem. 273, 3901-3908
   Abstract »    Full Text »    PDF »
S100beta Inhibits alpha 1-Adrenergic Induction of the Hypertrophic Phenotype in Cardiac Myocytes.
J. N. Tsoporis, A. Marks, H. J. Kahn, J. W. Butany, P. P. Liu, D. O'Hanlon, and T. G. Parker (1997)
J. Biol. Chem. 272, 31915-31921
   Abstract »    Full Text »    PDF »
Ca2+-dependent interaction of S100A2 with muscle and nonmuscle tropomyosins.
M Gimona, Z Lando, Y Dolginov, J Vandekerckhove, R Kobayashi, A Sobieszek, and D. Helfman (1997)
J. Cell Sci. 110, 611-621
   Abstract »    PDF »
S100A6 and S100A11 Are Specific Targets of the Calcium- and Zinc-binding S100B Protein in Vivo.
J. C. Deloulme, N. Assard, G. O. Mbele, C. Mangin, R. Kuwano, and J. Baudier (2000)
J. Biol. Chem. 275, 35302-35310
   Abstract »    Full Text »    PDF »
Coregulation of Neurite Outgrowth and Cell Survival by Amphoterin and S100 Proteins through Receptor for Advanced Glycation End Products (RAGE) Activation.
H. J. Huttunen, J. Kuja-Panula, G. Sorci, A. L. Agneletti, R. Donato, and H. Rauvala (2000)
J. Biol. Chem. 275, 40096-40105
   Abstract »    Full Text »    PDF »
The Giant Protein AHNAK Is a Specific Target for the Calcium- and Zinc-binding S100B Protein. POTENTIAL IMPLICATIONS FOR Ca2+ HOMEOSTASIS REGULATION BY S100B.
B. J. Gentil, C. Delphin, G. O. Mbele, J. C. Deloulme, M. Ferro, J. Garin, and J. Baudier (2001)
J. Biol. Chem. 276, 23253-23261
   Abstract »    Full Text »    PDF »


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