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Science 11 March 1988:
Vol. 239. no. 4845, pp. 1302 - 1306
DOI: 10.1126/science.3125612
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Articles

Science, Vol 239, Issue 4845, 1302-1306
Copyright © 1988 by American Association for the Advancement of Science

articles

Regulation of gene expression by interferons: control of H-2 promoter responses

B Korber, N Mermod, L Hood, and I Stroynowski

Division of Biology, California Institute of Technology, Pasadena 91125.

The magnitude of the response to interferons and the requirement for individual elements in the promoter of the H-2Dd gene were shown to be cell-specific and dependent on the type of interferon used. Three DNA sequences in the promoter were found to bind murine nuclear factors. Two of these sequences are in functionally defined enhancer regions and also bind to the transcription factor AP-1. The third sequence is part of the region involved in interferon regulation and is homologous to the enhancer element of the interferon beta gene. A model for interferon regulation of H-2 promoters is discussed.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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A 3'-Transcribed Region of the HLA-A2 Gene Mediates Posttranscriptional Stimulation by IFN-{{gamma}}.
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Independent modes of transcriptional activation by the p50 and p65 subunits of NF-kappa B..
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