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Science 11 March 1988:
Vol. 239. no. 4845, pp. 1296 - 1299
DOI: 10.1126/science.3125611
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Articles

Science, Vol 239, Issue 4845, 1296-1299
Copyright © 1988 by American Association for the Advancement of Science

articles

Dynamic changes in inhibin messenger RNAs in rat ovarian follicles during the reproductive cycle

TK Woodruff, J D'Agostino, NB Schwartz, and KE Mayo

Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208.

The alterations in morphology and function of the ovarian follicle as it matures, ovulates, and becomes a corpus luteum are dramatic. A variety of steroid and polypeptide hormones influence these processes, and the ovary in turn produces specific hormonal signals for endocrine regulation. One such signal is inhibin, a heterodimeric protein that suppresses the secretion of follicle-stimulating hormone from pituitary gonadotrophs. Rat inhibin complementary DNA probes have been used to examine the levels and distribution of inhibin alpha-and beta A-subunit messenger RNAs in the ovaries of cycling animals. Striking, dynamic changes have been found in inhibin messenger RNA accumulation during the developmental maturation of the ovarian follicle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Activin Regulates Estrogen Receptor Gene Expression in the Mouse Ovary.
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Mechanism of Repression of the Inhibin {alpha}-Subunit Gene by Inducible 3',5'-Cyclic Adenosine Monophosphate Early Repressor.
A. D. Burkart, A. Mukherjee, and K. E. Mayo (2006)
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Follicle Size Class Contributes to Distinct Secretion Patterns of Inhibin Isoforms during the Rat Estrous Cycle.
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Enhanced Sexual Behaviors and Androgen Receptor Immunoreactivity in the Male Progesterone Receptor Knockout Mouse.
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Cyclic changes in messenger RNAs encoding inhibin/activin subunits in the ovary of the golden hamster (Mesocricetus auratus).
K. Y Arai, H. Kishi, S. Onodera, W. Jin, G. Watanabe, A. K Suzuki, S. Takahashi, T. Kamada, T. Nishiyama, and K. Taya (2005)
J. Endocrinol. 185, 561-575
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Repression of the Inhibin {alpha}-Subunit Gene by the Transcription Factor CCAAT/Enhancer-Binding Protein-{beta}.
A. D. Burkart, A. Mukherjee, E. Sterneck, P. F. Johnson, and K. E. Mayo (2005)
Endocrinology 146, 1909-1921
   Abstract »    Full Text »    PDF »
Developmental Profiles of Activin {beta}A, {beta}B, and Follistatin Expression in the Zebrafish Ovary: Evidence for Their Differential Roles During Sexual Maturation and Ovulatory Cycle.
Y. Wang and W. Ge (2004)
Biol Reprod 71, 2056-2064
   Abstract »    Full Text »    PDF »
Pregnancy-Associated Plasma Protein-A Production in Rat Granulosa Cells: Stimulation by Follicle-Stimulating Hormone and Inhibition by the Oocyte-Derived Bone Morphogenetic Protein-15.
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Endocrinology 145, 3686-3695
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Influence of mutations affecting gonadotropin production or responsiveness on expression of inhibin subunit mRNA and protein in the mouse ovary.
R. C Hirst, M. H Abel, V. Wilkins, C. Simpson, P. G Knight, F.-P. Zhang, I. Huhtaniemi, T R. Kumar, and H. M Charlton (2004)
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Downregulation of Follicle-Stimulating Hormone (FSH)-Receptor Messenger RNA Levels in the Hamster Ovary: Effect of the Endogenous and Exogenous FSH.
Y.-M. Zhang and S. K. Roy (2004)
Biol Reprod 70, 1580-1588
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Follicle-Restricted Compartmentalization of Transforming Growth Factor {beta} Superfamily Ligands in the Feline Ovary.
S. K. Bristol and T. K. Woodruff (2004)
Biol Reprod 70, 846-859
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Mechanisms of Action of Transforming Growth Factor {beta} on the Expression of Follicle-Stimulating Hormone Receptor Messenger Ribonucleic Acid Levels in Rat Granulosa Cells.
K. Inoue, K. Nakamura, K. Abe, T. Hirakawa, M. Tsuchiya, Y. Oomori, H. Matsuda, K. Miyamoto, and T. Minegishi (2003)
Biol Reprod 69, 1238-1244
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Growth Differentiation Factor-9 Stimulates Inhibin Production and Activates Smad2 in Cultured Rat Granulosa Cells.
J.-S. Roh, J. Bondestam, S. Mazerbourg, N. Kaivo-Oja, N. Groome, O. Ritvos, and A. J. W. Hsueh (2003)
Endocrinology 144, 172-178
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Localization of the Activin Signal Transduction Components in Normal Human Ovarian Follicles: Implications for Autocrine and Paracrine Signaling in the Ovary.
S. A. Pangas, A. W. Rademaker, D. A. Fishman, and T. K. Woodruff (2002)
J. Clin. Endocrinol. Metab. 87, 2644-2657
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Dynamics of Messenger RNAs Encoding Inhibin/Activin Subunits and Follistatin in the Ovary During the Rat Estrous Cycle.
K. Y. Arai, K.-i. Ohshima, G. Watanabe, K. Arai, K. Uehara, and K. Taya (2002)
Biol Reprod 66, 1119-1126
   Abstract »    Full Text »    PDF »
Reproductive Deficiencies in Transgenic Mice Expressing the Rat Inhibin {alpha}-Subunit Gene.
B.-N. Cho, M. L. McMullen, L. Pei, C. J. Yates, and K. E. Mayo (2001)
Endocrinology 142, 4994-5004
   Abstract »    Full Text »    PDF »
Dynamics of Inhibin Subunit and Follistatin mRNA during Development of Normal and Polycystic Ovary Syndrome Follicles.
T. Fujiwara, Y. Sidis, C. Welt, G. Lambert-Messerlian, J. Fox, A. Taylor, and A. Schneyer (2001)
J. Clin. Endocrinol. Metab. 86, 4206-4215
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Developmental Regulation of Mitogen-Activated Protein Kinase-Activated Kinases-2 and -3 (MAPKAPK-2/-3) in Vivo during Corpus Luteum Formation in the Rat.
E. T. Maizels, A. Mukherjee, G. Sithanandam, C. A. Peters, J. Cottom, K. E. Mayo, and M. Hunzicker-Dunn (2001)
Mol. Endocrinol. 15, 716-733
   Abstract »    Full Text »
Modulation of Activin Signal Transduction by Inhibin B and Inhibin-Binding Protein (InhBP).
S. C. Chapman and T. K. Woodruff (2001)
Mol. Endocrinol. 15, 668-679
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The Effect of a Null Mutation in the Follicle-Stimulating Hormone Receptor Gene on Mouse Reproduction.
M. H. Abel, A. N. Wootton, V. Wilkins, I. Huhtaniemi, P. G. Knight, and H. M. Charlton (2000)
Endocrinology 141, 1795-1803
   Abstract »    Full Text »    PDF »
A Role of Insulin-Like Growth Factor I for Follicle-Stimulating Hormone Receptor Expression in Rat Granulosa Cells.
T. Minegishi, T. Hirakawa, H. Kishi, K. Abe, Y. Abe, T. Mizutani, and K. Miyamoto (2000)
Biol Reprod 62, 325-333
   Abstract »    Full Text »
Synergistic Activation of the Inhibin {alpha}-Promoter by Steroidogenic Factor-1 and Cyclic Adenosine 3',5'-Monophosphate.
M. Ito, Y. Park, J. Weck, K. E. Mayo, and J. L. Jameson (2000)
Mol. Endocrinol. 14, 66-81
   Abstract »    Full Text »
Inhibin A and Inhibin B Responses to Gonadotropin Withdrawal Depends on Stage of Follicle Development.
C. K. Welt, J. M. Adams, P. M. Sluss, and J. E. Hall (1999)
J. Clin. Endocrinol. Metab. 84, 2163-2169
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A quantitative sucrose gradient analysis of the translational activity of 18 mRNA species in testes from adult mice.
L. Cataldo, M.-A. Mastrangelo, and K. C. Kleene (1999)
Mol. Hum. Reprod. 5, 206-213
   Abstract »    Full Text »    PDF »
Secretion of Ovarian Inhibin and Its Physiologic Roles in the Regulation of Follicle-Stimulating Hormone Secretion during the Estrous Cycle of the Female Guinea Pig.
F. Shi, M. Ozawa, H. Komura, P. Yang, A. L. Trewin, R. J. Hutz, G. Watanabe, and K. Taya (1999)
Biol Reprod 60, 78-84
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Structure of the Rat Inhibin and Activin {beta}A-Subunit Gene and Regulation in an Ovarian Granulosa Cell Line.
A. M. Ardekani, J. C. D. Romanelli, and K. E. Mayo (1998)
Endocrinology 139, 3271-3279
   Abstract »    Full Text »    PDF »
Gonadotropins Regulate Inducible Cyclic Adenosine 3',5'-Monophosphate Early Repressor in the Rat Ovary: Implications for Inhibin {alpha} Subunit Gene Expression.
A. Mukherjee, J. Urban, P. Sassone-Corsi, and K. E. Mayo (1998)
Mol. Endocrinol. 12, 785-800
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Identification of an Inhibin Receptor in Gonadal Tumors from Inhibin alpha -Subunit Knockout Mice.
L. B. Draper, M. M. Matzuk, V. J. Roberts, E. Cox, J. Weiss, J. P. Mather, and T. K. Woodruff (1998)
J. Biol. Chem. 273, 398-403
   Abstract »    Full Text »    PDF »
Frequency Modulation of Follicle-Stimulating Hormone (FSH) during the Luteal-Follicular Transition: Evidence for FSH Control of Inhibin B in Normal Women.
C. K. Welt, K. A. Martin, A. E. Taylor, G. M. Lambert-Messerlian, W. F. Crowley Jr., J. A. Smith, D. A. Schoenfeld, and J. E. Hall (1997)
J. Clin. Endocrinol. Metab. 82, 2645-2652
   Abstract »    Full Text »    PDF »
Follicle-Stimulating Hormone Induces Terminal Differentiation in a Predifferentiated Rat Granulosa Cell Line (ROG).
R. Li, D. M. Phillips, A. Moore, and J. P. Mather (1997)
Endocrinology 138, 2648-2657
   Abstract »    Full Text »    PDF »


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