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Science 11 March 1988:
Vol. 239. no. 4845, pp. 1269 - 1271
DOI: 10.1126/science.2964085
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Articles

Science, Vol 239, Issue 4845, 1269-1271
Copyright © 1988 by American Association for the Advancement of Science

articles

Structure of the receptor for insulin-like growth factor II: the puzzle amplified

RA Roth

Department of Pharmacology, Stanford University School of Medicine, CA 94305-5332.

The insulin-like growth factor II (IGF-II) is a polypeptide hormone with structural homologies to insulin and insulin-like growth factor I (IGF-I). In contrast to these other hormones, the in vivo function of IGF-II is not known. Although IGF-II can stimulate a broad range of biological responses in isolated cells, these responses have usually been found to be mediated by the insulin and IGF-I receptors. Recently, the receptor for IGF-II was found to also be the receptor for mannose-6-phosphate. Since this latter receptor has been implicated in targeting of lysosomal enzymes, the question is now raised of whether the same protein can also mediate metabolic responses to IGF-II.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Endocrinology 142, 1090-1097
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E. J. Goetzl, H. Dolezalova, Y. Kong, and L. Zeng (1999)
Cancer Res. 59, 4732-4737
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The Insulin-Related Ovarian Regulatory System in Health and Disease.
L. Poretsky, N. A. Cataldo, Z. Rosenwaks, and L. C. Giudice (1999)
Endocr. Rev. 20, 535-582
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Sortilin Is the Major 110-kDa Protein in GLUT4 Vesicles from Adipocytes.
N. J. Morris, S. A. Ross, W. S. Lane, S. K. Moestrup, C. M. Petersen, S. R. Keller, and G. E. Lienhard (1998)
J. Biol. Chem. 273, 3582-3587
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Characterization of Truncated Insulin-Like Growth Factor-Binding Protein-2 in Human Milk.
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Endocrinology 138, 3811-3818
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Functional Epitope Mapping of Insulin-Like Growth Factor I (IGF-I) by Anti-IGF-I Monoclonal Antibodies.
S. Manes, L. Kremer, J. P. Albar, C. Mark, R. Llopis, and C. Martinez-A (1997)
Endocrinology 138, 905-915
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Insulin-like Growth Factor II Induces DNA Synthesis in Fetal Ventricular Myocytes In Vitro.
Q. Liu, H. Yan, N. J. Dawes, G. A. Mottino, J. S. Frank, and H. Zhu (1996)
Circ. Res. 79, 716-726
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In Vivo Coupling of Insulin-like Growth Factor II/Mannose 6-Phosphate Receptor to Heteromeric G Proteins.
T. Ikezu, T. Okamoto, U. Giambarella, T. Yokota, and I. Nishimoto (1995)
J. Biol. Chem. 270, 29224-29228
   Abstract »    Full Text »    PDF »
Insulin-like growth factor II acts through an endogenous growth pathway regulated by imprinting in early mouse embryos..
D A Rappolee, K S Sturm, O Behrendtsen, G A Schultz, R A Pedersen, and Z Werb (1992)
Genes & Dev. 6, 939-952
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Insulin and Insulin-like Growth Factor Receptors and Responses.
R.A. Roth, G. Steele-Perkins, J. Hari, C. Stover, S. Pierce, J. Turner, J.C. Edman, and W.J. Rutter (1988)
Cold Spring Harb Symp Quant Biol 53, 537-543
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Science. ISSN 0036-8075 (print), 1095-9203 (online)