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Science 4 March 1988:
Vol. 239. no. 4844, pp. 1150 - 1153
DOI: 10.1126/science.2964084

Articles

Science, Vol 239, Issue 4844, 1150-1153
Copyright © 1988 by American Association for the Advancement of Science


articles

The Fos complex and Fos-related antigens recognize sequence elements that contain AP-1 binding sites

BR Franza Jr, FJ Rauscher 3rd, SF Josephs, and T Curran

Cold Spring Harbor Laboratory, NY 11724.

The Fos protein complex and several Fos-related antigens bind directly or indirectly to a common sequence element that is similar to the consensus binding site for HeLa cell activator protein 1 (AP-1). This element is present in a negative regulatory sequence in the differentiation-sensitive adipocyte gene, aP2; in a transcriptional enhancer for the Gibbon ape leukemia virus; and in a region of the human immunodeficiency virus (HIV) long terminal repeat partially characterized as a negative regulatory element. The protein level and binding activity of Fos and Fos-related antigens increase rapidly after calcium ionophore treatment of a CD4+ human lymphoblast cell line, H9. These data suggest that several proteins may associate with the AP-1 binding site. Moreover, temporally regulated control of the level of each protein could represent a mechanism for modulation of these putative mediators of gene expression.


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Gene Regulation by Growth Factors.
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Transcriptional Regulation of c-fos.
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Regulation of Proto-oncogene fos: A Paradigm for Early Response Genes.
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Beyond the Second Messenger: Oncogenes and Transcription Factors.
T. Curran, F.J. Rauscher III, D.R. Cohen, and B.R. Franza Jr. (1988)
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Nuclear Oncoproteins Determine the Genetic Program in Response to External Stimuli.
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Identification of Growth-factor-inducible Genes in Mouse Fibroblasts.
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