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Science 4 March 1988:
Vol. 239. no. 4844, pp. 1147 - 1150
DOI: 10.1126/science.2449733
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Articles

Science, Vol 239, Issue 4844, 1147-1150
Copyright © 1988 by American Association for the Advancement of Science

articles

Synaptic reorganization in the hippocampus induced by abnormal functional activity

T Sutula, XX He, J Cavazos, and G Scott

Department of Neurology, University of Wisconsin, Madison 53792.

Abnormal functional activity induces long-lasting physiological alterations in neural pathways that may play a role in the development of epilepsy. The cellular mechanisms of these alterations are not well understood. One hypothesis is that abnormal activity causes structural reorganization of neural pathways and promotes epileptogenesis. This report provides morphological evidence that synchronous perforant path activation and kindling of limbic pathways induce axonal growth and synaptic reorganization in the hippocampus, in the absence of overt morphological damage. The results show a previously unrecognized anatomic plasticity associated with synchronous activity and development of epileptic seizures in neural pathways.


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NMDA Receptor Dependence of Kindling and Mossy Fiber Sprouting: Evidence that the NMDA Receptor Regulates Patterning of Hippocampal Circuits in the Adult Brain.
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Arch Gen Psychiatry 49, 238-243
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