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Science 4 March 1988:
Vol. 239. no. 4844, pp. 1142 - 1145
DOI: 10.1126/science.2449732
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Articles

Science, Vol 239, Issue 4844, 1142-1145
Copyright © 1988 by American Association for the Advancement of Science

articles

Multipotent precursors can give rise to all major cell types of the frog retina

R Wetts and SE Fraser

Department of Physiology and Biophysics, University of California, Irvine 92717.

A prospective lineage analysis was performed to determine the variety of cell types that could be formed by individual precursor cells of the developing frog retina. Fluorescent dextran was iontophoretically injected into single cells of the embryonic optic vesicle. After further development of the embryo, labeled descendants were observed in all three layers of the larval retina. Furthermore, different clones were composed of various combinations of all major cell types, including the glial Muller cells. Hence, single optic vesicle cells have the potential to form any type of retinal cell, suggesting that the interactions that specify the differentiation pathway of retinal cells must occur late in development.


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