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Science 19 February 1988:
Vol. 239. no. 4842, pp. 906 - 910
DOI: 10.1126/science.2893454
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Articles

Science, Vol 239, Issue 4842, 906-910
Copyright © 1988 by American Association for the Advancement of Science

articles

Molecular cloning of a feline leukemia virus that induces fatal immunodeficiency disease in cats

J Overbaugh, PR Donahue, SL Quackenbush, EA Hoover, and JI Mullins

Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115.

A replication-defective variant of feline leukemia virus was molecularly cloned directly from infected tissue and found to induce a rapid and fatal immunodeficiency syndrome in cats. Studies with cloned viruses also showed that subtle mutational changes would convert a minimally pathogenic virus into one that would induce an acute form of immunodeficiency. The data suggest that acutely pathogenic viruses may be selected against by current methods for isolation of the human and simian immunodeficiency viruses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of a Feline Leukemia Virus Variant That Can Use THTR1, FLVCR1, and FLVCR2 for Infection.
Z. Shalev, S. P. Duffy, K. W. Adema, R. Prasad, N. Hussain, B. J. Willett, and C. S. Tailor (2009)
J. Virol. 83, 6706-6716
   Abstract »    Full Text »    PDF »
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro.
P. Cherepanov (2007)
Nucleic Acids Res. 35, 113-124
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Envelope Determinants for Dual-Receptor Specificity in Feline Leukemia Virus Subgroup A and T Variants.
H. H. Cheng, M. M. Anderson, F. C. Hankenson, L. Johnston, C. V. Kotwaliwale, and J. Overbaugh (2006)
J. Virol. 80, 1619-1628
   Abstract »    Full Text »    PDF »
Unique Long Terminal Repeat and Surface Glycoprotein Gene Sequences of Feline Leukemia Virus as Determinants of Disease Outcome.
C. Chandhasin, P. N. Coan, I. Pandrea, C. K. Grant, P. A. Lobelle-Rich, A. Puetter, and L. S. Levy (2005)
J. Virol. 79, 5278-5287
   Abstract »    Full Text »    PDF »
Subtle Mutational Changes in the SU Protein of a Natural Feline Leukemia Virus Subgroup A Isolate Alter Disease Spectrum.
C. Chandhasin, P. N. Coan, and L. S. Levy (2005)
J. Virol. 79, 1351-1360
   Abstract »    Full Text »    PDF »
Porcine Endogenous Retroviruses Infect Cells Lacking Cognate Receptors by an Alternative Pathway: Implications for Retrovirus Evolution and Xenotransplantation.
D. Lavillette and D. Kabat (2004)
J. Virol. 78, 8868-8877
   Abstract »    Full Text »    PDF »
A Virus-Virus Interaction Circumvents the Virus Receptor Requirement for Infection by Pathogenic Retroviruses.
D. L. Wensel, W. Li, and J. M. Cunningham (2003)
J. Virol. 77, 3460-3469
   Abstract »    Full Text »    PDF »
Structure and Mechanism of a Coreceptor for Infection by a Pathogenic Feline Retrovirus.
A. L. Barnett, D. L. Wensel, W. Li, D. Fass, and J. M. Cunningham (2003)
J. Virol. 77, 2717-2729
   Abstract »    Full Text »    PDF »
Host Range and Receptor Binding Properties of Vectors Bearing Feline Leukemia Virus Subgroup B Envelopes Can Be Modulated by Envelope Sequences outside of the Receptor Binding Domain.
P. H. Faix, S. A. Feldman, J. Overbaugh, and M. V. Eiden (2002)
J. Virol. 76, 12369-12375
   Abstract »    Full Text »    PDF »
Genetic and Biochemical Analyses of Receptor and Cofactor Determinants for T-Cell-Tropic Feline Leukemia Virus Infection.
A. S. Lauring, H. H. Cheng, M. V. Eiden, and J. Overbaugh (2002)
J. Virol. 76, 8069-8078
   Abstract »    Full Text »    PDF »
Feline Pit2 Functions as a Receptor for Subgroup B Feline Leukemia Viruses.
M. M. Anderson, A. S. Lauring, S. Robertson, C. Dirks, and J. Overbaugh (2001)
J. Virol. 75, 10563-10572
   Abstract »    Full Text »    PDF »
Specificity in Receptor Usage by T-Cell-Tropic Feline Leukemia Viruses: Implications for the In Vivo Tropism of Immunodeficiency-Inducing Variants.
A. S. Lauring, M. M. Anderson, and J. Overbaugh (2001)
J. Virol. 75, 8888-8898
   Abstract »    Full Text »    PDF »
Receptor Binding Transforms the Surface Subunit of the Mammalian C-Type Retrovirus Envelope Protein from an Inhibitor to an Activator of Fusion.
A. L. Barnett and J. M. Cunningham (2001)
J. Virol. 75, 9096-9105
   Abstract »    Full Text »    PDF »
Selection Forces and Constraints on Retroviral Sequence Variation.
J. Overbaugh and C. R. M. Bangham (2001)
Science 292, 1106-1109
   Abstract »    Full Text »
Feline Leukemia Virus Envelope Sequences That Affect T-Cell Tropism and Syncytium Formation Are Not Part of Known Receptor-Binding Domains.
S. R. Gwynn, F. C. Hankenson, A. S. Lauring, J. L. Rohn, and J. Overbaugh (2000)
J. Virol. 74, 5754-5761
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Differential Pathogenicity of Two Feline Leukemia Virus Subgroup A Molecular Clones, pFRA and pF6A.
A. J. Phipps, H. Chen, K. A. Hayes, P. Roy-Burman, and L. E. Mathes (2000)
J. Virol. 74, 5796-5801
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Identification of a Cellular Cofactor Required for Infection by Feline Leukemia Virus.
M. M. Anderson, A. S. Lauring, C. C. Burns, and J. Overbaugh (2000)
Science 287, 1828-1830
   Abstract »    Full Text »
Expression of Viral Proteins in Feline Leukemia Virus-associated Enteritis.
A. Kipar, J. Kremendahl, C. K. Grant, I. von Bothmer, and M. Reinacher (2000)
Vet. Pathol. 37, 129-136
   Abstract »    Full Text »    PDF »
A Putative Cell Surface Receptor for Anemia-Inducing Feline Leukemia Virus Subgroup C Is a Member of a Transporter Superfamily.
C. S. Tailor, B. J. Willett, and D. Kabat (1999)
J. Virol. 73, 6500-6505
   Abstract »    Full Text »
Feline Leukemia Virus Long Terminal Repeat Activates Collagenase IV Gene Expression through AP-1.
S. K. Ghosh and D. V. Faller (1999)
J. Virol. 73, 4931-4940
   Abstract »    Full Text »
Pathogenicity Induced by Feline Leukemia Virus, Rickard Strain, Subgroup A Plasmid DNA (pFRA).
H. Chen, M. K. Bechtel, Y. Shi, A. Phipps, L. E. Mathes, K. A. Hayes, and P. Roy-Burman (1998)
J. Virol. 72, 7048-7056
   Abstract »    Full Text »    PDF »
In Vivo Evolution of a Novel, Syncytium-Inducing and Cytopathic Feline Leukemia Virus Variant.
J. L. Rohn, M. S. Moser, S. R. Gwynn, D. N. Baldwin, and J. Overbaugh (1998)
J. Virol. 72, 2686-2696
   Abstract »    Full Text »    PDF »
Evolution of a Simian Immunodeficiency Virus Pathogen.
P. Edmonson, M. Murphey-Corb, L. N. Martin, C. Delahunty, J. Heeney, H. Kornfeld, P. R. Donahue, G. H. Learn, L. Hood, and J. I. Mullins (1998)
J. Virol. 72, 405-414
   Abstract »    Full Text »    PDF »
High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.
M Piatak Jr, M. Saag, L. Yang, S. Clark, J. Kappes, K. Luk, B. Hahn, G. Shaw, and J. Lifson (1993)
Science 259, 1749-1754
   Abstract »    PDF »
Amplimers with 3'-terminal phosphorothioate linkages resist degradation by vent polymerase and reduce Taq polymerase mispriming..
C M de Noronha and J I Mullins (1992)
Genome Res. 2, 131-136
   Abstract »    PDF »
West African HIV-2-related human retrovirus with attenuated cytopathicity.
L. Kong, S. Lee, J. Kappes, J. Parkin, D Decker, J. Hoxie, B. Hahn, and G. Shaw (1988)
Science 240, 1525-1529
   Abstract »    PDF »


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