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Science 19 February 1988:
Vol. 239. no. 4842, pp. 906 - 910
DOI: 10.1126/science.2893454
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Articles

Science, Vol 239, Issue 4842, 906-910
Copyright © 1988 by American Association for the Advancement of Science

articles

Molecular cloning of a feline leukemia virus that induces fatal immunodeficiency disease in cats

J Overbaugh, PR Donahue, SL Quackenbush, EA Hoover, and JI Mullins

Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115.

A replication-defective variant of feline leukemia virus was molecularly cloned directly from infected tissue and found to induce a rapid and fatal immunodeficiency syndrome in cats. Studies with cloned viruses also showed that subtle mutational changes would convert a minimally pathogenic virus into one that would induce an acute form of immunodeficiency. The data suggest that acutely pathogenic viruses may be selected against by current methods for isolation of the human and simian immunodeficiency viruses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Z. Shalev, S. P. Duffy, K. W. Adema, R. Prasad, N. Hussain, B. J. Willett, and C. S. Tailor (2009)
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LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro.
P. Cherepanov (2007)
Nucleic Acids Res. 35, 113-124
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Envelope Determinants for Dual-Receptor Specificity in Feline Leukemia Virus Subgroup A and T Variants.
H. H. Cheng, M. M. Anderson, F. C. Hankenson, L. Johnston, C. V. Kotwaliwale, and J. Overbaugh (2006)
J. Virol. 80, 1619-1628
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Unique Long Terminal Repeat and Surface Glycoprotein Gene Sequences of Feline Leukemia Virus as Determinants of Disease Outcome.
C. Chandhasin, P. N. Coan, I. Pandrea, C. K. Grant, P. A. Lobelle-Rich, A. Puetter, and L. S. Levy (2005)
J. Virol. 79, 5278-5287
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Subtle Mutational Changes in the SU Protein of a Natural Feline Leukemia Virus Subgroup A Isolate Alter Disease Spectrum.
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Porcine Endogenous Retroviruses Infect Cells Lacking Cognate Receptors by an Alternative Pathway: Implications for Retrovirus Evolution and Xenotransplantation.
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A Virus-Virus Interaction Circumvents the Virus Receptor Requirement for Infection by Pathogenic Retroviruses.
D. L. Wensel, W. Li, and J. M. Cunningham (2003)
J. Virol. 77, 3460-3469
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Structure and Mechanism of a Coreceptor for Infection by a Pathogenic Feline Retrovirus.
A. L. Barnett, D. L. Wensel, W. Li, D. Fass, and J. M. Cunningham (2003)
J. Virol. 77, 2717-2729
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Host Range and Receptor Binding Properties of Vectors Bearing Feline Leukemia Virus Subgroup B Envelopes Can Be Modulated by Envelope Sequences outside of the Receptor Binding Domain.
P. H. Faix, S. A. Feldman, J. Overbaugh, and M. V. Eiden (2002)
J. Virol. 76, 12369-12375
   Abstract »    Full Text »    PDF »
Genetic and Biochemical Analyses of Receptor and Cofactor Determinants for T-Cell-Tropic Feline Leukemia Virus Infection.
A. S. Lauring, H. H. Cheng, M. V. Eiden, and J. Overbaugh (2002)
J. Virol. 76, 8069-8078
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Feline Pit2 Functions as a Receptor for Subgroup B Feline Leukemia Viruses.
M. M. Anderson, A. S. Lauring, S. Robertson, C. Dirks, and J. Overbaugh (2001)
J. Virol. 75, 10563-10572
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Specificity in Receptor Usage by T-Cell-Tropic Feline Leukemia Viruses: Implications for the In Vivo Tropism of Immunodeficiency-Inducing Variants.
A. S. Lauring, M. M. Anderson, and J. Overbaugh (2001)
J. Virol. 75, 8888-8898
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Receptor Binding Transforms the Surface Subunit of the Mammalian C-Type Retrovirus Envelope Protein from an Inhibitor to an Activator of Fusion.
A. L. Barnett and J. M. Cunningham (2001)
J. Virol. 75, 9096-9105
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Selection Forces and Constraints on Retroviral Sequence Variation.
J. Overbaugh and C. R. M. Bangham (2001)
Science 292, 1106-1109
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Feline Leukemia Virus Envelope Sequences That Affect T-Cell Tropism and Syncytium Formation Are Not Part of Known Receptor-Binding Domains.
S. R. Gwynn, F. C. Hankenson, A. S. Lauring, J. L. Rohn, and J. Overbaugh (2000)
J. Virol. 74, 5754-5761
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Differential Pathogenicity of Two Feline Leukemia Virus Subgroup A Molecular Clones, pFRA and pF6A.
A. J. Phipps, H. Chen, K. A. Hayes, P. Roy-Burman, and L. E. Mathes (2000)
J. Virol. 74, 5796-5801
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Identification of a Cellular Cofactor Required for Infection by Feline Leukemia Virus.
M. M. Anderson, A. S. Lauring, C. C. Burns, and J. Overbaugh (2000)
Science 287, 1828-1830
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Expression of Viral Proteins in Feline Leukemia Virus-associated Enteritis.
A. Kipar, J. Kremendahl, C. K. Grant, I. von Bothmer, and M. Reinacher (2000)
Vet. Pathol. 37, 129-136
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A Putative Cell Surface Receptor for Anemia-Inducing Feline Leukemia Virus Subgroup C Is a Member of a Transporter Superfamily.
C. S. Tailor, B. J. Willett, and D. Kabat (1999)
J. Virol. 73, 6500-6505
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Feline Leukemia Virus Long Terminal Repeat Activates Collagenase IV Gene Expression through AP-1.
S. K. Ghosh and D. V. Faller (1999)
J. Virol. 73, 4931-4940
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Pathogenicity Induced by Feline Leukemia Virus, Rickard Strain, Subgroup A Plasmid DNA (pFRA).
H. Chen, M. K. Bechtel, Y. Shi, A. Phipps, L. E. Mathes, K. A. Hayes, and P. Roy-Burman (1998)
J. Virol. 72, 7048-7056
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In Vivo Evolution of a Novel, Syncytium-Inducing and Cytopathic Feline Leukemia Virus Variant.
J. L. Rohn, M. S. Moser, S. R. Gwynn, D. N. Baldwin, and J. Overbaugh (1998)
J. Virol. 72, 2686-2696
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Evolution of a Simian Immunodeficiency Virus Pathogen.
P. Edmonson, M. Murphey-Corb, L. N. Martin, C. Delahunty, J. Heeney, H. Kornfeld, P. R. Donahue, G. H. Learn, L. Hood, and J. I. Mullins (1998)
J. Virol. 72, 405-414
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High levels of HIV-1 in plasma during all stages of infection determined by competitive PCR.
M Piatak Jr, M. Saag, L. Yang, S. Clark, J. Kappes, K. Luk, B. Hahn, G. Shaw, and J. Lifson (1993)
Science 259, 1749-1754
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Amplimers with 3'-terminal phosphorothioate linkages resist degradation by vent polymerase and reduce Taq polymerase mispriming..
C M de Noronha and J I Mullins (1992)
Genome Res. 2, 131-136
   Abstract »    PDF »
West African HIV-2-related human retrovirus with attenuated cytopathicity.
L. Kong, S. Lee, J. Kappes, J. Parkin, D Decker, J. Hoxie, B. Hahn, and G. Shaw (1988)
Science 240, 1525-1529
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