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Science 12 February 1988:
Vol. 239. no. 4841, pp. 786 - 788
DOI: 10.1126/science.3257586
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Articles

Science, Vol 239, Issue 4841, 786-788
Copyright © 1988 by American Association for the Advancement of Science

articles

One factor recognizes the liver-specific enhancers in alpha 1-antitrypsin and transthyretin genes

DR Grayson, RH Costa, KG Xanthopoulos, and JE Darnell

Rockefeller University, New York, NY 10021.

Four different regulatory sites required for transcriptional stimulation by the enhancers of two unrelated liver-specific genes alpha 1-antitrypsin and transthyretin appear to bind the same nuclear protein that is found mainly in the liver. Such proteins may provide a basis for a coordinated, hepatocyte-specific control of gene transcription.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Association between Hepatocyte Nuclear Factor 6 (HNF-6) and FoxA2 DNA Binding Domains Stimulates FoxA2 Transcriptional Activity but Inhibits HNF-6 DNA Binding.
F. M. Rausa, Y. Tan, and R. H. Costa (2003)
Mol. Cell. Biol. 23, 437-449
   Abstract »    Full Text »    PDF »
Increased Hepatic Cell Proliferation and Lung Abnormalities in Mice Deficient in CCAAT/Enhancer Binding Protein alpha.
P. Flodby, C. Barlow, H. Kylefjord, L. Ahrlund-Richter, and K. G. Xanthopoulos (1996)
J. Biol. Chem. 271, 24753-24760
   Abstract »    Full Text »    PDF »
Postnatal repression of the alpha-fetoprotein gene is enhancer independent..
S A Camper and S M Tilghman (1989)
Genes & Dev. 3, 537-546
   Abstract »    PDF »


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