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Science 5 February 1988:
Vol. 239. no. 4840, pp. 643 - 645
DOI: 10.1126/science.3340848
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Articles

Science, Vol 239, Issue 4840, 643-645
Copyright © 1988 by American Association for the Advancement of Science

articles

Cell-cell interactions in the guidance of late-developing neurons in Caenorhabditis elegans

WW Walthall and M Chalfie

Department of Biological Sciences, Columbia University, New York, NY 10027.

The initial outgrowth of developing neuronal processes can be affected by a number of extrinsic interactions. Cell-cell interactions are also important in a later stage of neuronal outgrowth when processes grow into the region of their targets. The correct positioning of the process of a postembryonic sensory neuron, the touch cell AVM of the nematode Caenorhabditis elegans, at its synaptic targets requires the presence of a pair of embryonic interneurons, the BDU cells. These cells receive synapses from AVM but do not participate in the touch reflex circuit. Therefore, the AVM-BDU synapses may be required to stabilize the association between these cells and assist in the guidance of the AVM processes through a mature neuropil.


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UNC-55, an Orphan Nuclear Hormone Receptor, Orchestrates Synaptic Specificity among Two Classes of Motor Neurons in Caenorhabditis elegans.
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Green fluorescent protein as a marker for gene expression.
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Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans.
S Mitani, H Du, D. Hall, M Driscoll, and M Chalfie (1993)
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Cell interactions control the direction of outgrowth, branching and fasciculation of the HSN axons of Caenorhabditis elegans.
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Genetic control of differentiation of the Caenorhabditis elegans touch receptor neurons.
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The nematode Caenorhabditis elegans.
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Science. ISSN 0036-8075 (print), 1095-9203 (online)