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Science 5 February 1988:
Vol. 239. no. 4840, pp. 617 - 622
DOI: 10.1126/science.3277274

Articles

Science, Vol 239, Issue 4840, 617-622
Copyright © 1988 by American Association for the Advancement of Science


articles

The human immunodeficiency virus: infectivity and mechanisms of pathogenesis

AS Fauci

National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.

Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects. HIV can exist in a latent or chronic form which can be converted to a productive infection by a variety of inductive signals.


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Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells.
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Arch Gen Psychiatry 48, 171-177
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The effect of anti-neoplastic drugs on murine acquired immunodeficiency syndrome.
C Simard and P Jolicoeur (1991)
Science 251, 305-308
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Reactive Oxygen Species, Antioxidants, and Acquired Immunodeficiency Syndrome: Sense or Speculation?.
B. Halliwell and C. E. Cross (1991)
Arch Intern Med 151, 29-31
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Increasing Viral Burden in CD4+ T Cells from Patients with Human Immunodeficiency Virus (HIV) Infection Reflects Rapidly Progressive Immunosuppression and Clinical Disease.
S. M. Schnittman, J. J. Greenhouse, M. C. Psallidopoulos, M. Baseler, N. P. Salzman, A. S. Fauci, and H. C. Lane (1990)
Ann Intern Med 113, 438-443
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Benign Nasopharyngeal Masses and Human Immunodeficiency Virus Infection.
J. C. Stern, P.-T. Lin, and F. E. Lucente (1990)
Arch Otolaryngol Head Neck Surg 116, 206-208
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Inhibition of antigen-induced lymphocyte proliferation by Tat protein from HIV-1.
R. Viscidi, K Mayur, H. Lederman, and A. Frankel (1989)
Science 246, 1606-1608
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Immunodeficiency and clonal growth of target cells induced by helper-free defective retrovirus.
M Huang, C Simard, and P Jolicoeur (1989)
Science 246, 1614-1617
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Functional analysis of CAR, the target sequence for the Rev protein of HIV-1.
E. Dayton, D. Powell, and A. Dayton (1989)
Science 246, 1625-1629
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Co-infection with Human Immunodeficiency Virus-Type 1 (HIV-1) and Cytomegalovirus in Two Intravenous Drug Users.
A. Bonetti, R. Weber, M. W. Vogt, W. Wunderli, W. Siegenthaler, and R. Luthy (1989)
Ann Intern Med 111, 293-296
   Abstract »    PDF »
The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4.
S. Schnittman, M. Psallidopoulos, H. Lane, L Thompson, M Baseler, F Massari, C. Fox, N. Salzman, and A. Fauci (1989)
Science 245, 305-308
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Zidovudine in Patients with Human Immunodeficiency Virus (HIV) Infection and Kaposi Sarcoma: A Phase II Randomized, Placebo-Controlled Trial.
H. C. Lane, J. Falloon, R. E. Walker, L. Deyton, J. A. Kovacs, H. Masur, S. Banks, L. E. Kirk, M. W. Baseler, N. P. Salzman, et al. (1989)
Ann Intern Med 111, 41-50
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Predictive Markers for the Acquired Immunodeficiency Syndrome (AIDS) in Hemophiliacs: Persistence of p24 Antigen and Low T4 Cell Count.
M. E. Eyster, J. O. Ballard, M. H. Gail, J. E. Drammond, and J. J. Goedert (1989)
Ann Intern Med 110, 963-969
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Involvement of a leukocyte adhesion receptor (LFA-1) in HIV-induced syncytium formation.
J. Hildreth and R. Orentas (1989)
Science 244, 1075-1078
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