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Science 5 February 1988: Vol. 239. no. 4840, pp. 617 - 622 DOI: 10.1126/science.3277274
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Articles
Science, Vol 239, Issue 4840, 617-622
Copyright © 1988 by American Association for the Advancement of Science
The human immunodeficiency virus: infectivity and mechanisms of pathogenesis
AS Fauci
National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
Infection with the human immunodeficiency virus (HIV) results in a profound immunosuppression due predominantly to a selective depletion of helper/inducer T lymphocytes that express the receptor for the virus (the CD4 molecule). HIV also has tropism for the brain leading to neuropsychiatric abnormalities. Besides inducing cell death, HIV can interfere with T4 cell function by various mechanisms. The monocyte serves as a reservoir for HIV and is relatively refractory to its cytopathic effects. HIV can exist in a latent or chronic form which can be converted to a productive infection by a variety of inductive signals.
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