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Science 29 January 1988:
Vol. 239. no. 4839, pp. 502 - 504
DOI: 10.1126/science.2829354
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Articles

Science, Vol 239, Issue 4839, 502-504
Copyright © 1988 by American Association for the Advancement of Science

articles

Monocyte-derived human B-cell growth factor identified as interferon-beta 2 (BSF-2, IL-6)

G Tosato, KB Seamon, ND Goldman, PB Sehgal, LT May, GC Washington, KD Jones, and SE Pike

Division of Biochemistry and Biophysics, Food and Drug Administration, Bethesda, MD 20892.

Soluble products of either Epstein-Barr virus (EBV)-infected B cells or activated monocytes promote the proliferation of EBV-infected B cells and permit their growth at low cell densities. This suggests that growth factors are important for B-cell immortalization by EBV. In this study, a monocyte-derived factor that promotes the growth of EBV-infected b cells was purified and identified as interferon-beta 2 (IFN-beta 2), which is also known as 26-kilodalton protein, B-cell differentiation factor (BSF-2), and interleukin-6 (IL-6). The purified protein has a specific activity of approximately 4 X 10(7) units per milligram of protein in assays of B-cell growth. Thus, IFN-beta 2/BSF-2 is a B-cell growth factor that promotes the proliferation of human B cells infected with EBV.


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