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Science 22 January 1988:
Vol. 239. no. 4838, pp. 398 - 401
DOI: 10.1126/science.2447651
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Articles
Science, Vol 239, Issue 4838, 398-401
Copyright © 1988 by American Association for the Advancement of Science
The cellular src gene product regulates junctional cell-to-cell communication
R Azarnia,
S Reddy,
TE Kmiecik,
D Shalloway,
and
WR Loewenstein
Department of Physiology and Biophysics, University of Miami School of Medicine, FL 33136.
Overexpression of the cellular src gene in NIH 3T3 cells causes reduction of cell-to-cell transmission of molecules in the 400- to 700-dalton range. This down-regulation of gap junctional communication correlates with the activity of the gene product, the protein tyrosine kinase pp60c-src. The down-regulation was enhanced by point mutation of Tyr527 (a site that is phosphorylated in pp60c-src and that inhibits kinase activity) or by substitution of the viral-src for the cellular-src carboxyl-terminal coding region. Mutation of Tyr416 (a site phosphorylated upon Tyr527 mutation) suppresses both the down-regulation of communication by Tyr527 mutation and that by gene overexpression. The regulation of communication by src may be important in the control of embryonic development and cellular growth.
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