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Science 15 January 1988:
Vol. 239. no. 4837, pp. 290 - 292
DOI: 10.1126/science.3276004

Articles

Science, Vol 239, Issue 4837, 290-292
Copyright © 1988 by American Association for the Advancement of Science


articles

Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo

WF Hickey and H Kimura

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104-6079.

A crucial question in the study of immunological reactions in the central nervous system (CNS) concerns the identity of the parenchymal cells that function as the antigen-presenting cells in that organ. Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived. In addition, these perivascular cells are fully competent to present antigen to lymphocytes in an appropriately restricted manner. These findings are important for bone marrow transplantation and for neuroimmunological diseases such as multiple sclerosis.


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Characterization of a Novel Bax-Associated Protein Expressed in Hemopoietic Tissues and Regulated During Thymocyte Apoptosis.
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Presentation of Proteolipid Protein Epitopes and B7-1-Dependent Activation of Encephalitogenic T Cells by IFN-{gamma}-Activated SJL/J Astrocytes.
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Stem cells transplantation-a cure for autoimmune diseases.
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C. M. McManus, C. F. Brosnan, and J. W. Berman (1998)
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Critical Points of Tumor Necrosis Factor Action in Central Nervous System Autoimmune Inflammation Defined by Gene Targeting.
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D. W. Kennedy and J. L. Abkowitz (1997)
Blood 90, 986-993
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Neurons Promote Macrophage Proliferation by Producing Transforming Growth Factor-beta 2.
A. Dobbertin, P. Schmid, M. Gelman, J. Glowinski, and M. Mallat (1997)
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Bone Marrow Transplantation in Acid Sphingomyelinase-Deficient Mice: Engraftment and Cell Migration Into the Brain as a Function of Radiation, Age, and Phenotype.
S. R.P. Miranda, S. Erlich, J. W.M. Visser, S. Gatt, A. Dagan, V. L. Friedrich Jr, and E. H. Schuchman (1997)
Blood 90, 444-452
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Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages.
S. Fazio, V. R. Babaev, A. B. Murray, A. H. Hasty, K. J. Carter, L. A. Gleaves, J. B. Atkinson, and M. F. Linton (1997)
PNAS 94, 4647-4652
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Major Histocompatibility Class II Molecules in the CNS: Increased Microglial Expression at the Onset of Narcolepsy in a Canine Model.
M. Tafti, S. Nishino, M. S. Aldrich, W. Liao, W. C. Dement, and E. Mignot (1996)
J. Neurosci. 16, 4588-4595
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Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells..
X Y Zhou, H Morreau, R Rottier, D Davis, E Bonten, N Gillemans, D Wenger, F G Grosveld, P Doherty, and K Suzuki (1995)
Genes & Dev. 9, 2623-2634
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Prevention of atherosclerosis in apolipoprotein E-deficient mice by bone marrow transplantation.
M. Linton, J. Atkinson, and S Fazio (1995)
Science 267, 1034-1037
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Case 40-1993- A 61-Year-Old Woman with Jaundice, Anemia, Thrombocytopenia, and Leukocytosis.
D. W. Golde and D. Rubin (1993)
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