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Science 15 January 1988:
Vol. 239. no. 4837, pp. 278 - 280
DOI: 10.1126/science.2892268
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Articles

Science, Vol 239, Issue 4837, 278-280
Copyright © 1988 by American Association for the Advancement of Science

articles

Somatostatin augments the M-current in hippocampal neurons

SD Moore, SG Madamba, M Joels, and GR Siggins

Research Institute of Scripps Clinic, La Jolla, CA 92037.

Immunocytochemical and electrophysiological evidence suggests that somatostatin may be a transmitter in the hippocampus. To characterize the ionic mechanisms underlying somatostatin effects, voltage-clamp and current-clamp studies on single CA1 pyramidal neurons in the hippocampal slice preparation were performed. Both somatostatin-28 and somatostatin-14 elicited a steady outward current and selectively augmented the noninactivating, voltage-dependent outward potassium current known as the M-current. Since the muscarinic cholinergic agonists carbachol and muscarine antagonized this current, these results suggest a reciprocal regulation of the M-current by somatostatin and acetylcholine.


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